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Abstract

Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.

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/content/10.2807/1560-7917.ES.2025.30.13.2500148
2025-04-03
2025-04-04
/content/10.2807/1560-7917.ES.2025.30.13.2500148
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Fulminant infective endocarditis with toxin-negative Corynebacterium diphtheriae in people with substance use experiencing homelessness, England, 2024 to 2025
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Tara+Patel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Patel Tara</a>, <a href="/search?value1=Tasnim+Anwar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Anwar Tasnim</a>, <a href="/search?value1=Eleni+Mavrogiorgou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mavrogiorgou Eleni</a>, <a href="/search?value1=Natasa+Utjesanovic&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Utjesanovic Natasa</a>, <a href="/search?value1=Anna+Aryee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aryee Anna</a>, <a href="/search?value1=David+J+Litt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Litt David J</a>, <a href="/search?value1=Joshua+C.+D%E2%80%99Aeth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">D’Aeth Joshua C.</a>, <a href="/search?value1=Christopher+Primus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Primus Christopher</a>, <a href="/search?value1=Satya+Das&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Das Satya</a>, <a href="/search?value1=Nikolaos+Karogiannis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Karogiannis Nikolaos</a>, <a href="/search?value1=Karthik+Paranthaman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paranthaman Karthik</a>, <a href="/search?value1=Gayatri+Amirthalingam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amirthalingam Gayatri</a>, <a href="/search?value1=Rebecca+Cordery&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cordery Rebecca</a></span>. Fulminant infective endocarditis with toxin-negative Corynebacterium diphtheriae in people with substance use experiencing homelessness, England, 2024 to 2025. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(13):pii=2500148. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.13.2500148" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.13.2500148</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Feb 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Apr 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.13.2500148
/content/10.2807/1560-7917.ES.2025.30.13.2500148
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