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Abstract

Between 2021 and 2024, we detected carbapenemase gene in 16 of 11,398 (SE) isolates: 10 SE 1,4,[5],12:i:-, three Bovismorbificans, two London and one Rissen from pigs, humans, pork meat and wild roe deer. The gene was first detected in pig isolates, later in humans, suggesting zoonotic transmission. Phylogenetic analysis indicated that horizontal transfer, mainly through plasmids, contributed to the spread. These findings highlight a possible emerging public health threat and the importance of One Health surveillance.

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2025-04-03
2025-04-29
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References

  1. Potron A, Nordmann P, Lafeuille E, Al Maskari Z, Al Rashdi F, Poirel L. Characterization of OXA-181, a carbapenem-hydrolyzing class D beta-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother. 2011;55(10):4896-9.  https://doi.org/10.1128/AAC.00481-11  PMID: 21768505 
  2. Carfora V, Diaconu EL, Ianzano A, Di Matteo P, Amoruso R, Dell’Aira E, et al. The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals. Front Microbiol. 2022;13:1016895.  https://doi.org/10.3389/fmicb.2022.1016895  PMID: 36466661 
  3. European Food Safety Authority (EFSA)European Centre for Disease Prevention and Control (ECDC). Plain Language Summary of the European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2022-2023. EFSA J. 2025;23(3):ep230301. PMID: 40046901 
  4. Istituto Nazionale di Statistica (Istat). Data on livestock. Rome: IStat. [Accessed: 26 Mar 2025]. Available from: http://dati.istat.it/Index.aspx?lang=en&SubSessionId=86044e13-a6d0-4917-8795-c53fcd71a7bf
  5. Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020;75(12):3491-500.  https://doi.org/10.1093/jac/dkaa345  PMID: 32780112 
  6. Camacho C, Coulouris G, Avagyan V, Ma N, Papadopoulos J, Bealer K, et al. BLAST+: architecture and applications. BMC Bioinformatics. 2009;10(1):421.  https://doi.org/10.1186/1471-2105-10-421  PMID: 20003500 
  7. European Commission (EC). Commission Implementing Decision (EU) 2020/1729 of 17 November 2020 on the monitoring and reporting of antimicrobial resistance in zoonotic and commensal bacteria and repealing Implementing Decision 2013/652/EU. Brussels: EC; 17 Nov 2020. Available from: http://data.europa.eu/eli/dec_impl/2020/1729/oj
  8. European Food Safety Authority (EFSA)Amore G, Beloeil P-A, Fierro RG, Guerra B, Rizzi V, et al. Manual for reporting 2023 antimicrobial resistance data under Directive 2003/99/EC and Commission Implementing Decision (EU) 2020/1729. EFSA Support Publ. 2024;21(1):8585.  https://doi.org/10.2903/sp.efsa.2024.EN-8585 
  9. The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 11.0, Jan 2023. Available from: https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Disk_test_documents/2023_manuals/Manual_v_11.0_EUCAST_Disk_Test_2023.pdf
  10. Wick RR, Judd LM, Gorrie CL, Holt KE. Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. PLoS Comput Biol. 2017;13(6):e1005595.  https://doi.org/10.1371/journal.pcbi.1005595  PMID: 28594827 
  11. Davis S, Petengill JB, Luo Y, Payne J, Shpuntoff A, Rand H, et al. CFSAN SNP Pipeline: an automated method for constructing SNP matrices from next generation sequence data. PeerJ Comput Sci. 2015;1:e20.  https://doi.org/10.7717/peerj-cs.20 
  12. Møller TSB, Liu G, Boysen A, Thomsen LE, Lüthje FL, Mortensen S, et al. Treatment with cefotaxime affects expression of conjugation associated proteins and conjugation transfer frequency of an IncI1 plasmid in Escherichia coli. Front Microbiol. 2017;8:2365.  https://doi.org/10.3389/fmicb.2017.02365  PMID: 29238335 
  13. Threlfall EJ. Antimicrobial drug resistance in Salmonella: problems and perspectives in food- and water-borne infections. FEMS Microbiol Rev. 2002;26(2):141-8.  https://doi.org/10.1111/j.1574-6976.2002.tb00606.x  PMID: 12069879 
Emergence of Salmonella enterica carrying blaOXA-181 carbapenemase gene, Italy, 2021 to 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Luca+Bolzoni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bolzoni Luca</a>, <a href="/search?value1=Erika+Scaltriti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scaltriti Erika</a>, <a href="/search?value1=Chiara+Bracchi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bracchi Chiara</a>, <a href="/search?value1=Sara+Angelone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Angelone Sara</a>, <a href="/search?value1=Ilaria+Menozzi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Menozzi Ilaria</a>, <a href="/search?value1=Roberta+Taddei&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Taddei Roberta</a>, <a href="/search?value1=Patricia+Alba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alba Patricia</a>, <a href="/search?value1=Virginia+Carfora&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carfora Virginia</a>, <a href="/search?value1=Elena+Lavinia+Diaconu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Diaconu Elena Lavinia</a>, <a href="/search?value1=Marina+Morganti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morganti Marina</a>, <a href="/search?value1=Alessandra+Dodi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dodi Alessandra</a>, <a href="/search?value1=Melissa+Berni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berni Melissa</a>, <a href="/search?value1=Laura+Manni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Manni Laura</a>, <a href="/search?value1=Massimiliano+Vinci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vinci Massimiliano</a>, <a href="/search?value1=Martina+Tambassi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tambassi Martina</a>, <a href="/search?value1=Laura+Mazzera&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazzera Laura</a>, <a href="/search?value1=Irene+Venturelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Venturelli Irene</a>, <a href="/search?value1=Simone+Ambretti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ambretti Simone</a>, <a href="/search?value1=Antonio+Battisti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Battisti Antonio</a>, <a href="/search?value1=Stefano+Pongolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pongolini Stefano</a></span>. Emergence of Salmonella enterica carrying blaOXA-181 carbapenemase gene, Italy, 2021 to 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(13):pii=2500175. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.13.2500175" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.13.2500175</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Mar 2025;&nbsp;&nbsp; <span class="generated">Accepted</span>: 02 Apr 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.13.2500175
/content/10.2807/1560-7917.ES.2025.30.13.2500175
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