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Abstract

A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were detected outside Wuhan in the early outbreak phase, we estimate the mean incubation period to be 6.4 days (95% credible interval: 5.6–7.7), ranging from 2.1 to 11.1 days (2.5th to 97.5th percentile). These values should help inform 2019-nCoV case definitions and appropriate quarantine durations.

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/content/10.2807/1560-7917.ES.2020.25.5.2000062
2020-02-06
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.5.2000062
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References

  1. World Health Organization (WHO). WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China. Beijing: WHO; 9 Jan 2020. [Accessed 26 Jan 2020]. https://www.who.int/china/news/detail/09-01-2020-who-statement-regarding-cluster-of-pneumonia-cases-in-wuhan-china
  2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 24 Jan 2020:NEJMoa2001017.  https://doi.org/10.1056/NEJMoa2001017  PMID: 31978945 
  3. Imai N, Dorigatti I, Cori A, Donnelly C, Riley S, Ferguson NM. Report 2: Estimating the potential total number of novel Coronavirus cases in Wuhan City, China. London; 2020. Available from: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/2019-nCoV-outbreak-report-22-01-2020.pdf
  4. Leung K, Wu JT, Leung GM. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet. 31 Jan 2020. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30260-9/fulltext
  5. Nishiura H, Jung SM, Linton NM, Kinoshita R, Yang Y, Hayashi K, et al. The Extent of Transmission of Novel Coronavirus in Wuhan, China, 2020. J Clin Med. 2020;9(2):330.  https://doi.org/10.3390/jcm9020330  PMID: 31991628 
  6. Imai N, Cori A, Dorigatti I, Baguelin M, Donnelly CA, Riley S, et al. Report 3: Transmissibility of 2019-nCoV. London; 2020. Available from: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf
  7. Zhao S, Lin Q, Ran J, Musa SS, Yang G, Wang W, et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int J Infect Dis. 30 Jan 2020. Available from: https://www.sciencedirect.com/science/article/pii/S1201971220300539
  8. Online repository. Boston: Laboratory for the Modeling of Biological and Socio-technical Systems (MOBS). [Accessed 29 Jan 2020]. Available from: https://docs.google.com/spreadsheets/d/1jS24DjSPVWa4iuxuD4OAXrE3QeI8c9BC1hSlqr-NMiU/edit#gid=1449891965
  9. Stan Development Team. RStan: the R interface to Stan. R package version 2.18.2. 2018. Available from: https://cran.r-project.org/web/packages/rstan/vignettes/rstan.html
  10. Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;24:S0140-6736(20)30154-9.  https://doi.org/10.1016/S0140-6736(20)30154-9  PMID: 31986261 
  11. European Centre for Disease Prevention and Control (ECDC). Q & A on novel coronavirus. Stockholm: ECDC; 2020. [Accessed 4 Feb 2020]. Available from: https://www.ecdc.europa.eu/en/novel-coronavirus-china/questions-answers
  12. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;29:NEJMoa2001316.  https://doi.org/10.1056/NEJMoa2001316  PMID: 31995857 
  13. Liu T, Hu J, Kang M, Lin L, Zhong H, Xiao J, et al. Transmission dynamics of 2019 novel coronavirus (2019-nCoV). bioRxiv. 2020;919787: (Preprint). Available from: http://dx.doi.org/10.1101/2020.01.25.919787
  14. Donnelly CA, Ghani AC, Leung GM, Hedley AJ, Fraser C, Riley S, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet. 2003;361(9371):1761-6.  https://doi.org/10.1016/S0140-6736(03)13410-1  PMID: 12781533 
  15. Department of Error. Erratum to Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet. 2004;364(9429). Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)16624-5/fulltext
  16. Cowling BJ, Muller MP, Wong IO, Ho LM, Louie M, McGeer A, et al. Alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. Epidemiology. 2007;18(2):253-9.  https://doi.org/10.1097/01.ede.0000254660.07942.fb  PMID: 17235210 
  17. Lau EH, Hsiung CA, Cowling BJ, Chen CH, Ho LM, Tsang T, et al. A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan. BMC Infect Dis. 2010;10(1):50.  https://doi.org/10.1186/1471-2334-10-50  PMID: 20205928 
  18. Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis. 2009;9(5):291-300.  https://doi.org/10.1016/S1473-3099(09)70069-6  PMID: 19393959 
  19. Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, et al. KSA MERS-CoV Investigation Team. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369(5):407-16.  https://doi.org/10.1056/NEJMoa1306742  PMID: 23782161 
  20. Cauchemez S, Fraser C, Van Kerkhove MD, Donnelly CA, Riley S, Rambaut A, et al. Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect Dis. 2014;14(1):50-6.  https://doi.org/10.1016/S1473-3099(13)70304-9  PMID: 24239323 
  21. Virlogeux V, Fang VJ, Park M, Wu JT, Cowling BJ. Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia. Sci Rep. 2016;6(1):35839.  https://doi.org/10.1038/srep35839  PMID: 27775012 
Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jantien+A+Backer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Backer Jantien A</a>, <a href="/search?value1=Don+Klinkenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klinkenberg Don</a>, <a href="/search?value1=Jacco+Wallinga&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wallinga Jacco</a></span>. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(5):pii=2000062. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.5.2000062" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.5.2000062</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Jan 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Feb 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.5.2000062
/content/10.2807/1560-7917.ES.2020.25.5.2000062
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