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SDG 3: Tuberculosis

Abstract

This report documents the case of a Ukrainian patient infected with an extensively drug-resistant (XDR) lineage 2 strain harbouring the rifampicin resistance mutation RpoB I491F. This mutation is not detected by routine molecular WHO-recommended rapid diagnostics, complicating the detection and treatment of these strains. The occurrence of such mutations underscores the need for enhanced diagnostic techniques and tailored treatment regimens, especially in eastern Europe where lineage 2 strains and XDR-tuberculosis are prevalent.

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/content/10.2807/1560-7917.ES.2024.29.28.2400420
2024-07-11
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.28.2400420
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References

  1. World Health Orgznization (WHO). Global tuberculosis report 2023. Geneva: WHO; 2023. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023
  2. World Health Organization (WHO). WHO operational handbook on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection: web annex B: critical concentrations for pretomanid and cycloserine: WHO policy statement. 3rd ed. Geneva: WHO; 2024. Available from: https://iris.who.int/handle/10665/376285
  3. Dooley KE, Hendricks B, Gupte N, Barnes G, Narunsky K, Whitelaw C, et al. Assessing pretomanid for tuberculosis (APT), a randomized phase 2 trial of pretomanid-containing regimens for drug-sensitive tuberculosis: 12-week results. Am J Respir Crit Care Med. 2023;207(7):929-35.  https://doi.org/10.1164/rccm.202208-1475OC  PMID: 36455068 
  4. Ignatius EH, Abdelwahab MT, Hendricks B, Gupte N, Narunsky K, Wiesner L, et al. Pretomanid pharmacokinetics in the presence of rifamycins: interim results from a randomized trial among patients with tuberculosis. Antimicrob Agents Chemother. 2021;65(2):e01196-20.  https://doi.org/10.1128/AAC.01196-20  PMID: 33229425 
  5. Modongo C, Barilar I, Wang Q, Molefi T, Makhondo T, Niemann S, et al. Tuberculosis variant with rifampin resistance undetectable by Xpert MTB/RIF, Botswana. Emerg Infect Dis. 2023;29(11):2403-6.  https://doi.org/10.3201/eid2911.230987  PMID: 37877680 
  6. Sanchez-Padilla E, Merker M, Beckert P, Jochims F, Dlamini T, Kahn P, et al. Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland. N Engl J Med. 2015;372(12):1181-2.  https://doi.org/10.1056/NEJMc1413930  PMID: 25785984 
  7. Makhado NA, Matabane E, Faccin M, Pinçon C, Jouet A, Boutachkourt F, et al. Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study. Lancet Infect Dis. 2018;18(12):1350-9.  https://doi.org/10.1016/S1473-3099(18)30496-1  PMID: 30342828 
  8. Mon AS, Ei PW, Htwe MM, Nyunt MH, Win SM, Nyunt WW, et al. First detection of Mycobacterium tuberculosis clinical isolates harboring i491f borderline resistance rpob mutation in Myanmar. Antimicrob Agents Chemother. 2022;66(12):e0092522.  https://doi.org/10.1128/aac.00925-22  PMID: 36342155 
  9. Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, José B, et al. Emergence of bedaquiline-resistant tuberculosis and of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains with rpoB Ile491Phe mutation not detected by Xpert MTB/RIF in Mozambique: a retrospective observational study. Lancet Infect Dis. 2024;24(3):297-307.  https://doi.org/10.1016/S1473-3099(23)00498-X  PMID: 37956677 
  10. Beckert P, Sanchez-Padilla E, Merker M, Dreyer V, Kohl TA, Utpatel C, et al. MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era. Genome Med. 2020;12(1):104.  https://doi.org/10.1186/s13073-020-00793-8  PMID: 33239092 
  11. Köser CU, Georghiou SB, Schön T, Salfinger M. On the consequences of poorly defined breakpoints for rifampin susceptibility testing of Mycobacterium tuberculosis complex. J Clin Microbiol. 2021;59(4):e02328-20.  https://doi.org/10.1128/JCM.02328-20  PMID: 33568463 
  12. Sonnenkalb L, Carter JJ, Spitaleri A, Iqbal Z, Hunt M, Malone KM, et al. Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis. Lancet Microbe. 2023;4(5):e358-68.  https://doi.org/10.1016/S2666-5247(23)00002-2  PMID: 37003285 
  13. World Health Organization (WHO), European Centre for Disease Prevention and Control (ECDC). Tuberculosis surveillance and monitoring in Europe 2024 – 2022 data. Geneva: WHO, Stockholm: ECDC; 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/tuberculosis-surveillance-and-monitoring-europe-2024-2022-data
First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Inna+Friesen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Friesen Inna</a>, <a href="/search?value1=Viola+Dreyer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dreyer Viola</a>, <a href="/search?value1=Angela+Klingm%C3%BCller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klingmüller Angela</a>, <a href="/search?value1=Sylvia+Zuber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zuber Sylvia</a>, <a href="/search?value1=Ada+M+Hoffmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoffmann Ada M</a>, <a href="/search?value1=Isabelle+Su%C3%A1rez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Suárez Isabelle</a>, <a href="/search?value1=Beatrice+Sch%C3%BCtz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schütz Beatrice</a>, <a href="/search?value1=Tim+Pre%C3%9Fel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Preßel Tim</a>, <a href="/search?value1=S%C3%B6nke+Andres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andres Sönke</a>, <a href="/search?value1=Stefan+Niemann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Niemann Stefan</a>, <a href="/search?value1=Jan+Rybniker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rybniker Jan</a></span>. First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(28):pii=2400420. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.28.2400420" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.28.2400420</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Jun 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Jul 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.28.2400420
/content/10.2807/1560-7917.ES.2024.29.28.2400420
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