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Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23
- Danuta M Skowronski1,2 , Erica SY Chuang1 , Suzana Sabaiduc1 , Samantha E Kaweski1 , Shinhye Kim1 , James A Dickinson3 , Romy Olsha4 , Jonathan B Gubbay4,5 , Nathan Zelyas6 , Hugues Charest7 , Nathalie Bastien8 , Agatha N Jassem1,2 , Gaston De Serres7,9,10
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View Affiliations Hide AffiliationsAffiliations: 1 British Columbia Centre for Disease Control, Vancouver, Canada 2 University of British Columbia, Vancouver, Canada 3 University of Calgary, Calgary, Canada 4 Public Health Ontario, Toronto, Canada 5 University of Toronto, Toronto, Canada 6 Public Health Laboratory, Alberta Precision Laboratories, Edmonton, Canada 7 Institut National de Santé Publique du Québec, Québec, Canada 8 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada 9 Laval University, Quebec, Canada 10 Centre Hospitalier Universitaire de Québec, Québec, CanadaDanuta M SkowronskiDanuta.skowronski bccdc.ca
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Citation style for this article: Skowronski Danuta M, Chuang Erica SY, Sabaiduc Suzana, Kaweski Samantha E, Kim Shinhye, Dickinson James A, Olsha Romy, Gubbay Jonathan B, Zelyas Nathan, Charest Hugues, Bastien Nathalie, Jassem Agatha N, De Serres Gaston. Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23. Euro Surveill. 2023;28(5):pii=2300043. https://doi.org/10.2807/1560-7917.ES.2023.28.5.2300043 Received: 23 Jan 2023; Accepted: 02 Feb 2023
Abstract
The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, and reassortment such that H156 viruses acquired neuraminidase from clade 3C.2a1b.1a. Vaccine provided substantial protection with A(H3N2) VE of 54% (95% CI: 38 to 66) overall. VE was similar against H156 and vaccine-like S156 viruses, but with potential variation based on diversity at position 135.
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References
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Kim S, Chuang ESY, Sabaiduc S, Olsha R, Kaweski SE, Zelyas N, et al. Influenza vaccine effectiveness against A(H3N2) during the delayed 2021/22 epidemic in Canada. Euro Surveill. 2022;27(38):2200720. https://doi.org/10.2807/1560-7917.ES.2022.27.38.2200720 PMID: 36148674
-
Buckrell S, Ben Moussa M, Bui T, Rahal A, Schmidt K, Lee L, et al. National influenza annual report, Canada, 2021-2022: A brief, late influenza epidemic. Can Commun Dis Rep. 2022;48(10):473-83. https://doi.org/10.14745/ccdr.v48i10a07
-
Public Health Agency of Canada (PHAC). FluWatch report: January 8 to January 14, 2023 (week 2). Ottawa: PHAC; 2023. [Accessed: 31 Jan 2023). Available from: https://www.canada.ca/en/public-health/services/diseases/flu-influenza/influenza-surveillance/weekly-reports-2022-2023-season.html
-
Ben Moussa M, Buckrell S, Rahal A, Schmidt K, Lee L, Bastien N, et al. National influenza mid-season report, 2022-2023: A rapid and early epidemic onset. Can Commun Dis Rep. 2023;49(1):10-4. https://doi.org/10.14745/ccdr.v49i01a03
-
European Centre for Disease Prevention and Control (ECDC). Flu New Europe: Joint ECDC-WHO/Europe weekly influenza update. Week 02/2023 (9 January – 15 January 2023). [Accessed: 31 Jan 2023]. Stockholm: ECDC; 2022. Available from: http://flunewseurope.org
-
Centers for Disease Control and Prevention (CDC). FluView: Past weekly surveillance reports. 2022-2023, January 14, 2023—Week 2. Atlanta: CDC; 2022. [Accessed: 31 Jan 2023]. Available from: https://www.cdc.gov/flu/weekly/pastreports.htm
-
Skowronski DM, Leir S, Sabaiduc S, Chambers C, Zou M, Rose C, et al. Influenza vaccine effectiveness by A(H3N2) phylogenetic subcluster and prior vaccination history: 2016-2017 and 2017-2018 epidemics in Canada. J Infect Dis. 2022;225(8):1387-98. https://doi.org/10.1093/infdis/jiaa138 PMID: 32215564
-
Canadian Sentinel Practitioner Surveillance Network. Canadian Sentinel Practitioner Surveillance Network (SPSN) influenza vaccine effectiveness estimates % (95% CI), 2004-05 to 2021-22 seasons. [Accessed: 16 Jan 2023]. Available from: http://www.bccdc.ca/resource-gallery/Documents/Statistics%20and%20Research/Publications/Epid/Influenza%20and%20Respiratory/SPSN_VE_By_Year_Table.pdf
-
National Advisory Committee on Immunization. Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2022-2023. Ottawa (ON): Public Health Agency of Canada; 2022. [Accessed: 22 Jan 2023]. Available from: https://www.canada.ca/en/public-health/services/publications/vaccines-immunization/canadian-immunization-guide-statement-seasonal-influenza-vaccine-2022-2023.html
-
World Health Organization (WHO). Recommended composition of influenza virus vaccines for use in the 2022-2023 northern hemisphere influenza season. Geneva: WHO; 2022. Available from: https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2022-2023-northern-hemisphere-influenza-season
-
Francis Crick Institute. Worldwide influenza centre. Annual and interim reports. February 2022 and September 2022 interim reports. London: Francis Crick Institute. [Accessed: 16 Jan 2023]. Available from: https://www.crick.ac.uk/research/platforms-and-facilities/worldwide-influenza-centre/annual-and-interim-reports
-
European Centre for Disease Prevention and Control (ECDC). Influenza virus characterization, summary Europe, November 2022. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/influenza-virus-characterization-summary-europe-november-2022
-
Koel BF, Burke DF, Bestebroer TM, van der Vliet S, Zondag GC, Vervaet G, et al. Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. Science. 2013;342(6161):976-9. https://doi.org/10.1126/science.1244730 PMID: 24264991
-
Lee J, Neher R, Bedford T. Real-time tracking of influenza A/H3N2 evolution. Nextstrain. [Accessed: 30 Jan 2023]. Available from: https://nextstrain.org/flu/seasonal/h3n2/ha/2y
-
Zhou B, Donnelly ME, Scholes DT, St George K, Hatta M, Kawaoka Y, et al. Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol. 2009;83(19):10309-13. https://doi.org/10.1128/JVI.01109-09 PMID: 19605485
-
Hickman R, Nguyen J, Lee TD, Tyson JR, Azana R, Tsang F, et al. Rapid, high-throughput, cost effective whole genome sequencing of SARS-CoV-2 using a condensed one hour library preparation of the Illumina DNA Prep kit. medRxiv. 2022.02.07.22269672. Pre-print. [Accessed: 26 Jan 2023] https://doi.org/10.1101/2022.02.07.22269672 . https://doi.org/10.1101/2022.02.07.22269672
-
Illumina. Sequencing the rapidly evolving influenza A virus on the MiSeq system. San Diego: Illumina; 2017. Available from: https://www.illumina.com/content/dam/illumina-marketing/documents/products/appnotes/miseq-nextera-xt-influenza-application-note-770-2015-053.pdf
-
Kuchinski K. FluViewer [Source code]. 2022 Mar 17 [Accessed: 26 Jan 2023]. GitHub. Available from: https://github.com/KevinKuchinski/FluViewer
-
Eisler D, Fornika D, Tindale LC, Chan T, Sabaiduc S, Hickman R, et al. Influenza Classification Suite: An automated Galaxy workflow for rapid influenza sequence analysis. Influenza Other Respir Viruses. 2020;14(3):358-62. https://doi.org/10.1111/irv.12722 PMID: 32064792
-
Ndifon W, Wingreen NS, Levin SA. Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines. Proc Natl Acad Sci USA. 2009;106(21):8701-6. https://doi.org/10.1073/pnas.0903427106 PMID: 19439657
-
Shu Y, McCauley J. GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill. 2017;22(13):30494. https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494 PMID: 28382917
-
Skowronski DM, Sabaiduc S, Leir S, Rose C, Zou M, Murti M, et al. Paradoxical clade- and age-specific vaccine effectiveness during the 2018/19 influenza A(H3N2) epidemic in Canada: potential imprint-regulated effect of vaccine (I-REV). Euro Surveill. 2019;24(46):1900585. https://doi.org/10.2807/1560-7917.ES.2019.24.46.1900585 PMID: 31771709
-
Firth D. Bias reduction of maximum likelihood estimates. Biometrika. 1993;80(1):27-38. https://doi.org/10.1093/biomet/80.1.27
-
Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002;21(16):2409-19. https://doi.org/10.1002/sim.1047 PMID: 12210625
-
Doll MK, Pettigrew SM, Ma J, Verma A. Effects of confounding bias in coronavirus disease 2019 (COVID-19) and influenza vaccine effectiveness test-negative designs due to correlated influenza and COVID-19 vaccination behaviors. Clin Infect Dis. 2022;75(1):e564-71. https://doi.org/10.1093/cid/ciac234 PMID: 35325923
-
Kissling E, Pozo F, Martínez-Baz I, Buda S, Vilcu A-M, Domegan L, et al. Influenza vaccine effectiveness against influenza A subtypes in Europe: Results from the 2021-2022 I-MOVE primary care multicentre study. Influenza Other Respir Viruses. 2023;17(1):e13069. https://doi.org/10.1111/irv.13069 PMID: 36702797
-
Price AM, Flannery B, Talbot HK, Grijalva CG, Wernli KJ, Phillips CH, et al. Influenza vaccine effectiveness against influenza A(H3N2)-related illness in the United States during the 2021-2022 influenza season. Clin Infect Dis. 2022;ciac941. https://doi.org/10.1093/cid/ciac941 PMID: 36504336
-
Kissling E, Pozo F, Buda S, Vilcu A-M, Gherasim A, Brytting M, et al. Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort. Euro Surveill. 2019;24(48):1900604. https://doi.org/10.2807/1560-7917.ES.2019.24.48.1900604 PMID: 31796152
-
Francis ME, King ML, Kelvin AA. Back to the future for influenza preimmunity-looking back at influenza virus history to infer the outcome of future infections. Viruses. 2019;11(2):E122. https://doi.org/10.3390/v11020122 PMID: 30704019
-
Griggs EP, Flannery B, Foppa IM, Gaglani M, Murthy K, Jackson ML, et al. Role of age in the spread of influenza, 2011-2019: Data from the US influenza vaccine effectiveness network. Am J Epidemiol. 2022;191(3):465-71. https://doi.org/10.1093/aje/kwab205 PMID: 34274963
-
Schanzer D, Vachon J, Pelletier L. Age-specific differences in influenza A epidemic curves: do children drive the spread of influenza epidemics? Am J Epidemiol. 2011;174(1):109-17. https://doi.org/10.1093/aje/kwr037 PMID: 21602300
-
Potter BI, Kondor R, Hadfield J, Huddleston J, Barnes J, Rowe T, et al. Evolution and rapid spread of a reassortant A(H3N2) virus that predominated the 2017-2018 influenza season. Virus Evol. 2019;5(2):vez046. https://doi.org/10.1093/ve/vez046 PMID: 33282337
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