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Abstract

Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of , , and genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study.

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/content/10.2807/1560-7917.ES.2021.26.39.2100902
2021-09-30
2024-12-23
/content/10.2807/1560-7917.ES.2021.26.39.2100902
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Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Natalia+Mazur-Panasiuk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazur-Panasiuk Natalia</a>, <a href="/search?value1=Lukasz+Rabalski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rabalski Lukasz</a>, <a href="/search?value1=Tomasz+Gromowski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gromowski Tomasz</a>, <a href="/search?value1=Grzegorz+Nowicki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nowicki Grzegorz</a>, <a href="/search?value1=Michal+Kowalski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kowalski Michal</a>, <a href="/search?value1=Witold+Wydmanski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wydmanski Witold</a>, <a href="/search?value1=Piotr+Szulc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Szulc Piotr</a>, <a href="/search?value1=Maciej+Kosinski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kosinski Maciej</a>, <a href="/search?value1=Karolina+Gackowska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gackowska Karolina</a>, <a href="/search?value1=Natalia+Drweska-Matelska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drweska-Matelska Natalia</a>, <a href="/search?value1=Jakub+Grabowski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grabowski Jakub</a>, <a href="/search?value1=Anna+Piotrowska-Mietelska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piotrowska-Mietelska Anna</a>, <a href="/search?value1=Boguslaw+Szewczyk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Szewczyk Boguslaw</a>, <a href="/search?value1=Krystyna+Bienkowska-Szewczyk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bienkowska-Szewczyk Krystyna</a>, <a href="/search?value1=Jakub+Swadzba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Swadzba Jakub</a>, <a href="/search?value1=Pawel+Labaj&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Labaj Pawel</a>, <a href="/search?value1=Maciej+Grzybek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grzybek Maciej</a>, <a href="/search?value1=Krzysztof+Pyrc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pyrc Krzysztof</a></span>. Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(39):pii=2100902. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.39.2100902" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.39.2100902</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Sept 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 Sept 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.39.2100902
/content/10.2807/1560-7917.ES.2021.26.39.2100902
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