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Abstract

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.

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/content/10.2807/1560-7917.ES.2020.25.25.2001122
2020-06-25
2024-11-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.25.2001122
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SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ian+G+Barr&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barr Ian G</a>, <a href="/search?value1=Cleve+Rynehart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rynehart Cleve</a>, <a href="/search?value1=Paul+Whitney&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Whitney Paul</a>, <a href="/search?value1=Julian+Druce&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Druce Julian</a></span>. SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(25):pii=2001122. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.25.2001122" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.25.2001122</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Jun 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Jun 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.25.2001122
/content/10.2807/1560-7917.ES.2020.25.25.2001122
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