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Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20
- Sofie Elisabeth Midgley1 , Kimberley Benschop2 , Robert Dyrdak3,4 , Audrey Mirand5,6 , Jean-Luc Bailly6 , Sibylle Bierbaum7 , Stefan Buderus8 , Sindy Böttcher9 , Anna-Maria Eis-Hübinger10 , Mario Hönemann11 , Veronika Vorobieva Jensen1 , Ulla Birgitte Hartling12 , Cécile Henquell5 , Marcus Panning7 , Marianne Kragh Thomsen13 , Emma B Hodcroft14,15 , Adam Meijer2
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View Affiliations Hide AffiliationsAffiliations: 1 Department for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark 2 Centre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands 3 Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden 4 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden 5 CHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France 6 Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France 7 Institute of Virology, University of Freiburg, Freiburg, Germany 8 Department of General Pediatrics, St.-Marien-Hospital, Bonn, Germany 9 National Reference Center for Poliomyelitis and Enteroviruses, Robert Koch-Institute, Berlin, Germany 10 Institute of Virology, University of Bonn Medical Center, Bonn, Germany 11 Institute of Virology, University of Leipzig, Leipzig, Germany 12 Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark 13 Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark 14 Biozentrum, University of Basel, Basel, Switzerland 15 Swiss Institute of Bioinformatics, Basel, SwitzerlandSofie Elisabeth Midgleysoi ssi.dk
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Citation style for this article: Midgley Sofie Elisabeth, Benschop Kimberley, Dyrdak Robert, Mirand Audrey, Bailly Jean-Luc, Bierbaum Sibylle, Buderus Stefan, Böttcher Sindy, Eis-Hübinger Anna-Maria, Hönemann Mario, Jensen Veronika Vorobieva, Hartling Ulla Birgitte, Henquell Cécile, Panning Marcus, Thomsen Marianne Kragh, Hodcroft Emma B, Meijer Adam. Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20. Euro Surveill. 2020;25(2):pii=1900749. https://doi.org/10.2807/1560-7917.ES.2020.25.2.1900749 Received: 07 Jan 2020; Accepted: 16 Jan 2002
Abstract
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.
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