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Abstract

Two ceftazidime-avibactam (CAZ-AVI)-resistant carbapenemase (KPC)-positive strains, including one pandrug resistant, were isolated in 2019 from two Greek hospitals. The strains were sequence types (ST)s 258 and 147 and both harboured similar self-transmissible IncA/C2 plasmids encoding a novel Lys234Arg variant of the Vietnamese extended-spectrum β-lactamase (VEB)-1, not inhibited by AVI (VEB-25). Conjugal transfer of VEB-25-encoding plasmids to yielded CAZ-AVI-resistant clones, supporting that VEB-25 is directly linked to the derived phenotype.

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/content/10.2807/1560-7917.ES.2020.25.2.1900766
2020-01-16
2024-11-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.2.1900766
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Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB β-lactamase variant with a Lys234Arg substitution, Greece, 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=E.+Voulgari&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Voulgari E.</a>, <a href="/search?value1=S.D.+Kotsakis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kotsakis S.D.</a>, <a href="/search?value1=P.+Giannopoulou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giannopoulou P.</a>, <a href="/search?value1=E.+Perivolioti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Perivolioti E.</a>, <a href="/search?value1=L.S.+Tzouvelekis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tzouvelekis L.S.</a>, <a href="/search?value1=V.+Miriagou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miriagou V.</a></span>. Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB β-lactamase variant with a Lys234Arg substitution, Greece, 2019. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(2):pii=1900766. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.2.1900766" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.2.1900766</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Dec 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 16 Jan 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.2.1900766
/content/10.2807/1560-7917.ES.2020.25.2.1900766
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