1887
Rapid communication Open Access
Like 0

Abstract

The ongoing Ebola outbreak in the eastern Democratic Republic of the Congo is facing unprecedented levels of insecurity and violence. We evaluate the likely impact in terms of added transmissibility and cases of major security incidents in the Butembo coordination hub. We also show that despite this additional burden, an adapted response strategy involving enlarged ring vaccination around clusters of cases and enhanced community engagement managed to bring this main hotspot under control.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.2.1900735
2020-01-16
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.2.1900735
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/2/eurosurv-25-2-3.html?itemId=/content/10.2807/1560-7917.ES.2020.25.2.1900735&mimeType=html&fmt=ahah

References

  1. Aylward B, Barboza P, Bawo L, Bertherat E, Bilivogui P, Blake I, et al. Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections. N Engl J Med. 2014;371(16):1481-95.  https://doi.org/10.1056/NEJMoa1411100  PMID: 25244186 
  2. Agua-Agum J, Ariyarajah A, Aylward B, Bawo L, Bilivogui P, Blake IM, et al. Exposure patterns driving Ebola transmission in West Africa: a retrospective observational study. PLoS Med. 2016;13(11):e1002170.  https://doi.org/10.1371/journal.pmed.1002170  PMID: 27846234 
  3. Agua-Agum J, Ariyarajah A, Aylward B, Blake IM, Brennan R, Cori A, et al. West African Ebola epidemic after one year--slowing but not yet under control. N Engl J Med. 2015;372(6):584-7.  https://doi.org/10.1056/NEJMc1414992  PMID: 25539446 
  4. Heymann DL, Chen L, Takemi K, Fidler DP, Tappero JW, Thomas MJ, et al. Global health security: the wider lessons from the west African Ebola virus disease epidemic. Lancet. 2015;385(9980):1884-901.  https://doi.org/10.1016/S0140-6736(15)60858-3  PMID: 25987157 
  5. Coltart CEM, Lindsey B, Ghinai I, Johnson AM, Heymann DL. The Ebola outbreak, 2013-2016: old lessons for new epidemics. Philos Trans R Soc Lond B Biol Sci. 2017;372(1721):20160297.  https://doi.org/10.1098/rstb.2016.0297  PMID: 28396469 
  6. Moon S, Sridhar D, Pate MA, Jha AK, Clinton C, Delaunay S, et al. Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola. Lancet. 2015;386(10009):2204-21.  https://doi.org/10.1016/S0140-6736(15)00946-0  PMID: 26615326 
  7. Barry A, Ahuka-Mundeke S, Ali Ahmed Y, Allarangar Y, Anoko J, Archer BN, et al. Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April-May, 2018: an epidemiological study. Lancet. 2018;392(10143):213-21.  https://doi.org/10.1016/S0140-6736(18)31387-4  PMID: 30047375 
  8. Ilunga Kalenga O, Moeti M, Sparrow A, Nguyen VK, Lucey D, Ghebreyesus TA. The ongoing Ebola epidemic in the Democratic Republic of Congo, 2018-2019. N Engl J Med. 2019;381(4):373-83.  https://doi.org/10.1056/NEJMsr1904253  PMID: 31141654 
  9. Regules JA, Beigel JH, Paolino KM, Voell J, Castellano AR, Hu Z, et al. A recombinant vesicular stomatitis virus Ebola vaccine. N Engl J Med. 2017;376(4):330-41.  https://doi.org/10.1056/NEJMoa1414216  PMID: 25830322 
  10. World Health Organization (WHO). Surveillance System of Attacks on Healthcare (SSA). Geneva: WHO; 2019. Available from: https://www.who.int/emergencies/attacks-on-health-care/surveillance-system/en/
  11. World Health Organization (WHO). Dead and injured following attacks on Ebola responders in the Democratic Republic of the Congo. Geneva: WHO; 2019. Available from: https://www.who.int/news-room/detail/28-11-2019-dead-and-injured-following-attacks-on-ebola-responders-in-the-democratic-republic-of-the-congo
  12. Wannier SR, Worden L, Hoff NA, Amezcua E, Selo B, Sinai C, et al. Estimating the impact of violent events on transmission in Ebola virus disease outbreak, Democratic Republic of the Congo, 2018-2019. Epidemics. 2019;28:100353.  https://doi.org/10.1016/j.epidem.2019.100353  PMID: 31378584 
  13. Wells CR, Pandey A, Ndeffo Mbah ML, Gaüzère BA, Malvy D, Singer BH, et al. The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the Congo. Proc Natl Acad Sci USA. 2019;116(48):24366-72.  https://doi.org/10.1073/pnas.1913980116  PMID: 31636188 
  14. Kamvar ZN, Cai J, Pulliam JRC, Schumacher J, Jombart T. Epidemic curves made easy using the R package incidence. F1000 Res. 2019;8:139.  https://doi.org/10.12688/f1000research.18002.1  PMID: 31119031 
  15. Wallinga J, Lipsitch M. How generation intervals shape the relationship between growth rates and reproductive numbers. Proc Biol Sci. 2007;274(1609):599-604.  https://doi.org/10.1098/rspb.2006.3754  PMID: 17476782 
/content/10.2807/1560-7917.ES.2020.25.2.1900735
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error