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Abstract

We report two cases of multidrug-resistant urogenital infection with ceftriaxone resistance in a heterosexual couple in south-western France who were successfully treated with a single, high dose of intramuscular ceftriaxone (1 g). Whole genome sequencing of isolate F91 identified MLST13871, NG-MAST1086, NG-STAR233. Patient history revealed the isolate F91 was most likely acquired during a trip to Cambodia and belongs to the successful multidrug-resistant FC428 Asian clone.

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/content/10.2807/1560-7917.ES.2019.24.36.1900528
2019-09-05
2024-12-22
/content/10.2807/1560-7917.ES.2019.24.36.1900528
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References

  1. Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey D, et al. Sexually transmitted infections: challenges ahead. Lancet Infect Dis. 2017;17(8):e235-79.  https://doi.org/10.1016/S1473-3099(17)30310-9  PMID: 28701272 
  2. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0. Basel: EUCAST; 2019. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_9.0_Breakpoint_Tables.pdf
  3. Poncin T, Fouere S, Braille A, Camelena F, Agsous M, Bebear C, et al. Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017. Euro Surveill. 2018;23(21).  https://doi.org/10.2807/1560-7917.ES.2018.23.21.1800264  PMID: 29845928 
  4. Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19(5):455-77.  https://doi.org/10.1089/cmb.2012.0021  PMID: 22506599 
  5. Gurevich A, Saveliev V, Vyahhi N, Tesler G. QUAST: quality assessment tool for genome assemblies. Bioinformatics. 2013;29(8):1072-5.  https://doi.org/10.1093/bioinformatics/btt086  PMID: 23422339 
  6. Unemo M, Dillon J-AR. Review and international recommendation of methods for typing Neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology. Clin Microbiol Rev. 2011;24(3):447-58.  https://doi.org/10.1128/CMR.00040-10  PMID: 21734242 
  7. Demczuk W, Sidhu S, Unemo M, Whiley DM, Allen VG, Dillon JR, et al. Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains. J Clin Microbiol. 2017;55(5):1454-68.  https://doi.org/10.1128/JCM.00100-17  PMID: 28228492 
  8. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. High-level cefixime-and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012;56(3):1273-80.  https://doi.org/10.1128/AAC.05760-11 
  9. Eyre DW, Town K, Street T, Barker L, Sanderson N, Cole MJ, et al. Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018. Euro Surveill. 2019;24(10).  https://doi.org/10.2807/1560-7917.ES.2019.24.10.1900147  PMID: 30862336 
  10. Golparian D, Rose L, Lynam A, Mohamed A, Bercot B, Ohnishi M, et al. Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018. Euro Surveill. 2018;23(47).  https://doi.org/10.2807/1560-7917.ES.2018.23.47.1800617  PMID: 30482267 
  11. Nakayama S, Shimuta K, Furubayashi K, Kawahata T, Unemo M, Ohnishi M. New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan. Antimicrob Agents Chemother. 2016;60(7):4339-41.  https://doi.org/10.1128/AAC.00504-16  PMID: 27067334 
  12. Treangen TJ, Ondov BD, Koren S, Phillippy AM. The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. Genome Biol. 2014;15(11):524.  https://doi.org/10.1186/s13059-014-0524-x  PMID: 25410596 
  13. Letunic I, Bork P. Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Nucleic Acids Res. 2016;44(W1):W242-5.  https://doi.org/10.1093/nar/gkw290  PMID: 27095192 
  14. Lahra MM, Martin I, Demczuk W, Jennison AV, Lee K-I, Nakayama S-I, et al. Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain. Emerg Infect Dis. 2018;24(4).  https://doi.org/10.3201/eid2404.171873  PMID: 29553335 
  15. Unemo M, Shafer WM. Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future. Clin Microbiol Rev. 2014;27(3):587-613.  https://doi.org/10.1128/CMR.00010-14  PMID: 24982323 
  16. Terkelsen D, Tolstrup J, Johnsen CH, Lund O, Larsen HK, Worning P, et al. Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017. Euro Surveill. 2017;22(42).  https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659  PMID: 29067905 
  17. World Health Organization Regional Office for the Western Pacific Region (WHO/WPR). Gonococcal antimicrobial resistance in the Western Pacific Region [fact sheet]. Manila: WHO/WPR; 2017. Available from: http://iris.wpro.who.int/handle/10665.1/13688.
  18. Beauté J, Cowan S, Hiltunen-Back E, Kløvstad H, Velicko I, Spiteri G. Travel-associated gonorrhoea in four Nordic countries, 2008 to 2013. Euro Surveill. 2017;22(20):30537.  https://doi.org/10.2807/1560-7917.ES.2017.22.20.30537  PMID: 28537548 
  19. Ansart S, Hochedez P, Perez L, Bricaire F, Caumes E. Sexually transmitted diseases diagnosed among travelers returning from the tropics. J Travel Med. 2009;16(2):79-83.  https://doi.org/10.1111/j.1708-8305.2008.00279.x  PMID: 19335805 
  20. Janier M, Lassau F, Dupin N, Bouscarat F, Pelletier F, Alcaraz I, et al. Recommandations diagnostiques et thérapeutiques pour les Maladies Sexuellement Transmissibles. [Diagnosis and therapeutic recommendations for sexually transmitted diseases]. Paris: Section MST/Sida de la Société Française de Dermatologie; February 2016. French. Available from: https://www.sfdermato.org/media/image/upload-editor/files/Guidelines%202016(1).pdf
  21. British Association for Sexual Health and HIV (BASHH). National guideline for the management of infection with Neisseria gonorrhoeae (2019). Cheshire: BASHH. [Accessed 12 Mar 2019]. Available from: https://www.bashhguidelines.org/media/1208/gc-2019.pdf
  22. Davido B, Bouchand F, Tritz T, Makhloufi S. Why should 1 gram of ceftriaxone monotherapy be considered as a therapeutic option in gonococcal sexually transmitted diseases? Clin Microbiol Infect. 2016;22(11):903-4.  https://doi.org/10.1016/j.cmi.2016.07.002  PMID: 27404364 
Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Thibaut+Poncin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Poncin Thibaut</a>, <a href="/search?value1=Manel+Merimeche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Merimeche Manel</a>, <a href="/search?value1=Aymeric+Braille&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Braille Aymeric</a>, <a href="/search?value1=Mary+Mainardis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mainardis Mary</a>, <a href="/search?value1=C%C3%A9cile+Bebear&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bebear Cécile</a>, <a href="/search?value1=Herv%C3%A9+Jacquier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jacquier Hervé</a>, <a href="/search?value1=B%C3%A9atrice+Ber%C3%A7ot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berçot Béatrice</a></span>. Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(36):pii=1900528. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.36.1900528" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.36.1900528</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Aug 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Sept 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.36.1900528
/content/10.2807/1560-7917.ES.2019.24.36.1900528
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