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Abstract

Introduction

Two vaccines available for protection against rotavirus gastroenteritis (RVGE), Rotarix and RotaTeq, have contributed to a large decrease in the incidence of paediatric diarrhoea in countries where they have been used. However, they have also led to a small increase in the risk of intussusception. We compare the number of prevented hospitalisations for RVGE to the number of vaccine-induced hospitalised intussusceptions in France. With 9.5% coverage (French 2015 estimation), vaccination was estimated to prevent, annually, a median of 1,074 hospitalisations (2.5th and 97.5th percentiles (2.5th–97.5th): 810–1,378) and 1.4 deaths (2.5th–97.5th: 1.2–1.6) from RVGE. It was also estimated to cause, annually, 5.0 hospitalisations (2.5th–97.5th: 3.2–7.7) and 0.005 deaths (2.5th–97.5th: 0.001–0.015) from intussusception. The benefit–risk ratio is therefore 214 (2.5th–97.5th: 128–362) for hospitalisations and 273 (2.5th–97.5th: 89–1,228) for deaths. Under a hypothetical 92% coverage, rotavirus vaccination with Rotarix would avoid 10,459 (2.5th–97.5th: 7,702–13,498) hospitalisations for RVGE and induce 47.0 (2.5th–97.5th: 25.1–81.4) hospitalisations for intussusception annually, thereby preventing 13.7 (2.5th–97.5th: 11.1–15.2) deaths and inducing 0.05 (2.5th–97.5th: 0.01–0.15) deaths. The benefit–risk ratio in France is similar to that of other European countries.

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2017-12-14
2024-12-22
/content/10.2807/1560-7917.ES.2017.22.50.17-00041
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A benefit–risk analysis of rotavirus vaccination, France, 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Adnane+Lamrani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lamrani Adnane</a>, <a href="/search?value1=Pascale+Tubert-Bitter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tubert-Bitter Pascale</a>, <a href="/search?value1=Catherine+Hill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hill Catherine</a>, <a href="/search?value1=Sylvie+Escolano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Escolano Sylvie</a></span>. A benefit–risk analysis of rotavirus vaccination, France, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(50):pii=17-00041. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.50.17-00041" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.50.17-00041</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 13 Jan 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 31 Jul 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.50.17-00041
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