Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis

M Jonges; A Meijer; R A Fouchier; G Koch; J Li; J C Pan; H Chen; Y L Shu; M P Koopmans

doi:10.2807/ese.18.16.20460-en

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Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis
M Jonges^1,2 , A Meijer¹ , R A Fouchier² , G Koch³ , J Li⁴ , J C Pan⁴ , H Chen⁵ , Y L Shu⁶ , M P Koopmans^1,2
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Affiliations: ¹ Department of Virology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands ² Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands ³ Central Veterinary Institute, Wageningen University and Research Center, Lelystad, the Netherlands ⁴ Hangzhou Center for Disease Control and Prevention, Hangzhou, China ⁵ National Avian Influenza Reference Laboratory, Harbin Veterinary Research Institute, Harbin, China ⁶ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

Correspondence:
M Jonges
marcel.jonges rivm.nl
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Citation style for this article: Jonges M, Meijer A, Fouchier R A, Koch G, Li J , Pan J C, Chen H, Shu Y L, Koopmans M P. Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis. Euro Surveill. 2013;18(16):pii=20460. https://doi.org/10.2807/ese.18.16.20460-en Received: 15 Apr 2013

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Abstract

The recently identified human infections with avian influenza A(H7N9) viruses in China raise important questions regarding possible source and risk to humans. Sequence comparison with an influenza A(H7N7) outbreak in the Netherlands in 2003 and an A(H7N1) epidemic in Italy in 1999-2000 suggests that widespread circulation of A(H7N9) viruses must have occurred in China. The emergence of human adaptation marker PB2 E627K in human A(H7N9) cases parallels that of the fatal A(H7N7) human case in the Netherlands. .