Fatal case of extensively drug-resistant Mycobacterium tuberculosis Beijing genotype infection in an injecting drug user, Athens, Greece, 2012

K Leuow; D Papaventsis; S Kourkoundi; P Ioannidis; S Karabela; S Tsikrika; I Marinou; A Papavasileiou; M Stone; F Drobniewski; V Paparisos; E Vogiatzakis

doi:10.2807/ese.18.12.20430-en

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Fatal case of extensively drug-resistant Mycobacterium tuberculosis Beijing genotype infection in an injecting drug user, Athens, Greece, 2012
K Leuow^1,2 , D Papaventsis^2,3 , S Kourkoundi¹ , P Ioannidis³ , S Karabela³ , S Tsikrika⁴ , I Marinou³ , A Papavasileiou⁴ , M Stone^5,6 , F Drobniewski^5,6 , V Paparisos¹ , E Vogiatzakis³
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Affiliations: ¹ HIV-Unit, ‘Andreas Sygros’ University Hospital for Dermatology and Venerology, Athens, Greece ² These authors contributed equally to this work ³ Microbiology Department, National Reference Laboratory for Mycobacteria, Athens, Greece ⁴ Clinic for Multidrug-Resistant Tuberculosis, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece ⁵ National Mycobacterium Reference Laboratory, Health Protection Agency, London, United Kingdom ⁶ Barts and the London Queen Mary’s School of Medicine and Dentistry, London, United Kingdom

Correspondence:
D Papaventsis
dpapaventsis gmail.com
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Citation style for this article: Leuow K, Papaventsis D, Kourkoundi S, Ioannidis P, Karabela S, Tsikrika S, Marinou I, Papavasileiou A, Stone M, Drobniewski F, Paparisos V, Vogiatzakis E. Fatal case of extensively drug-resistant Mycobacterium tuberculosis Beijing genotype infection in an injecting drug user, Athens, Greece, 2012. Euro Surveill. 2013;18(12):pii=20430. https://doi.org/10.2807/ese.18.12.20430-en Received: 19 Feb 2013

Abstract

We present the first fatal case of extensively drug-resistant tuberculosis (XDR-TB) in an injecting drug user (IDU) in Athens, Greece, co-infected with human immunodeficiency virus and hepatitis C virus and discuss the implications for public health. Despite immediate initiation of treatment, the patient's condition gradually deteriorated and he died 16 days after hospital admission because of multiple organ failure. The contact tracing investigation revealed no further infections among the patient's contacts. .