Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11

R Pebody; P Hardelid; D M Fleming; J McMenamin; N Andrews; C Robertson; D R Thomas; P Sebastianpillai; J Ellis; W Carman; T Wreghitt; M Zambon; J M Watson

doi:10.2807/ese.16.06.19791-en

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Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11
R Pebody¹ , P Hardelid¹ , D M Fleming² , J McMenamin³ , N Andrews¹ , C Robertson^3,4 , D R Thomas⁵ , P Sebastianpillai⁶ , J Ellis⁶ , W Carman⁷ , T Wreghitt ⁸ , M Zambon⁶ , J M Watson¹
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Affiliations: ¹ Health Protection Agency Health Protection Services – Colindale, London, United Kingdom ² Royal College of General Practitioners Research and Surveillance Centre, Birmingham, United Kingdom ³ Health Protection Scotland, Glasgow, United Kingdom ⁴ University of Strathclyde, Glasgow, United Kingdom ⁵ Public Health Wales, Cardiff, United Kingdom ⁶ Health Protection Agency Microbiology Services – Colindale, London, United Kingdom ⁷ West of Scotland Specialist Virology Centre, Glasgow, United Kingdom ⁸ Health Protection Agency Microbiology Services, Cambridge, United Kingdom

Correspondence:
R Pebody
richard.pebody HPA.org.uk
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Citation style for this article: Pebody R, Hardelid P, Fleming D M, McMenamin J, Andrews N, Robertson C, Thomas D R, Sebastianpillai P, Ellis J, Carman W, Wreghitt T, Zambon M, Watson J M. Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11 . Euro Surveill. 2011;16(6):pii=19791. https://doi.org/10.2807/ese.16.06.19791-en Received: 26 Jan 2011

Abstract

This study provides mid-season estimates of the effectiveness of 2010/11 trivalent influenza vaccine and previous vaccination with monovalent influenza A(H1N1)2009 vaccine in preventing confirmed influenza A(H1N1)2009 infection in the United Kingdom in the 2010/11 season. The adjusted vaccine effectiveness was 34% (95% CI: -10 - 60%) if vaccinated only with monovalent vaccine in the 2009/10 season; 46% (95% CI: 7 - 69%) if vaccinated only with trivalent influenza vaccine in the 2010/11 season and 63% (95% CI: 37 - 78%) if vaccinated in both seasons.