1887
Rapid communication Open Access
Like 0

Abstract

The 2024/25 influenza season in Europe is currently characterised by co-circulation of influenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses, with influenza A(H1N1)pdm09 predominating. Interim vaccine effectiveness (VE) estimates from eight European studies (17 countries) indicate an all-age influenza A VE of 32–53% in primary care and 33–56% in hospital settings, with some signals of lower VE by subtype and higher VE against influenza B (≥ 58% across settings). Where feasible, influenza vaccination should be encouraged and other prevention measures strengthened.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2025.30.7.2500102
2025-02-20
2025-02-26
/content/10.2807/1560-7917.ES.2025.30.7.2500102
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/30/7/eurosurv-30-7-2.html?itemId=/content/10.2807/1560-7917.ES.2025.30.7.2500102&mimeType=html&fmt=ahah

References

  1. Kissling E, Valenciano M, Falcao J, Larrauri A, Widgren K, Pitigoi D, et al. "I-MOVE" towards monitoring seasonal and pandemic influenza vaccine effectiveness: lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9. Euro Surveill. 2009;14(44):19388.  https://doi.org/10.2807/ese.14.44.19388-en  PMID: 19941774 
  2. Kissling E, Pozo F, Martínez-Baz I, Buda S, Vilcu A-M, Domegan L, et al. Influenza vaccine effectiveness against influenza A subtypes in Europe: Results from the 2021-2022 I-MOVE primary care multicentre study. Influenza Other Respir Viruses. 2023;17(1):e13069.  https://doi.org/10.1111/irv.13069  PMID: 36702797 
  3. Rondy M, Kissling E, Emborg HD, Gherasim A, Pebody R, Trebbien R, et al. Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies. Euro Surveill. 2018;23(9):18-00086.  https://doi.org/10.2807/1560-7917.ES.2018.23.9.18-00086  PMID: 29510782 
  4. Fukushima W, Hirota Y. Basic principles of test-negative design in evaluating influenza vaccine effectiveness. Vaccine. 2017;35(36):4796-800.  https://doi.org/10.1016/j.vaccine.2017.07.003  PMID: 28818471 
  5. Whitaker H, Findlay B, Zitha J, Goudie R, Hassell K, Evans J, et al. Interim 2023/2024 season influenza vaccine effectiveness in primary and secondary care in the United Kingdom. Influenza Other Respir Viruses. 2024;18(5):e13284.  https://doi.org/10.1111/irv.13284  PMID: 38773753 
  6. Emborg HD, Krause TG, Nielsen L, Thomsen MK, Christiansen CB, Skov MN, et al. Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment. Euro Surveill. 2016;21(14):30189.  https://doi.org/10.2807/1560-7917.ES.2016.21.14.30189  PMID: 27101732 
  7. Maurel M, Pozo F, Pérez-Gimeno G, Buda S, Sève N, Oroszi B, et al. , VEBIS study team. Influenza vaccine effectiveness in Europe: Results from the 2022-2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study. Influenza Other Respir Viruses. 2024;18(1):e13243.  https://doi.org/10.1111/irv.13243  PMID: 38204584 
  8. Rose AMC, Pozo F, Martínez-Baz I, Mazagatos C, Bossuyt N, Cauchi JP, et al. Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network. Influenza Other Respir Viruses. 2024;18(2):e13255.  https://doi.org/10.1111/irv.13255  PMID: 38403302 
  9. Firth D. Bias reduction of maximum likelihood estimates. Biometrika. 1993;80(1):27-38.  https://doi.org/10.1093/biomet/80.1.27 
  10. European Centre for Disease Prevention and Control. European Respiratory Virus Surveillance Summary (ERVISS), 2025, Week 03. 2025. Available from: https://erviss.org/
  11. World Health Organization (WHO). Global Influenza Programme. Influenza update No. 512. Geneva: WHO. [Accessed: 6 Feb 2025]. Available from: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/influenza-updates/current-influenza-update
  12. Separovic L, Zhan Y, Kaweski SE, Sabaiduc S, Carazo S, Olsha R, et al. Interim estimates of vaccine effectiveness against influenza A(H1N1)pdm09 and A(H3N2) during a delayed influenza season, Canada, 2024/25. Euro Surveill. 2025;30(4):2500059. . https://doi.org/10.2807/1560-7917.ES.2025.30.4.2500059  PMID: 39885824 
  13. WHO Regional Office for Europe (WHO/Europe), European Centre for Disease Prevention and Control (ECDC). Influenza virus characterisation. Summary report, Europe, September 2024. Copenhagen: WHO, Stockholm: ECDC; 2024. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/WHO-EURO-2024-6189-45954-76521.pdf
  14. Maurel M, Howard J, Kissling E, Pozo F, Pérez-Gimeno G, Buda S, et al. Interim 2023/24 influenza A vaccine effectiveness: VEBIS European primary care and hospital multicentre studies, September 2023 to January 2024. Euro Surveill. 2024;29(8):2400089. . https://doi.org/10.2807/1560-7917.ES.2024.29.8.2400089  PMID: 38390651 
  15. Skowronski DM, Chambers C, De Serres G, Sabaiduc S, Winter AL, Dickinson JA, et al. Serial vaccination and the antigenic distance hypothesis: effects on influenza vaccine effectiveness during A(H3N2) epidemics in Canada, 2010-2011 to 2014-2015. J Infect Dis. 2017;215(7):1059-99.  https://doi.org/10.1093/infdis/jix074  PMID: 28180277 
  16. Whitaker HJ, Willam N, Cottrell S, Goudie R, Andrews N, Evans J, et al. End of 2022/23 season influenza vaccine effectiveness in primary care in Great Britain. Influenza Other Respir Viruses. 2024;18(5):e13295.  https://doi.org/10.1111/irv.13295  PMID: 38744684 
  17. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-4.  https://doi.org/10.1001/jama.2013.281053  PMID: 24141714 
/content/10.2807/1560-7917.ES.2025.30.7.2500102
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error