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Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024
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Santtu Heinonen1,2,3
, Elina Erra4,5 , Richard Lundell6 , Aino Nyqvist1 , Pilvi Hepo-oja1 , Laura Mannonen7 , Hanna Jarva7 , Raisa Loginov7 , Erika Lindh1 , Leif Lakoma1 , Petri Kangaspunta6 , Ilkka Laaksi6 , Marjaana Pitkäpaasi6 , Carita Savolainen-Kopra1 , Simo Nikkari6 , Hanna Nohynek1 , Otto Helve1 , Eeva Ruotsalainen4,* , Niina Ikonen1,*
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland 2 Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 3 FVR – Finnish Vaccine Research, Tampere, Finland (current affiliation) 4 Division of Infectious Diseases, Inflammation Center, Helsinki University Hospital, Helsinki, Finland 5 Epidemiological Operations Unit, City of Helsinki, Helsinki, Finland 6 Centre for Military Medicine, Finnish Defence Forces, Helsinki, Finland 7 HUS Diagnostic Center, Department of Clinical Microbiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland* These authors contributed equally to this work and share last authorship.Correspondence:Santtu Heinonensanttu.heinonen thl.fi
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Citation style for this article: Heinonen Santtu, Erra Elina, Lundell Richard, Nyqvist Aino, Hepo-oja Pilvi, Mannonen Laura, Jarva Hanna, Loginov Raisa, Lindh Erika, Lakoma Leif, Kangaspunta Petri, Laaksi Ilkka, Pitkäpaasi Marjaana, Savolainen-Kopra Carita, Nikkari Simo, Nohynek Hanna, Helve Otto, Ruotsalainen Eeva, Ikonen Niina. Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024. Euro Surveill. 2025;30(7):pii=2500061. https://doi.org/10.2807/1560-7917.ES.2025.30.7.2500061 Received: 22 Jan 2025; Accepted: 20 Feb 2025
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Abstract
We report an adenovirus outbreak with unusually severe clinical presentation, particularly in military conscripts and their close contacts. During 1 February–30 June 2024, 129 patients with adenovirus infection were hospitalised, 30 were admitted to ICU, 10 required ECMO treatment and six died. Cases consisted of 75 conscripts (58.1%) and 54 civilians (41.9%). Most samples were type 7 (97/108; 89.8%); all 24 sequenced samples were subtype 7d. During 1 August–30 November 2024, 274 additional hospitalised cases were identified from registries.
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