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Abstract

We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021–2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.

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/content/10.2807/1560-7917.ES.2025.30.1.2400839
2025-01-09
2025-01-15
/content/10.2807/1560-7917.ES.2025.30.1.2400839
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Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Wanying+Sun&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sun Wanying</a>, <a href="/search?value1=Ka+Tim+Choy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Choy Ka Tim</a>, <a href="/search?value1=Ka+Man+Cheng&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cheng Ka Man</a>, <a href="/search?value1=Christopher+J+Brackman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brackman Christopher J</a>, <a href="/search?value1=Samuel+MS+Cheng&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cheng Samuel MS</a>, <a href="/search?value1=Thomas+HC+Sit&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sit Thomas HC</a>, <a href="/search?value1=Anne+CN+Tse&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tse Anne CN</a>, <a href="/search?value1=Leslie+D+Sims&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sims Leslie D</a>, <a href="/search?value1=Haogao+Gu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gu Haogao</a>, <a href="/search?value1=Amy+WY+Tang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tang Amy WY</a>, <a href="/search?value1=Andrew+NC+Wong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wong Andrew NC</a>, <a href="/search?value1=Andrew+TL+Tsang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tsang Andrew TL</a>, <a href="/search?value1=Joe+CT+Koo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koo Joe CT</a>, <a href="/search?value1=Leo+LH+Luk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Luk Leo LH</a>, <a href="/search?value1=Hui-Ling+Yen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yen Hui-Ling</a>, <a href="/search?value1=Malik+Peris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peris Malik</a>, <a href="/search?value1=Leo+LM+Poon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Poon Leo LM</a></span>. Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024. <a href="/content/ecdc">Euro Surveill.</a> 2025;30(1):pii=2400839. <a href="https://doi.org/10.2807/1560-7917.ES.2025.30.1.2400839" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2025.30.1.2400839</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Dec 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 Jan 2025 </span> </p>
/content/10.2807/1560-7917.ES.2025.30.1.2400839
/content/10.2807/1560-7917.ES.2025.30.1.2400839
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