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Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024
- Tatsuki Ikuse1 , Toshihiro Matsui1 , Kensuke Shoji1 , Naoko Kono1 , Masaki Yamada1 , Chikara Ogimi1 , Chika Takahashi2 , Takanori Funaki3 , Kentaro Ide4 , Shotaro Matsumoto4 , Reiko Ito5 , Rinshu Shimabukuro5 , Yoshihiro Gocho6 , Itaru Hayakawa7 , Takashi Ishikawa8 , Seisuke Sakamoto9 , Mureo Kasahara9 , Takashi Igarashi10
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View Affiliations Hide AffiliationsAffiliations: 1 Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan 2 Infectious Disease Control Division, Setagaya Public Health Center, Tokyo, Japan 3 Center for Research Planning and Coordination, National Institute of Infectious Diseases, Tokyo, Japan 4 Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan 5 Department of General Paediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan 6 Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan 7 Division of Neurology, National Center for Child Health and Development, Tokyo, Japan 8 Division of Immunology, National Center for Child Health and Development, Tokyo, Japan 9 Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan 10 President’s office, National Center for Child Health and Development, Tokyo, JapanKensuke Shojishoji-k ncchd.go.jp
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Citation style for this article: Ikuse Tatsuki, Matsui Toshihiro, Shoji Kensuke, Kono Naoko, Yamada Masaki, Ogimi Chikara, Takahashi Chika, Funaki Takanori, Ide Kentaro, Matsumoto Shotaro, Ito Reiko, Shimabukuro Rinshu, Gocho Yoshihiro, Hayakawa Itaru, Ishikawa Takashi, Sakamoto Seisuke, Kasahara Mureo, Igarashi Takashi. Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024. Euro Surveill. 2025;30(1):pii=2400822. https://doi.org/10.2807/1560-7917.ES.2025.30.1.2400822 Received: 16 Dec 2024; Accepted: 09 Jan 2025
Abstract
In 2022–23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. In August–November 2024, three neonatal cases of ALF with echovirus 11 (E11) were reported in Tokyo, Japan. All neonates developed irreversible multiple-organ failure and died. The E11 strain belonged to the new lineage 1, which was the same as strains isolated from neonatal ALF cases in Europe in 2022–23.
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