1887
  1. Home
  2. Eurosurveillance
  3. Volume 29, Issue 8, 22/Feb/2024
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

The dissemination of carbapenemase-producing although still at low level, should be continuously monitored. OXA-244 is emerging in Europe, mainly in . In Italy, this carbapenemase was reported from an environmental river sample in 2019. We report clinical isolates of OXA-244-producing ST131 in four patients admitted to an acute care hospital in Pavia, Italy. The association of this difficult-to-detect determinant with a globally circulating high-risk clone, ST131 is of clinical relevance.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2024.29.8.2400073
2024-02-22
2024-12-21
/content/10.2807/1560-7917.ES.2024.29.8.2400073
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/29/8/eurosurv-29-8-2.html?itemId=/content/10.2807/1560-7917.ES.2024.29.8.2400073&mimeType=html&fmt=ahah

References

  1. Potron A, Poirel L, Dortet L, Nordmann P. Characterisation of OXA-244, a chromosomally-encoded OXA-48-like β-lactamase from Escherichia coli. Int J Antimicrob Agents. 2016;47(1):102-3.  https://doi.org/10.1016/j.ijantimicag.2015.10.015  PMID: 26655033 
  2. Oteo J, Hernández JM, Espasa M, Fleites A, Sáez D, Bautista V, et al. Emergence of OXA-48-producing Klebsiella pneumoniae and the novel carbapenemases OXA-244 and OXA-245 in Spain. J Antimicrob Chemother. 2013;68(2):317-21.  https://doi.org/10.1093/jac/dks383  PMID: 23034714 
  3. Welker S, Boutin S, Miethke T, Heeg K, Nurjadi D. Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020. Euro Surveill. 2020;25(46):2001815.  https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001815  PMID: 33213685 
  4. Davidova-Gerzova L, Lausova J, Sukkar I, Nesporova K, Nechutna L, Vlkova K, et al. Hospital and community wastewater as a source of multidrug-resistant ESBL-producing Escherichia coli. Front Cell Infect Microbiol. 2023;13:1184081.  https://doi.org/10.3389/fcimb.2023.1184081  PMID: 37256105 
  5. Hammerum AM, Porsbo LJ, Hansen F, Roer L, Kaya H, Henius A, et al. Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019. Euro Surveill. 2020;25(18):1900742.  https://doi.org/10.2807/1560-7917.ES.2020.25.18.1900742  PMID: 32400363 
  6. Emeraud C, Biez L, Girlich D, Jousset AB, Naas T, Bonnin RA, et al. Screening of OXA-244 producers, a difficult-to-detect and emerging OXA-48 variant? J Antimicrob Chemother. 2020;75(8):2120-3.  https://doi.org/10.1093/jac/dkaa155  PMID: 32363407 
  7. The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters Version 13.0, valid from 2023-01-01. Växjö: EUCAST; 2023. Available from: https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_13.0_BreakBreak_Tables.pdf
  8. Seeman T, Edwards R, Goncalves da Silva A, Kiil K. Shovill. Assemble bacterial isolate genomes from Illumina paired-end reads. San Francisco; GitHub; 2020. Available from: https://github.com/tseemann/shovill
  9. Zhou Z, Alikhan NF, Mohamed K, Fan Y, Agama Study Group, Achtman M. The EnteroBase user’s guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity. Genome Res. 2020;30(1):138-52.  https://doi.org/10.1101/gr.251678.119  PMID: 31809257 
  10. AbuAlshaar A, Piazza A, Mercato A, Marchesini F, Mattioni Marchetti V, Bitar I, et al. OXA-244-producing ST131 Escherichia coli from surface and groundwaters of Pavia urban area (Po plain, Northern Italy). Front Microbiol. 2022;13:920319.  https://doi.org/10.3389/fmicb.2022.920319  PMID: 35756019 
  11. Batisti Biffignandi G, Bellinzona G, Petazzoni G, Sassera D, Zuccotti GV, Bandi C, et al. P-DOR, an easy-to-use pipeline to reconstruct bacterial outbreaks using genomics. Bioinformatics. 2023;39(9):btad571.  https://doi.org/10.1093/bioinformatics/btad571  PMID: 37701995 
  12. Kocsis B, Gulyás D, Szabó D. Emergence and dissemination of extraintestinal pathogenic high-risk international clones of Escherichia coli. Life (Basel). 2022;12(12):2077.  https://doi.org/10.3390/life12122077  PMID: 36556442 
  13. European Centre for Disease Prevention and Control (ECDC). OXA-244-producing Escherichia coli in the European Union/European Economic Area and the UK since 2013, first update – 20 July 2021. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/OXA-244-producing-E-coli-in-EU-EEA-since-2013-first-update.pdf
  14. Lindemann PC, Pedersen T, Oma DH, Janice J, Grøvan F, Chedid GM, et al. Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020. Euro Surveill. 2023;28(27):2200773.  https://doi.org/10.2807/1560-7917.ES.2023.28.27.2200773  PMID: 37410380 
  15. Falgenhauer L, Nordmann P, Imirzalioglu C, Yao Y, Falgenhauer J, Hauri AM, et al. Cross-border emergence of clonal lineages of ST38 Escherichia coli producing the OXA-48-like carbapenemase OXA-244 in Germany and Switzerland. Int J Antimicrob Agents. 2020;56(6):106157.  https://doi.org/10.1016/j.ijantimicag.2020.106157  PMID: 32919009 
Clinical isolates of ST131 blaOXA-244-positive Escherichia coli, Italy, December 2022 to July 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Aurora+Piazza&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piazza Aurora</a>, <a href="/search?value1=Marta+Corbella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Corbella Marta</a>, <a href="/search?value1=Vittoria+Mattioni+Marchetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mattioni Marchetti Vittoria</a>, <a href="/search?value1=Cristina+Merla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Merla Cristina</a>, <a href="/search?value1=Irene+Mileto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mileto Irene</a>, <a href="/search?value1=Angela+Kuka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuka Angela</a>, <a href="/search?value1=Greta+Petazzoni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petazzoni Greta</a>, <a href="/search?value1=Stefano+Gaiarsa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gaiarsa Stefano</a>, <a href="/search?value1=Roberta+Migliavacca&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Migliavacca Roberta</a>, <a href="/search?value1=Fausto+Baldanti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baldanti Fausto</a>, <a href="/search?value1=Patrizia+Cambieri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cambieri Patrizia</a></span>. Clinical isolates of ST131 blaOXA-244-positive Escherichia coli, Italy, December 2022 to July 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(8):pii=2400073. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.8.2400073" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.8.2400073</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 02 Feb 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Feb 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.8.2400073
/content/10.2807/1560-7917.ES.2024.29.8.2400073
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error