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Abstract

An outbreak of influenza A(H1N1)pdm09 viruses exhibiting cross-resistance to oseltamivir and peramivir occurred in Yokohama, Japan, in September 2024. Among 24 students in a class, 11 were diagnosed with influenza or influenza-like illness, and viruses harbouring the NA H275Y and HA Q210H substitutions were isolated from four. Deep sequencing analysis confirmed the clonal spread of these mutants. Antigenic analysis revealed differences from the vaccine strain. Continued monitoring is crucial to assess the potential for further spread of these mutant viruses.

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/content/10.2807/1560-7917.ES.2024.29.50.2400786
2024-12-12
2024-12-18
/content/10.2807/1560-7917.ES.2024.29.50.2400786
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An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Emi+Takashita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takashita Emi</a>, <a href="/search?value1=Kohei+Shimizu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shimizu Kohei</a>, <a href="/search?value1=Shuzo+Usuku&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Usuku Shuzo</a>, <a href="/search?value1=Ryuichi+Senda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Senda Ryuichi</a>, <a href="/search?value1=Ichiro+Okubo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Okubo Ichiro</a>, <a href="/search?value1=Hiroko+Morita&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morita Hiroko</a>, <a href="/search?value1=Shiho+Nagata&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nagata Shiho</a>, <a href="/search?value1=Seiichiro+Fujisaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fujisaki Seiichiro</a>, <a href="/search?value1=Hideka+Miura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miura Hideka</a>, <a href="/search?value1=Noriko+Kishida&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kishida Noriko</a>, <a href="/search?value1=Kazuya+Nakamura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nakamura Kazuya</a>, <a href="/search?value1=Masayuki+Shirakura&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shirakura Masayuki</a>, <a href="/search?value1=Masataka+Ichikawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ichikawa Masataka</a>, <a href="/search?value1=Yoko+Matsuzaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matsuzaki Yoko</a>, <a href="/search?value1=Shinji+Watanabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watanabe Shinji</a>, <a href="/search?value1=Yoshimasa+Takahashi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Takahashi Yoshimasa</a>, <a href="/search?value1=Hideki+Hasegawa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasegawa Hideki</a></span>. An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(50):pii=2400786. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.50.2400786" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.50.2400786</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Nov 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 Dec 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.50.2400786
/content/10.2807/1560-7917.ES.2024.29.50.2400786
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