1887
  1. Home
  2. Eurosurveillance
  3. Volume 29, Issue 44, 31/Oct/2024
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

COVID-19 vaccination recommendations include healthcare workers (HCWs). We measured COVID-19 vaccine effectiveness (CVE) of the autumn 2023 dose against laboratory-confirmed SARS-CoV-2 infection in a prospective cohort study of 1,305 HCWs from 13 European hospitals. Overall CVE was 22% (95% CI: −17 to 48), 49% (95% CI: −8 to 76) before and −11% (95% CI: −84 to 34) after the start of BA.2.86/JN.1 predominant circulation. Autumn 2023 COVID-19 vaccination led to a moderate-to-low reduction in SARS-CoV-2 infection incidence in HCWs. Monitoring of CVE is crucial for COVID-19 prevention.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2024.29.44.2400680
2024-10-31
2024-12-12
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.44.2400680
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/29/44/eurosurv-29-44-2.html?itemId=/content/10.2807/1560-7917.ES.2024.29.44.2400680&mimeType=html&fmt=ahah

References

  1. European Centre for Disease Prevention and Control (ECDC). ECDC-EMA statement on updating COVID-19 vaccines composition for new SARS-CoV-2 virus variants. Amsterdam: EMA; Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/news-events/ecdc-ema-statement-updating-covid-19-vaccines-composition-new-sars-cov-2-virus-variants
  2. World Health Organization (WHO). WHO roadmap on uses of COVID-19 vaccines in the context of Omicron and high population immunity. Geneva: WHO; 2023. Available from: https://iris.who.int/bitstream/handle/10665/373987/WHO-2019-nCoV-Vaccines-SAGE-Prioritization-2023.2-eng.pdf?sequence=1
  3. European Centre for Disease Prevention and Control (ECDC). The European Respiratory Virus Surveillance Summary (ERVISS). Stockholm: ECDC. [Accessed: 11 Jun 2024]. Available from: https://www.ecdc.europa.eu/en/publications-data/european-respiratory-virus-surveillance-summary-erviss
  4. European Centre for Disease Prevention and Control (ECDC). Generic protocol for ECDC studies of COVID-19 vaccine effectiveness against confirmed SARS-CoV-2 using healthcare worker cohorts, version 3.0 . Stockholm: ECDC; 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/generic-protocol-ecdc-studies-covid-19-vaccine-effectiveness
  5. European Centre for Disease Prevention and Control (ECDC). Reinfection with SARS-CoV-2: implementation of a surveillance case definition within the EU/EEA. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Reinfection-with-SARSCoV2-implementation-of-a-surveillance-case-definition.pdf
  6. Shrestha NK, Burke PC, Nowacki AS, Gordon SM. Effectiveness of the 2023-2024 Formulation of the coronavirus disease 2019 messenger RNA vaccine. Clin Infect Dis. 2024;79(2):405-1.
  7. Kirwan PD, Foulkes S, Munro K, Sparkes D, Singh J, Henry A, et al. Protection of vaccine boosters and prior infection against mild/asymptomatic and moderate COVID-19 infection in the UK SIREN healthcare worker cohort: October 2023 to March 2024. J Infect. 2024;89(5):106293.  https://doi.org/10.1016/j.jinf.2024.106293  PMID: 39343245 
  8. Link-Gelles R, Ciesla AA, Mak J, Miller JD, Silk BJ, Lambrou AS, et al. Early estimates of updated 2023-2024 (Monovalent XBB.1.5) COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection attributable to co-circulating Omicron variants among immunocompetent adults - increasing community access to testing program, United States, September 2023-January 2024. MMWR Morb Mortal Wkly Rep. 2024;73(4):77-83.  https://doi.org/10.15585/mmwr.mm7304a2  PMID: 38300853 
  9. Laniece Delaunay C, Melo A, Maurel M, Mazagatos C, Goerlitz L, O’Donnell J, et al. Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023-January 2024. Vaccine. 2024;42(19):3931-7.  https://doi.org/10.1016/j.vaccine.2024.05.067  PMID: 38839521 
  10. Thadani NN, Gurev S, Notin P, Youssef N, Rollins NJ, Ritter D, et al. Learning from prepandemic data to forecast viral escape. Nature. 2023;622(7984):818-25.  https://doi.org/10.1038/s41586-023-06617-0  PMID: 37821700 
  11. Cao L, Lou J, Chan SY, Zheng H, Liu C, Zhao S, et al. Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance. Nat Med. 2022;28(8):1715-22.  https://doi.org/10.1038/s41591-022-01877-1  PMID: 35710987 
Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Camelia+Savulescu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Savulescu Camelia</a>, <a href="/search?value1=Albert+Prats-Uribe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prats-Uribe Albert</a>, <a href="/search?value1=Kim+Brolin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brolin Kim</a>, <a href="/search?value1=Anneli+Uusk%C3%BCla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Uusküla Anneli</a>, <a href="/search?value1=Colm+Bergin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bergin Colm</a>, <a href="/search?value1=Catherine+Fleming&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fleming Catherine</a>, <a href="/search?value1=Rita+Murri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Murri Rita</a>, <a href="/search?value1=Viesturs+Zvirbulis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zvirbulis Viesturs</a>, <a href="/search?value1=Dace+Zavadska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zavadska Dace</a>, <a href="/search?value1=Vania+Gaio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gaio Vania</a>, <a href="/search?value1=Corneliu+P+Popescu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Popescu Corneliu P</a>, <a href="/search?value1=Raluca+Hrisca&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hrisca Raluca</a>, <a href="/search?value1=Maria+Cisneros&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cisneros Maria</a>, <a href="/search?value1=Miriam+Latorre-Mill%C3%A1n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Latorre-Millán Miriam</a>, <a href="/search?value1=Liis+Lohur&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lohur Liis</a>, <a href="/search?value1=Jonathan+McGrath&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McGrath Jonathan</a>, <a href="/search?value1=Lauren+Ferguson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferguson Lauren</a>, <a href="/search?value1=Katleen+De+Gaetano+Donati&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Gaetano Donati Katleen</a>, <a href="/search?value1=Ilze+Abolina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abolina Ilze</a>, <a href="/search?value1=Dagne+Gravele&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gravele Dagne</a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a>, <a href="/search?value1=Simin-Aysel+Florescu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Florescu Simin-Aysel</a>, <a href="/search?value1=Mihaela+Lazar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lazar Mihaela</a>, <a href="/search?value1=Pilar+Subirats&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Subirats Pilar</a>, <a href="/search?value1=Laura+Clusa+Cuesta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Clusa Cuesta Laura</a>, <a href="/search?value1=Jacklyn+Sui&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sui Jacklyn</a>, <a href="/search?value1=Claire+Kenny&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kenny Claire</a>, <a href="/search?value1=Rosaria+Santangelo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Santangelo Rosaria</a>, <a href="/search?value1=Dainis+Krievins&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krievins Dainis</a>, <a href="/search?value1=Elza+Anna+Barzdina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barzdina Elza Anna</a>, <a href="/search?value1=Camila+Valadas+Henriques&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valadas Henriques Camila</a>, <a href="/search?value1=Alma+Gabriela+Kosa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kosa Alma Gabriela</a>, <a href="/search?value1=Saftica-Mariana+Pohrib&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pohrib Saftica-Mariana</a>, <a href="/search?value1=Carmen+Mu%C3%B1oz-Almagro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muñoz-Almagro Carmen</a>, <a href="/search?value1=Ana+Milagro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Milagro Ana</a>, <a href="/search?value1=Sabrina+Bacci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bacci Sabrina</a>, <a href="/search?value1=Anthony+Nardone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nardone Anthony</a>, <a href="/search?value1=VEBIS+HCW+VE+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">VEBIS HCW VE study group</a></span>. Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(44):pii=2400680. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.44.2400680" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.44.2400680</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Oct 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 31 Oct 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.44.2400680
/content/10.2807/1560-7917.ES.2024.29.44.2400680
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error