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Abstract

We report a considerable increase in enterovirus D68 (EV-D68) cases since July 2024, culminating in an ongoing outbreak of acute respiratory infections in northern Italy, accounting for nearly 90% of all enterovirus infections. The outbreak was identified by community- and hospital-based surveillance systems, detecting EV-D68 in individuals with mild-to-severe respiratory infections. These strains belonged to B3 and a divergent A2 lineage. An increase in adult cases was observed. Enhanced surveillance and molecular characterisation of EV-D68 across Europe are needed.

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/content/10.2807/1560-7917.ES.2024.29.41.2400645
2024-10-10
2024-12-22
/content/10.2807/1560-7917.ES.2024.29.41.2400645
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References

  1. Uprety P, Curtis D, Elkan M, Fink J, Rajagopalan R, Zhao C, et al. Association of enterovirus D68 with acute flaccid myelitis, Philadelphia, Pennsylvania, USA, 2009-2018. Emerg Infect Dis. 2019;25(9):1676-82.  https://doi.org/10.3201/eid2509.190468  PMID: 31407660 
  2. Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H, Enterovirus study collaborators. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study. Lancet Infect Dis. 2020;20(3):350-61.  https://doi.org/10.1016/S1473-3099(19)30566-3  PMID: 31870905 
  3. Simoes MP, Hodcroft EB, Simmonds P, Albert J, Alidjinou EK, Ambert-Balay K, et al. Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study. J Infect Dis. 2024;230:jiae154.; Epub ahead of print.  https://doi.org/10.1093/infdis/jiae154  PMID: 38547499 
  4. Piralla A, Girello A, Premoli M, Baldanti F. A new real-time reverse transcription-PCR assay for detection of human enterovirus 68 in respiratory samples. J Clin Microbiol. 2015;53(5):1725-6.  https://doi.org/10.1128/JCM.03691-14  PMID: 25694533 
  5. Poelman R, Schuffenecker I, Van Leer-Buter C, Josset L, Niesters HGM, Lina B, et al. European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014. J Clin Virol. 2015;71:1-9.  https://doi.org/10.1016/j.jcv.2015.07.296  PMID: 26364237 
  6. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704.  https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  7. Wisdom A, Leitch EC, Gaunt E, Harvala H, Simmonds P. Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C. J Clin Microbiol. 2009;47(12):3958-67.  https://doi.org/10.1128/JCM.00993-09  PMID: 19828751 
  8. Giardina F, Romano G, Ferrari G, Pellegrinelli L, Seiti A, Galli C, et al. A newly developed whole genome sequencing protocol enables early tracking of enterovirus D68 molecular evolution. https://doi.org/10.1101/2024.09.30.615419 
  9. Borges V, Pinheiro M, Pechirra P, Guiomar R, Gomes JP. INSaFLU: an automated open web-based bioinformatics suite "from-reads" for influenza whole-genome-sequencing-based surveillance. Genome Med. 2018;10(1):46.  https://doi.org/10.1186/s13073-018-0555-0  PMID: 29954441 
  10. Gilrane VL, Zhuge J, Huang W, Nolan SM, Dhand A, Yin C, et al. Biennial upsurge and molecular epidemiology of enterovirus D68 infection in New York, USA, 2014 to 2018. J Clin Microbiol. 2020;58(9):e00284-20.  https://doi.org/10.1128/JCM.00284-20  PMID: 32493783 
  11. Kramer R, Sabatier M, Wirth T, Pichon M, Lina B, Schuffenecker I, et al. Molecular diversity and biennial circulation of enterovirus D68: a systematic screening study in Lyon, France, 2010 to 2016. Euro Surveill. 2018;23(37):1700711.  https://doi.org/10.2807/1560-7917.ES.2018.23.37.1700711  PMID: 30229724 
  12. Benschop KS, Albert J, Anton A, Andrés C, Aranzamendi M, Armannsdóttir B, et al. Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021. Euro Surveill. 2021;26(45):2100998.  https://doi.org/10.2807/1560-7917.ES.2021.26.45.2100998  PMID: 34763750 
  13. Andrés C, Vila J, Creus-Costa A, Piñana M, González-Sánchez A, Esperalba J, et al. Enterovirus D68 in hospitalized children, Barcelona, Spain, 2014-2021. Emerg Infect Dis. 2022;28(7):1327-31.  https://doi.org/10.3201/eid2807.220264  PMID: 35731133 
  14. Katoh K, Standley DM. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol. 2013;30(4):772-80.  https://doi.org/10.1093/molbev/mst010  PMID: 23329690 
  15. Minh BQ, Schmidt HA, Chernomor O, Schrempf D, Woodhams MD, von Haeseler A, et al. IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era. Mol Biol Evol. 2020;37(5):1530-4.  https://doi.org/10.1093/molbev/msaa015  PMID: 32011700 
Enhanced laboratory surveillance of respiratory infection disclosed the rapid rise of enterovirus D68 cases, northern Italy, August to September 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Elena+Pariani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pariani Elena</a>, <a href="/search?value1=Antonio+Piralla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piralla Antonio</a>, <a href="/search?value1=Laura+Pellegrinelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pellegrinelli Laura</a>, <a href="/search?value1=Federica+Giardina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giardina Federica</a>, <a href="/search?value1=Vincenzo+Navobi+Porrello&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Porrello Vincenzo Navobi</a>, <a href="/search?value1=Greta+Romano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Romano Greta</a>, <a href="/search?value1=Cristina+Galli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galli Cristina</a>, <a href="/search?value1=Laura+Sandri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandri Laura</a>, <a href="/search?value1=Guglielmo+Ferrari&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferrari Guglielmo</a>, <a href="/search?value1=Sandro+Binda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Binda Sandro</a>, <a href="/search?value1=Luigi+Vezzosi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vezzosi Luigi</a>, <a href="/search?value1=Gabriele+Del+Castillo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Del Castillo Gabriele</a>, <a href="/search?value1=Sabrina+Buoro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buoro Sabrina</a>, <a href="/search?value1=Danilo+Cereda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cereda Danilo</a>, <a href="/search?value1=Fausto+Baldanti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baldanti Fausto</a>, <a href="/search?value1=Respiratory+viruses+pandemic+preparedness+group+Lombardy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Respiratory viruses pandemic preparedness group Lombardy</a></span>. Enhanced laboratory surveillance of respiratory infection disclosed the rapid rise of enterovirus D68 cases, northern Italy, August to September 2024. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(41):pii=2400645. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.41.2400645" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.41.2400645</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 30 Sept 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 Oct 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.41.2400645
/content/10.2807/1560-7917.ES.2024.29.41.2400645
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