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Abstract

Background

Brucellosis is a bacterial zoonosis causing severe illness in humans and animals and leading to economic losses in the livestock production in Türkiye and other endemic countries.

Aim

We aimed at investigating genomic differences of isolates from animals and humans in Türkiye.

Methods

We used whole genome sequencing (WGS) to assess the genetic diversity of isolates from 41 provinces in Türkiye and compared with isolates from other countries. We applied allele-based typing and core genome single nucleotide polymorphism (cgSNP) determination.

Results

Of the 106 Turkish isolates included, 57 were and 49 were . One and two isolates were identified as vaccine strains. Most (n = 55) isolates clustered in three major branches, with no spatial discernible pattern. Of the isolates 48 were assigned to the Eastern Mediterranean lineage with no discernible patterns between host species, location and sampling date. The Turkish isolates clustered with isolates from neighbouring countries such as Greece and Syria, but some also with isolates from human patients in European countries, like Germany, Norway and Sweden, suggesting that the source may be travel-related.

Conclusion

Several and lineages are circulating in Türkiye. To decrease the prevalence and prevent brucellosis in animals and humans, stricter control measures are needed, particularly in areas where humans and animals have close contact. Furthermore, illegal transportation of animals across borders should be more closely controlled and regulated.

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2024-09-19
2024-11-23
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Genomic analysis of Brucella isolates from animals and humans, Türkiye, 2010 to 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kadir+Akar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Akar Kadir</a>, <a href="/search?value1=Hanka+Brangsch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brangsch Hanka</a>, <a href="/search?value1=Tariq+Jamil&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jamil Tariq</a>, <a href="/search?value1=G%C3%BClseren++Y%C4%B1ld%C4%B1z+%C3%96z&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yıldız Öz Gülseren </a>, <a href="/search?value1=Emin+Ayhan+Baklan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baklan Emin Ayhan</a>, <a href="/search?value1=Buket+Ero%C4%9Flu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eroğlu Buket</a>, <a href="/search?value1=Eray+At%C4%B1l&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Atıl Eray</a>, <a href="/search?value1=Sevil+Erdenlig+G%C3%BCrbilek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Erdenlig Gürbilek Sevil</a>, <a href="/search?value1=Oktay+Keskin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Keskin Oktay</a>, <a href="/search?value1=Osman+Ya%C5%9Far+Tel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tel Osman Yaşar</a>, <a href="/search?value1=Ayfer+G%C3%BCll%C3%BC+Y%C3%BCcetepe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yücetepe Ayfer Güllü</a>, <a href="/search?value1=Vassilios+Sandalakis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandalakis Vassilios</a>, <a href="/search?value1=Evridiki+Boukouvala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boukouvala Evridiki</a>, <a href="/search?value1=Anna+Psaroulaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Psaroulaki Anna</a>, <a href="/search?value1=Ashraf+A+Abd+El+Tawab&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abd El Tawab Ashraf A</a>, <a href="/search?value1=Falk+Melzer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Melzer Falk</a>, <a href="/search?value1=Mathias+W+Pletz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pletz Mathias W</a>, <a href="/search?value1=Heinrich+Neubauer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Neubauer Heinrich</a>, <a href="/search?value1=Gamal+Wareth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wareth Gamal</a></span>. Genomic analysis of Brucella isolates from animals and humans, Türkiye, 2010 to 2020. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(38):pii=2400105. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.38.2400105" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.38.2400105</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Feb 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Apr 2024 </span> </p>
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