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SDG 3: HIV/AIDS

Abstract

Background

In the Netherlands, HIV pre-exposure prophylaxis (PrEP) has been available since 2019. However, the extent of PrEP use prior to HIV diagnosis and development of PrEP-resistance-associated mutations (RAMs) is not known.

Aim

We assessed prior PrEP use and potential transmission of PrEP RAMs among men who have sex with men (MSM) and transgender persons (TGP) with a new HIV diagnosis in the Netherlands.

Methods

Data on prior PrEP use between 1 January 2018 and 31 December 2022 were available from the Dutch national ATHENA cohort. We assessed proportion of prior PrEP use, detected PrEP associated RAMs and assessed potential onward transmission of RAMs between 2010 and 2022 using a maximum likelihood tree.

Results

Data on prior PrEP use were available for 583/1,552 (36.3%) individuals, with 16% (94/583) reporting prior PrEP use. In 489 individuals reporting no prior PrEP use, 51.5% did not use PrEP due to: low HIV-risk perception (29%), no access (19.1%), personal preference (13.1%), and being unaware of PrEP (19.1%). For PrEP users, 13/94 (13.8%) harboured a M184V/I mutation, of whom two also harboured a K65R mutation. In people with a recent HIV infection, detection of PrEP RAMs increased from 0.23% (2/862) before 2019 to 4.11% (9/219) from 2019. We found no evidence of onward transmission of PrEP RAMs.

Conclusion

The prevalence of PrEP-associated RAMs has increased since PrEP became available in the Netherlands. More widespread access to PrEP and retaining people in PrEP programmes when still at substantial risk is crucial to preventing new HIV infections.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2024-09-19
2024-12-25
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Oral HIV pre-exposure prophylaxis use and resistance-associated mutations among men who have sex with men and transgender persons newly diagnosed with HIV in the Netherlands: results from the ATHENA cohort, 2018 to 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Vita+W+Jongen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jongen Vita W</a>, <a href="/search?value1=Daniela+Bezemer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bezemer Daniela</a>, <a href="/search?value1=Ard+van+Sighem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Sighem Ard</a>, <a href="/search?value1=Anders+Boyd&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boyd Anders</a>, <a href="/search?value1=Casper+Rokx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rokx Casper</a>, <a href="/search?value1=Karin+Grintjes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grintjes Karin</a>, <a href="/search?value1=Aafke+Cents-Bosma&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cents-Bosma Aafke</a>, <a href="/search?value1=Eline+Op+de+Coul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Op de Coul Eline</a>, <a href="/search?value1=Birgit+van+Benthem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Benthem Birgit</a>, <a href="/search?value1=Annemarie+Wensing&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wensing Annemarie</a>, <a href="/search?value1=Ferdinand+WNM+Wit&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wit Ferdinand WNM</a>, <a href="/search?value1=Marc+van+der+Valk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Valk Marc</a>, <a href="/search?value1=on+behalf+of+the+ATHENA+national+observational+HIV+cohort&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the ATHENA national observational HIV cohort</a></span>. Oral HIV pre-exposure prophylaxis use and resistance-associated mutations among men who have sex with men and transgender persons newly diagnosed with HIV in the Netherlands: results from the ATHENA cohort, 2018 to 2022. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(38):pii=2400083. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.38.2400083" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.38.2400083</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 06 Feb 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Jun 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.38.2400083
/content/10.2807/1560-7917.ES.2024.29.38.2400083
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