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Abstract

Background

The war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related to Ukrainian patients.

Aim

To investigate the genomic epidemiology of New Delhi metallo-β-lactamase (NDM)-producing from Ukrainian patients among European countries.

Methods

Whole-genome sequencing of 66 isolates sampled in 2022–2023 in 10 European countries enabled whole-genome multilocus sequence typing (wgMLST), identification of resistance genes, replicons, and plasmid reconstructions. Five -carrying- isolates underwent antimicrobial susceptibility testing (AST). Transferability to of a -carrying plasmid from a patient strain was assessed. Epidemiological characteristics of patients with NDM-producing were gathered by questionnaire.

Results

wgMLST of the 66 isolates revealed two genetic clusters unrelated to Ukraine and three linked to Ukrainian patients. Of these three, two comprised -carrying- and the third -carrying- The clusters (PstCluster-001, n = 22 isolates; PstCluster-002, n = 8 isolates) comprised strains from seven and four countries, respectively. The cluster (PstCluster-003) included 13 isolates from six countries. PstCluster-001 and PstCluster-002 isolates carried an MDR plasmid harbouring , , and , which was transferrable and, for some Ukrainian patients, shared by other Enterobacterales. AST revealed PstCluster-001 isolates to be extensively drug-resistant (XDR), but susceptible to cefiderocol and aztreonam–avibactam. Patients with data on age (n = 41) were 19–74 years old; of 49 with information on sex, 38 were male.

Conclusion

XDR were introduced into European countries, requiring increased awareness and precautions when treating patients from conflict-affected areas.

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2024-06-06
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.23.2300616
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Dissemination of extensively drug-resistant NDM-producing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sandra+Witteveen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Witteveen Sandra</a>, <a href="/search?value1=J%C3%B6rg+B+Hans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hans Jörg B</a>, <a href="/search?value1=Rados%C5%82aw+Izdebski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Izdebski Radosław</a>, <a href="/search?value1=Henrik+Hasman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasman Henrik</a>, <a href="/search?value1=%C3%98rjan+Samuelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Samuelsen Ørjan</a>, <a href="/search?value1=Laurent+Dortet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dortet Laurent</a>, <a href="/search?value1=Yvonne+Pfeifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfeifer Yvonne</a>, <a href="/search?value1=Niall+Delappe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delappe Niall</a>, <a href="/search?value1=Jes%C3%BAs+Oteo-Iglesias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oteo-Iglesias Jesús</a>, <a href="/search?value1=Dorota+%C5%BBabicka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Żabicka Dorota</a>, <a href="/search?value1=Martin+Cormican&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cormican Martin</a>, <a href="/search?value1=Mirco+Sandfort&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandfort Mirco</a>, <a href="/search?value1=Felix+Reichert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reichert Felix</a>, <a href="/search?value1=Anna+K+P%C3%B6ntinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pöntinen Anna K</a>, <a href="/search?value1=Martin+A+Fischer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fischer Martin A</a>, <a href="/search?value1=Nelianne+Verkaik&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Verkaik Nelianne</a>, <a href="/search?value1=Mar%C3%ADa+P%C3%A9rez-Vazquez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez-Vazquez María</a>, <a href="/search?value1=Niels+Pfennigwerth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfennigwerth Niels</a>, <a href="/search?value1=Anette+M+Hammerum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hammerum Anette M</a>, <a href="/search?value1=S%C3%B8ren+Hallstr%C3%B8m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hallstrøm Søren</a>, <a href="/search?value1=Marta+Biedrzycka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Biedrzycka Marta</a>, <a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>, <a href="/search?value1=Cornelia+CH+Wielders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wielders Cornelia CH</a>, <a href="/search?value1=Pawe%C5%82+Urbanowicz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Urbanowicz Paweł</a>, <a href="/search?value1=Angela+de+Haan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Haan Angela</a>, <a href="/search?value1=Karin+Westmo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westmo Karin</a>, <a href="/search?value1=Fabian+Landman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Landman Fabian</a>, <a href="/search?value1=Han+GJ+van+der+Heide&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Heide Han GJ</a>, <a href="/search?value1=Simon+Lansu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lansu Simon</a>, <a href="/search?value1=Romy+D+Zwittink&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zwittink Romy D</a>, <a href="/search?value1=Daan+W+Notermans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Notermans Daan W</a>, <a href="/search?value1=Aneta+Guzek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guzek Aneta</a>, <a href="/search?value1=Viacheslav+Kondratiuk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kondratiuk Viacheslav</a>, <a href="/search?value1=Aidyn+Salmanov&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Salmanov Aidyn</a>, <a href="/search?value1=Sebastian+Haller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haller Sebastian</a>, <a href="/search?value1=Marius+Linkevicius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Linkevicius Marius</a>, <a href="/search?value1=S%C3%B6ren+Gatermann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gatermann Sören</a>, <a href="/search?value1=Anke+Kohlenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kohlenberg Anke</a>, <a href="/search?value1=Marek+Gniadkowski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gniadkowski Marek</a>, <a href="/search?value1=Guido+Werner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Werner Guido</a>, <a href="/search?value1=Antoni+PA+Hendrickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hendrickx Antoni PA</a></span>. Dissemination of extensively drug-resistant NDM-producing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(23):pii=2300616. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.23.2300616" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.23.2300616</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Nov 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 20 Mar 2024 </span> </p>
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/content/10.2807/1560-7917.ES.2024.29.23.2300616
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