1887
Rapid communication Open Access
Like 0

Abstract

Between late 2023 and early 2024, two measles outbreaks occurred in Israel, each caused by importation of measles virus strains of respective B3 and D8 genotypes. In this study, we validate transmission pathways uncovered by epidemiological investigations using a rapid molecular approach, based on complete measles virus genomes. The presented findings support this rapid molecular approach in complementing conventional contact tracing and highlight its potential for informing public health interventions.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2024.29.16.2400202
2024-04-18
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.16.2400202
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/29/16/eurosurv-29-16_2.html?itemId=/content/10.2807/1560-7917.ES.2024.29.16.2400202&mimeType=html&fmt=ahah

References

  1. Anis E, Haas EJ, Indenbaum V, Singer SR, Warshavsky B, Rishpon S, et al. A prolonged, nationwide measles outbreak despite very high vaccination coverage in Israel, 2018-19. J Infect. 2021;83(6):678-85.  https://doi.org/10.1016/j.jinf.2021.09.025  PMID: 34626701 
  2. World Health Organization (WHO). "Eliminating measles and rubella in the WHO European Region" in the description of the outbreaks. p. 15. WHO Regional Office for Europe: Copenhagen. 2024. Available from: https://www.who.int/europe/publications/i/item/9789289060783
  3. Mulders MN. “Annex B11.2 Real-time RT-PCR Assays for the Detection of Measles Virus (MeV) N Gene RNA and Human RNase P mRNA (a cellular reference gene) using the ABI 7500 Real-Time Thermocycler”. [Accessed 1 Apr 2024]. Available from: https://www.technet-21.org/en/resources/guidance/annex-b11-2-real-time-rt-pcr-assays-for-the-detection-of-measles-virus-mev-n-gene-rna-and-human-rnase-p-mrna-a-cellular-reference-gene-using-the-abi-7500-real-time-thermocycler
  4. World Health Organization (WHO). Genetic diversity of wild-type measles viruses and the global measles nucleotide surveillance database (MeaNS). Wkly Epidemiol Rec. 2015;90(30):373-80.
  5. Penedos AR, Myers R, Hadef B, Aladin F, Brown KE. Assessment of the Utility of Whole Genome Sequencing of Measles Virus in the Characterisation of Outbreaks. PLoS One. 2015;10(11):e0143081.  https://doi.org/10.1371/journal.pone.0143081  PMID: 26569100 
  6. Bucris E, Indenbaum V, Azar R, Erster O, Haas E, Mendelson E, et al. Direct sequencing of measles virus complete genomes in the midst of a large-scale outbreak. PLoS One. 2021;16(9):e0255663.  https://doi.org/10.1371/journal.pone.0255663  PMID: 34506497 
  7. Mulders MN. “Annex C16: CDC Protocol for amplification and sequencing of measles virus MF-NCR from patient samples”. [Accessed 1 Apr 2024]. Available from: https://www.technet-21.org/en/resources/document/annex-c16-cdc-protocol-for-amplification-and-sequencing-of-measles-virus-mf-ncr-from-patient-samples
  8. Hadfield J, Megill C, Bell SM, Huddleston J, Potter B, Callender C, et al. Nextstrain: real-time tracking of pathogen evolution. Bioinformatics. 2018;34(23):4121-3.  https://doi.org/10.1093/bioinformatics/bty407  PMID: 29790939 
  9. Centers for Disease Control and Prevention (CDC). “Global Measles Outbreaks”. Atlanta: CDC. [Accessed 1 Apr 2024]. Available from: https://www.cdc.gov/globalhealth/measles/data/global-measles-outbreaks.html
/content/10.2807/1560-7917.ES.2024.29.16.2400202
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error