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Abstract

While mpox was well characterised during the 2022 global Clade IIb outbreak, little is known about persistent morbidity. We present interim results of a prospective cohort study of 95 mpox patients assessed 3–20 weeks post-symptom onset. Two-thirds of participants had residual morbidity, including 25 with persistent anorectal and 18 with genital symptoms. Loss of physical fitness, new-onset/worsened fatigue and mental health problems were reported in 36, 19 and 11 patients, respectively. These findings require attention by healthcare providers.

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/content/10.2807/1560-7917.ES.2023.28.7.2300072
2023-02-16
2024-11-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.7.2300072
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References

  1. Patrocinio-Jesus R, Peruzzu F. Monkeypox Genital Lesions. N Engl J Med. 2022;387(1):66.  https://doi.org/10.1056/NEJMicm2206893  PMID: 35704421 
  2. Yakubovsky M, Shasha D, Reich S, Tau L, Friedel N, Halutz O, et al. Mpox presenting as proctitis in men who have sex with men. Clin Infect Dis. 2023;76(3):528-30.; Epub ahead of print.  https://doi.org/10.1093/cid/ciac737  PMID: 36066470 
  3. European Centre for Disease Prevention and Control (ECDC). Joint ECDC-WHO Regional Office for Europe Mpox Surveillance Bulletin: 18 January 2023. Stockholm: ECDC. [Accessed: 30 Jan 2023]. Available from: https://monkeypoxreport.ecdc.europa.eu
  4. Mahtani AU, Engome YM, Haider M, Vu TM, Delp C, Katayifci EC, et al. Paraphimosis as a complication of monkeypox infection. J Surg Case Rep. 2022;2022(11):rjac533.  https://doi.org/10.1093/jscr/rjac533  PMID: 36452291 
  5. Davido B, D’anglejan E, Jourdan J, Robinault A, Davido G. Monkeypox 2022 outbreak: cases with exclusive genital lesions. J Travel Med. 2022;29(6):taac077.  https://doi.org/10.1093/jtm/taac077  PMID: 35699601 
  6. Fink DL, Callaby H, Luintel A, Beynon W, Bond H, Lim EY, et al. , Specialist and High Consequence Infectious Diseases Centres Network for Monkeypox. Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study. Lancet Infect Dis. 2022;S1473-3099(22):00806-4.; Epub ahead of print.  https://doi.org/10.1016/S1473-3099(22)00806-4  PMID: 36566771 
  7. Miller MJ, Cash-Goldwasser S, Marx GE, Schrodt CA, Kimball A, Padgett K, et al. , CDC Severe Monkeypox Investigations Team. Severe monkeypox in hospitalized patients - United States, August 10-October 10, 2022. MMWR Morb Mortal Wkly Rep. 2022;71(44):1412-7.  https://doi.org/10.15585/mmwr.mm7144e1  PMID: 36327164 
  8. Hens M, Brosius I, Berens-Riha N, Coppens J, Van Gestel L, Rutgers J, et al. Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak. New Microbes New Infect. 2023;101093.  https://doi.org/10.1016/j.nmni.2023.101093 
  9. World Health Organization (WHO). Clinical management and infection prevention and control for monkeypox: Interim rapid response guidance, 10 June 2022. Geneva: WHO; 2022. Available from: https://www.who.int/publications/i/item/WHO-MPX-Clinical-and-IPC-2022.1
  10. White PD, Thomas JM, Kangro HO, Bruce-Jones WD, Amess J, Crawford DH, et al. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Lancet. 2001;358(9297):1946-54.  https://doi.org/10.1016/S0140-6736(01)06961-6  PMID: 11747919 
  11. Löwe B, Andresen V, Fraedrich K, Gappmayer K, Wegscheider K, Treszl A, et al. Psychological outcome, fatigue, and quality of life after infection with shiga toxin-producing Escherichia coli O104. Clin Gastroenterol Hepatol. 2014;12(11):1848-55.  https://doi.org/10.1016/j.cgh.2014.02.035  PMID: 24632347 
  12. Seet RCS, Quek AML, Lim ECH. Post-infectious fatigue syndrome in dengue infection. J Clin Virol. 2007;38(1):1-6.  https://doi.org/10.1016/j.jcv.2006.10.011  PMID: 17137834 
  13. Mehandru S, Merad M. Pathological sequelae of long-haul COVID. Nat Immunol. 2022;23(2):194-202.  https://doi.org/10.1038/s41590-021-01104-y  PMID: 35105985 
  14. Sigera PC, Rajapakse S, Weeratunga P, De Silva NL, Gomes L, Malavige GN, et al. Dengue and post-infection fatigue: findings from a prospective cohort-the Colombo Dengue Study. Trans R Soc Trop Med Hyg. 2021;115(6):669-76.  https://doi.org/10.1093/trstmh/traa110  PMID: 33099653 
  15. Moschese D, Farinacci D, Pozza G, Ciccullo A, Cossu MV, Giacomelli A, et al. Is smallpox vaccination protective against human monkeypox? J Med Virol. 2023;95(1):e28077.  https://doi.org/10.1002/jmv.28077  PMID: 35993271 
  16. Hoffmann C, Wolf E, Jessen H, Bickel M, Boesecke C, DAIG and DAGNAE. Is there any evidence for milder courses of monkeypox virus infections with childhood smallpox vaccination? Infection. 2022; Epub ahead of print.  https://doi.org/10.1007/s15010-022-01923-7  PMID: 36125626 
  17. Young J, Badgery-Parker T, Dobbins T, Jorgensen M, Gibbs P, Faragher I, et al. Comparison of ECOG/WHO performance status and ASA score as a measure of functional status. J Pain Symptom Manage. 2015;49(2):258-64.  https://doi.org/10.1016/j.jpainsymman.2014.06.006  PMID: 24996034 
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