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Abstract

We used data of 32,542 prospective cohort study participants who previously received primary and one or two monovalent booster COVID-19 vaccinations. Between 26 September and 19 December 2022, relative effectiveness of bivalent original/Omicron BA.1 vaccination against self-reported Omicron SARS-CoV-2 infection was 31% in 18–59-year-olds and 14% in 60–85-year-olds. Protection of Omicron infection was higher than of bivalent vaccination without prior infection. Although bivalent booster vaccination increases protection against COVID-19 hospitalisations, we found limited added benefit in preventing SARS-CoV-2 infection.

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/content/10.2807/1560-7917.ES.2023.28.7.2300087
2023-02-16
2024-11-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.7.2300087
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Effectiveness of bivalent mRNA booster vaccination against SARS-CoV-2 Omicron infection, the Netherlands, September to December 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Anne+J+Huiberts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huiberts Anne J</a>, <a href="/search?value1=Brechje+de+Gier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Gier Brechje</a>, <a href="/search?value1=Christina+E+Hoeve&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoeve Christina E</a>, <a href="/search?value1=Hester+E+de+Melker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Melker Hester E</a>, <a href="/search?value1=Susan+JM+Hahn%C3%A9&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hahné Susan JM</a>, <a href="/search?value1=Gerco+den+Hartog&option1=author&noRedirect=true" class="nonDisambigAuthorLink">den Hartog Gerco</a>, <a href="/search?value1=Janneke+HHM+van+de+Wijgert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van de Wijgert Janneke HHM</a>, <a href="/search?value1=Susan+van+den+Hof&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van den Hof Susan</a>, <a href="/search?value1=Mirjam+J+Knol&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Knol Mirjam J</a></span>. Effectiveness of bivalent mRNA booster vaccination against SARS-CoV-2 Omicron infection, the Netherlands, September to December 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(7):pii=2300087. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.7.2300087" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.7.2300087</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 02 Feb 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 16 Feb 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.7.2300087
/content/10.2807/1560-7917.ES.2023.28.7.2300087
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