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Abstract

Introduction

The I-MOVE-COVID-19 and VEBIS hospital networks have been measuring COVID-19 vaccine effectiveness (VE) in participating European countries since early 2021.

Aim

We aimed to measure VE against PCR-confirmed SARS-CoV-2 in patients ≥ 20 years hospitalised with severe acute respiratory infection (SARI) from December 2021 to July 2022 (Omicron-dominant period).

Methods

In both networks, 46 hospitals (13 countries) follow a similar test-negative case–control protocol. We defined complete primary series vaccination (PSV) and first booster dose vaccination as last dose of either vaccine received ≥ 14 days before symptom onset (stratifying first booster into received < 150 and ≥ 150 days after last PSV dose). We measured VE overall, by vaccine category/product, age group and time since first mRNA booster dose, adjusting by site as a fixed effect, and by swab date, age, sex, and presence/absence of at least one commonly collected chronic condition.

Results

We included 2,779 cases and 2,362 controls. The VE of all vaccine products combined against hospitalisation for laboratory-confirmed SARS-CoV-2 was 43% (95% CI: 29–54) for complete PSV (with last dose received ≥ 150 days before onset), while it was 59% (95% CI: 51–66) after addition of one booster dose. The VE was 85% (95% CI: 78–89), 70% (95% CI: 61–77) and 36% (95% CI: 17–51) for those with onset 14–59 days, 60–119 days and 120–179 days after booster vaccination, respectively.

Conclusions

Our results suggest that, during the Omicron period, observed VE against SARI hospitalisation improved with first mRNA booster dose, particularly for those having symptom onset < 120 days after first booster dose.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2023-11-23
2024-11-21
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Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022
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href="/search?value1=Petr+Husa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Husa Petr</a>, <a href="/search?value1=Nassera+Aouali&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aouali Nassera</a>, <a href="/search?value1=George+Panagiotakopoulos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Panagiotakopoulos George</a>, <a href="/search?value1=Kristin+Tolksdorf&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tolksdorf Kristin</a>, <a href="/search?value1=Judit+Krisztina+Horv%C3%A1th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horváth Judit Krisztina</a>, <a href="/search?value1=Jennifer+Howard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Howard Jennifer</a>, <a href="/search?value1=Francisco+Pozo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pozo Francisco</a>, <a href="/search?value1=Virtudes+Gallardo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gallardo Virtudes</a>, <a href="/search?value1=Diana+Nonkovi%C4%87&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nonković Diana</a>, <a href="/search?value1=Au%C5%A1ra+D%C5%BEiugyt%C4%97&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Džiugytė Aušra</a>, <a href="/search?value1=Nathalie+Bossuyt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bossuyt Nathalie</a>, <a href="/search?value1=Thomas+Demuyser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Demuyser Thomas</a>, <a href="/search?value1=R%C3%B3is%C3%ADn+Duffy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Duffy Róisín</a>, <a href="/search?value1=Liem+binh+Luong+Nguyen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Luong Nguyen Liem binh</a>, <a href="/search?value1=Irina+Kislaya&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kislaya Irina</a>, <a href="/search?value1=Iv%C3%A1n+Mart%C3%ADnez-Baz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Martínez-Baz Iván</a>, <a href="/search?value1=Giedre+Gefenaite&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gefenaite Giedre</a>, <a href="/search?value1=Mirjam+J+Knol&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Knol Mirjam J</a>, <a href="/search?value1=Corneliu+Popescu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Popescu Corneliu</a>, <a href="/search?value1=Lenka+Sou%C4%8Dkov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Součková Lenka</a>, <a href="/search?value1=Marc+Simon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simon Marc</a>, <a href="/search?value1=Stella+Michelaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michelaki Stella</a>, <a href="/search?value1=Janine+Reiche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reiche Janine</a>, <a href="/search?value1=Annam%C3%A1ria+Ferenczi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferenczi Annamária</a>, <a href="/search?value1=Concepci%C3%B3n+Delgado-Sanz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delgado-Sanz Concepción</a>, <a href="/search?value1=Zvjezdana+Lovri%C4%87+Makari%C4%87&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lovrić Makarić Zvjezdana</a>, <a href="/search?value1=John+Paul+Cauchi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cauchi John Paul</a>, <a href="/search?value1=Cyril+Barbezange&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbezange Cyril</a>, <a href="/search?value1=Els+Van+Nedervelde&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Nedervelde Els</a>, <a href="/search?value1=Joan+O%E2%80%99Donnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">O’Donnell Joan</a>, <a href="/search?value1=Christine+Durier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Durier Christine</a>, <a href="/search?value1=Raquel+Guiomar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guiomar Raquel</a>, <a href="/search?value1=Jes%C3%BAs+Castilla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Castilla Jesús</a>, <a href="/search?value1=Indr%C4%97+Jonikaite&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jonikaite Indrė</a>, <a href="/search?value1=Patricia+CJL+Bruijning-Verhagen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bruijning-Verhagen Patricia CJL</a>, <a href="/search?value1=Mihaela+Lazar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lazar Mihaela</a>, <a href="/search?value1=Regina+Demlov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Demlová Regina</a>, <a href="/search?value1=Gil+Wirtz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wirtz Gil</a>, <a href="/search?value1=Marina+Amerali&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amerali Marina</a>, <a href="/search?value1=Ralf+D%C3%BCrrwald&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dürrwald Ralf</a>, <a href="/search?value1=Mih%C3%A1ly+P%C3%A1l+Kunst%C3%A1r&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kunstár Mihály Pál</a>, <a href="/search?value1=Esther+Kissling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kissling Esther</a>, <a href="/search?value1=Sabrina+Bacci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bacci Sabrina</a>, <a href="/search?value1=Marta+Valenciano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valenciano Marta</a>, <a href="/search?value1=I-MOVE-COVID-19+hospital+study+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">I-MOVE-COVID-19 hospital study team</a>, <a href="/search?value1=VEBIS+hospital+study+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">VEBIS hospital study team</a></span>. Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(47):pii=2300187. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.47.2300187" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.47.2300187</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Mar 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 24 Jul 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.47.2300187
/content/10.2807/1560-7917.ES.2023.28.47.2300187
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