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Abstract

We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls () and two red fox kits (), were found dead in close vicinity. Comparison of viral whole genome sequences obtained from the animals identified a novel mammalian adaptation, PB2-M535I. Analysis of genetic sequences from other recent mammalian infections shows that this mutation has arisen on at least five occasions in three European countries since April 2023.

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/content/10.2807/1560-7917.ES.2023.28.42.2300526
2023-10-19
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.42.2300526
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Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Paula+Lagan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lagan Paula</a>, <a href="/search?value1=Robyn+McKenna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McKenna Robyn</a>, <a href="/search?value1=Salam+Baleed&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baleed Salam</a>, <a href="/search?value1=Bob+Hanna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hanna Bob</a>, <a href="/search?value1=Jason+Barley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barley Jason</a>, <a href="/search?value1=Shirley+McConnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McConnell Shirley</a>, <a href="/search?value1=Anastasia+Georgaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Georgaki Anastasia</a>, <a href="/search?value1=Tarja+Sironen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sironen Tarja</a>, <a href="/search?value1=Ari+Kauppinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kauppinen Ari</a>, <a href="/search?value1=Tuija+Gadd&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gadd Tuija</a>, <a href="/search?value1=Erika+Lindh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lindh Erika</a>, <a href="/search?value1=Niina+Ikonen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ikonen Niina</a>, <a href="/search?value1=Michael+J+McMenamy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMenamy Michael J</a>, <a href="/search?value1=Ken+Lemon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lemon Ken</a></span>. Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(42):pii=2300526. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.42.2300526" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.42.2300526</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Oct 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Oct 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.42.2300526
/content/10.2807/1560-7917.ES.2023.28.42.2300526
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