1887
Rapid communication Open Access
Like 0

Abstract

We analysed SARS-CoV-2 PCR Cq values from 3,183 healthcare workers who tested positive between January and August 2022. Median Cq values were lower in symptomatic than in asymptomatic HCW. The difference in Cq values between HCW with mild vs moderate/severe symptoms was statistically significant but negligibly small. To prevent nosocomial infections, all symptomatic HCW should be tested irrespective of symptom severity. This information can support decisions on testing and isolation, in the context of ongoing pressure on healthcare systems.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2023.28.4.2300007
2023-01-26
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.4.2300007
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/28/4/eurosurv-28-4-1.html?itemId=/content/10.2807/1560-7917.ES.2023.28.4.2300007&mimeType=html&fmt=ahah

References

  1. Sun J, Zheng Q, Madhira V, Olex AL, Anzalone AJ, Vinson A, et al. Association between immune dysfunction and COVID-19 breakthrough infection after SARS-CoV-2 vaccination in the US. JAMA Intern Med. 2022;182(2):153-62.  https://doi.org/10.1001/jamainternmed.2021.7024  PMID: 34962505 
  2. Puhach O, Meyer B, Eckerle I. SARS-CoV-2 viral load and shedding kinetics. Nat Rev Microbiol. 2022;1-15. PMID: 36460930 
  3. F. Hoffmann-La Roche Ltd. cobas SARS-CoV-2 Test. Basel: F. Hoffmann-La Roche Ltd. [Accessed: 29 Dec 2022]. Available from: https://diagnostics.roche.com/global/en/products/params/cobas-sars-cov-2-test.html
  4. Rijksinstituut voor Volksgezondheid en Milieu (RIVM). Varianten van het coronavirus SARS-CoV-2. [Variants of the coronavirus SARS-CoV-2]. Bilthoven: RIVM. [Accessed: 29 Dec 2022]. Dutch. Available from: https://www.rivm.nl/coronavirus-covid-19/virus/varianten
  5. Gniazdowski V, Paul Morris C, Wohl S, Mehoke T, Ramakrishnan S, Thielen P, et al. Repeated coronavirus disease 2019 molecular testing: correlation of severe acute respiratory syndrome coronavirus 2 culture with molecular assays and cycle thresholds. Clin Infect Dis. 2021;73(4):e860-9.  https://doi.org/10.1093/cid/ciaa1616  PMID: 33104776 
  6. La Scola B, Le Bideau M, Andreani J, Hoang VT, Grimaldier C, Colson P, et al. Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards. Eur J Clin Microbiol Infect Dis. 2020;39(6):1059-61.  https://doi.org/10.1007/s10096-020-03913-9  PMID: 32342252 
  7. Singanayagam A, Patel M, Charlett A, Lopez Bernal J, Saliba V, Ellis J, et al. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020. Euro Surveill. 2020;25(32):2001483.  https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483  PMID: 32794447 
  8. Saglik I, Ener B, Akalin H, Ozdemir B, Ocakoglu G, Yalcin B, et al. Association of SARS-CoV-2 cycle threshold (Ct) values with clinical course and serum biomarkers in COVID-19 patients. J Infect Dev Ctries. 2022;16(3):445-52.  https://doi.org/10.3855/jidc.15818  PMID: 35404849 
  9. Bullard J, Dust K, Funk D, Strong JE, Alexander D, Garnett L, et al. Predicting infectious severe acute respiratory syndrome coronavirus 2 from diagnostic samples. Clin Infect Dis. 2020;71(10):2663-6.  https://doi.org/10.1093/cid/ciaa638  PMID: 32442256 
  10. Kolodziej LM, Hordijk S, Koopsen J, Maas JJ, Thung HT, Spijkerman IJB, et al. Risk of SARS-CoV-2 transmission upon return to work in RNA-positive healthcare workers. J Hosp Infect. 2022;124:72-8.  https://doi.org/10.1016/j.jhin.2022.02.024  PMID: 35288252 
  11. Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, et al. Duration of shedding of culturable virus in SARS-CoV-2 Omicron (BA.1) infection. N Engl J Med. 2022;387(3):275-7.  https://doi.org/10.1056/NEJMc2202092  PMID: 35767428 
  12. Takahashi K, Ishikane M, Ujiie M, Iwamoto N, Okumura N, Sato T, et al. Duration of infectious virus shedding by SARS-CoV-2 Omicron variant-infected vaccinees. Emerg Infect Dis. 2022;28(5):998-1001.  https://doi.org/10.3201/eid2805.220197  PMID: 35290176 
/content/10.2807/1560-7917.ES.2023.28.4.2300007
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error