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Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022
- Béatrice Berçot1,2,3 , François Caméléna1,2,3 , Manel Mérimèche1,2,3 , Susanne Jacobsson4 , Ghalia Sbaa2,3 , Mary Mainardis2,3 , Cyrille Valin5 , Jean-Michel Molina6,7 , Cécile Bébéar8 , Emilie Chazelle9 , Florence Lot9 , Daniel Golparian4 , Magnus Unemo4,10
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View Affiliations Hide AffiliationsAffiliations: 1 Université Paris Cité, INSERM, IAME, Paris, France 2 APHP, Infectious Agents Department, Saint Louis Hospital, Paris, France 3 French National Reference Centre for bacterial STIs, Associated Laboratory for Gonococci, Paris, France 4 WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro, Sweden 5 Laboratoire Anse, Biogroup, Lyon, France 6 AP-HP, Hôpital Saint-Louis, Lariboisière, Département de Maladies Infectieuses et Tropicales, Paris, France 7 Université Paris Cité, UMR S976, INSERM, Paris, France 8 University of Bordeaux, USC EA 3671, Mycoplasmal and Chlamydial Infections in Humans, Bordeaux University Hospital, French National Reference Centre for Bacterial STIs, Bordeaux, France 9 Santé Publique France, French National Public Health Agency, Saint-Maurice, France 10 Institute for Global Health, University College London, London, United KingdomBéatrice Berçotbeatrice.bercot aphp.fr
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Citation style for this article: Berçot Béatrice, Caméléna François, Mérimèche Manel, Jacobsson Susanne, Sbaa Ghalia, Mainardis Mary, Valin Cyrille, Molina Jean-Michel, Bébéar Cécile, Chazelle Emilie, Lot Florence, Golparian Daniel, Unemo Magnus. Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022. Euro Surveill. 2022;27(50):pii=2200899. https://doi.org/10.2807/1560-7917.ES.2022.27.50.2200899 Received: 25 Nov 2022; Accepted: 13 Dec 2022
Abstract
We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic penA-237.001, which caused ceftriaxone resistance. penA-237.001 is 98.7% identical to penA-60.001, reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.
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