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Abstract

Modified vaccinia virus Ankara vaccine (MVA-BN; Bavarian Nordic) is recommended to contacts of mpox cases up to 14 days post-exposure but the effectiveness of this strategy is unknown. Among 108 adults (≥ 18 years old) who received one dose of MVA-BN after exposure to mpox, 11 (10%) cases of breakthrough mpox were observed. Sexual exposure was associated with the risk of breakthrough mpox (p = 0.0179). Samples taken from vaccinated breakthrough mpox cases had similar rates of infectious virus isolation than unvaccinated mpox cases.

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/content/10.2807/1560-7917.ES.2022.27.50.2200882
2022-12-15
2024-12-22
/content/10.2807/1560-7917.ES.2022.27.50.2200882
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Outcomes of post-exposure vaccination by modified vaccinia Ankara to prevent mpox (formerly monkeypox): a retrospective observational study in Lyon, France, June to August 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Yanis+Merad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Merad Yanis</a>, <a href="/search?value1=Alexandre+Gaymard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gaymard Alexandre</a>, <a href="/search?value1=Laurent+Cotte&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cotte Laurent</a>, <a href="/search?value1=Thomas+Perpoint&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Perpoint Thomas</a>, <a href="/search?value1=Dulce+Alfaiate&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alfaiate Dulce</a>, <a href="/search?value1=Matthieu+Godinot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Godinot Matthieu</a>, <a href="/search?value1=Agathe+Becker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Becker Agathe</a>, <a href="/search?value1=Olivier+Cannesson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cannesson Olivier</a>, <a href="/search?value1=Anne-Sophie+Batalla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Batalla Anne-Sophie</a>, <a href="/search?value1=Fatima+Oria-Yassir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oria-Yassir Fatima</a>, <a href="/search?value1=Sophie+Landr%C3%A9&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Landré Sophie</a>, <a href="/search?value1=Florence+Morfin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morfin Florence</a>, <a href="/search?value1=Maude+Bouscambert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bouscambert Maude</a>, <a href="/search?value1=Florent+Valour&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valour Florent</a>, <a href="/search?value1=Florence+Ader&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ader Florence</a>, <a href="/search?value1=Anne+Conrad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Conrad Anne</a></span>. Outcomes of post-exposure vaccination by modified vaccinia Ankara to prevent mpox (formerly monkeypox): a retrospective observational study in Lyon, France, June to August 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(50):pii=2200882. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.50.2200882" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.50.2200882</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Nov 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Dec 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.50.2200882
/content/10.2807/1560-7917.ES.2022.27.50.2200882
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