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Abstract

Background

The role of children in the transmission of SARS-CoV-2 during the early pandemic was unclear.

Aim

We aimed to review studies on the transmission of SARS-CoV-2 by children during the early pandemic.

Methods

We searched MEDLINE, Embase, the Cochrane Library, Europe PubMed Central and the preprint servers medRxiv and bioRxiv from 30 December 2019 to 10 August 2020. We assessed the quality of included studies using a series of questions adapted from related tools. We provide a narrative synthesis of the results.

Results

We identified 28 studies from 17 countries. Ten of 19 studies on household and close contact transmission reported low rates of child-to-adult or child-to-child transmission. Six studies investigated transmission of SARS-CoV-2 in educational settings, with three studies reporting 183 cases from 14,003 close contacts who may have contracted COVID-19 from children index cases at their schools. Three mathematical modelling studies estimated that children were less likely to infect others than adults. All studies were of low to moderate quality.

Conclusions

During the early pandemic, it appeared that children were not substantially contributing to household transmission of SARS-CoV-2. School-based studies indicated that transmission rates in this setting were low. Large-scale studies of transmission chains using data collected from contact tracing and serological studies detecting past evidence of infection would be needed to verify our findings.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2022-02-03
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.5.2001651
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References

  1. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20(5):533-4.  https://doi.org/10.1016/S1473-3099(20)30120-1  PMID: 32087114 
  2. Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-6.  https://doi.org/10.1016/j.ijsu.2020.02.034  PMID: 32112977 
  3. Choi S-H, Kim HW, Kang J-M, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-32. PMID: 32252139 
  4. Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020;20(6):689-96.  https://doi.org/10.1016/S1473-3099(20)30198-5  PMID: 32220650 
  5. Bundle N, Dave N, Pharris A, Spiteri G, Deogan C, Suk JE. COVID-19 trends and severity among symptomatic children aged 0-17 years in 10 European Union countries, 3 August 2020 to 3 October 2021. Euro Surveill. 2021;26(50):2101098.  https://doi.org/10.2807/1560-7917.ES.2021.26.50.2101098  PMID: 34915968 
  6. Centers for Disease Control and Prevention (CDC). COVID Data Tracker. Demographic trends of COVID-19 cases and deaths in the US reported to CDC. Atlanta: CDC; 2020. Available from: https://covid.cdc.gov/covid-data-tracker/#datatracker-home
  7. European Centre for Disease Prevention and Control (ECDC). COVID-19 in children and the role of school settings in COVID-19 transmission. Stockholm: ECDC; 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/children-and-school-settings-covid-19-transmission
  8. Sisk B, Cull W, Harris JM, Rothenburger A, Olson L. National trends of cases of COVID-19 in children based on US state health department data. Pediatrics. 2020;146(6):e2020027425.  https://doi.org/10.1542/peds.2020-027425  PMID: 32994175 
  9. Liu Y, Gu Z, Xia S, Shi B, Zhou XN, Shi Y, et al. What are the underlying transmission patterns of COVID-19 outbreak? An age-specific social contact characterization. EClinicalMedicine. 2020;22:100354.  https://doi.org/10.1016/j.eclinm.2020.100354  PMID: 32313879 
  10. Zhang J, Litvinova M, Liang Y, Wang Y, Wang W, Zhao S, et al. Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China. Science. 2020;368(6498):1481-6.  https://doi.org/10.1126/science.abb8001  PMID: 32350060 
  11. Viner RM, Mytton OT, Bonell C, Melendez-Torres GJ, Ward J, Hudson L, et al. Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults: a systematic review and meta-analysis. JAMA Pediatr. 2021;175(2):143-56.  https://doi.org/10.1001/jamapediatrics.2020.4573  PMID: 32975552 
  12. Davies NG, Klepac P, Liu Y, Prem K, Jit M, Eggo RM. Age-dependent effects in the transmission and control of COVID-19 epidemics. Nat Med. 2020;26(8):1205-11.  https://doi.org/10.1038/s41591-020-0962-9  PMID: 32546824 
  13. Health Information and Quality Authority (HIQA). Protocol for evidence synthesis support - COVID-19. Dublin: HIQA; 2020. Available from: https://www.hiqa.ie/sites/default/files/2020-04/Protocol-for-evidence-synthesis-support_1-4-COVID-19.pdf
  14. Garritty C, Gartlehner G, Nussbaumer-Streit B, King VJ, Hamel C, Kamel C, et al. Cochrane Rapid Reviews Methods Group offers evidence-informed guidance to conduct rapid reviews. J Clin Epidemiol. 2021;130:13-22.  https://doi.org/10.1016/j.jclinepi.2020.10.007  PMID: 33068715 
  15. Health Information and Quality Authority (HIQA). HIQA publishes COVID-19 evidence summaries to support work of the National Public Health Emergency Team. Dublin: HIQA; 2020. Available from: https://www.hiqa.ie/hiqa-news-updates/hiqa-publishes-covid-19-evidence-summaries-support-work-national-public-health
  16. Health Information and Quality Authority (HIQA). Evidence summary of potential for children to contribute to transmission of SARS-CoV-2 21 August 2020. HIQA: Dublin; 2020. Available from: https://www.hiqa.ie/reports-and-publications/health-technology-assessment/evidence-summary-spread-covid-19-children
  17. Jiehao C, Jin X, Daojiong L, Zhi Y, Lei X, Zhenghai Q, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;71(6):1547-51.  https://doi.org/10.1093/cid/ciaa198  PMID: 32112072 
  18. Wu Q, Xing Y, Shi L, Li W, Gao Y, Pan S, et al. Coinfection and other clinical characteristics of COVID-19 in children. Pediatrics. 2020;146(1):e20200961.  https://doi.org/10.1542/peds.2020-0961  PMID: 32376725 
  19. Danis K, Epaulard O, Bénet T, Gaymard A, Campoy S, Botelho-Nevers E, et al. Cluster of Coronavirus Disease 2019 (COVID-19) in the French Alps, February 2020. Clin Infect Dis. 2020;71(15):825-32.  https://doi.org/10.1093/cid/ciaa424  PMID: 32277759 
  20. Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G. COVID-19 infection in a paucisymptomatic infant: Raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 2020;55(6):E4-5.  https://doi.org/10.1002/ppul.24754  PMID: 32250049 
  21. Le HT, Nguyen LV, Tran DM, Do HT, Tran HT, Le YT, et al. The first infant case of COVID-19 acquired from a secondary transmission in Vietnam. Lancet Child Adolesc Health. 2020;4(5):405-6.  https://doi.org/10.1016/S2352-4642(20)30091-2  PMID: 32213326 
  22. Lin J, Duan J, Tan T, Fu Z, Dai J. The isolation period should be longer: Lesson from a child infected with SARS-CoV-2 in Chongqing, China. Pediatr Pulmonol. 2020;55(6):E6-9.  https://doi.org/10.1002/ppul.24763  PMID: 32243729 
  23. Qiu L, Jiao R, Zhang A, Chen X, Ning Q, Fang F, et al. A case of critically ill infant of coronavirus disease 2019 with persistent reduction of t lymphocytes. Pediatr Infect Dis J. 2020;39(7):e87-90.  https://doi.org/10.1097/INF.0000000000002720  PMID: 32379199 
  24. Posfay-Barbe KM, Wagner N, Gauthey M, Moussaoui D, Loevy N, Diana A, et al. COVID-19 in children and the dynamics of infection in families. Pediatrics. 2020;146(2):e20201576.  https://doi.org/10.1542/peds.2020-1576  PMID: 32457213 
  25. Xu X, Liu X, Wu Y. ALI ST. Close contacts and household transmission of SARS-CoV-2 in China: a content analysis based on local Heath Commissions’ public disclosures. medRxiv. 2020:2020.03.02.20029868. Preprint.
  26. Wongsawat J, Moolasart V, Srikirin P, Srijareonvijit C, Vaivong N, Uttayamakul S, et al. Risk of novel coronavirus 2019 transmission from children to caregivers: A case series. J Paediatr Child Health. 2020;56(6):984-5.  https://doi.org/10.1111/jpc.14965  PMID: 32567772 
  27. Szablewski CM, Chang KT, Brown MM, Chu VT, Yousaf AR, Anyalechi N, et al. SARS-CoV-2 transmission and infection among attendees of an overnight camp - Georgia, June 2020. MMWR Morb Mortal Wkly Rep. 2020;69(31):1023-5.  https://doi.org/10.15585/mmwr.mm6931e1  PMID: 32759921 
  28. Jung J, Hong MJ, Kim EO, Lee J, Kim MN, Kim SH. Investigation of a nosocomial outbreak of coronavirus disease 2019 in a paediatric ward in South Korea: successful control by early detection and extensive contact tracing with testing. Clin Microbiol Infect. 2020;26(11):1574-5.  https://doi.org/10.1016/j.cmi.2020.06.021  PMID: 32593744 
  29. Lucar J, Navalkele B, Becker BP, Reed CD, Parham J. Health care personnel exposure to a patient with asymptomatic SARS-CoV2 infection during a prolonged surgical intervention. Am J Infect Control. 2020;48(8):955-7.  https://doi.org/10.1016/j.ajic.2020.05.036  PMID: 32505792 
  30. Nassih H, El Fakiri K, Sab IA. Absence of evidence of transmission of coronavirus disease 2019 from a young child to mother despite prolonged contact. Indian J Pediatr. 2020;87(9):754.  https://doi.org/10.1007/s12098-020-03382-0  PMID: 32535688 
  31. Laxminarayan R, Wahl B, Dudala SR, Gopal K, Mohan B C, Neelima S, et al. Epidemiology and transmission dynamics of COVID-19 in two Indian states. Science. 2020;370(6517):691-7.  https://doi.org/10.1126/science.abd7672  PMID: 33154136 
  32. Mannheim J, Gretsch S, Layden JE, Fricchione MJ. Characteristics of hospitalized pediatric coronavirus disease 2019 cases in Chicago, Illinois, March-April 2020. J Pediatric Infect Dis Soc. 2020;9(5):519-22.  https://doi.org/10.1093/jpids/piaa070  PMID: 32479632 
  33. Somekh E, Gleyzer A, Heller E, Lopian M, Kashani-Ligumski L, Czeiger S, et al. The role of children in the dynamics of intra family coronavirus 2019 spread in densely populated area. Pediatr Infect Dis J. 2020;39(8):e202-4.  https://doi.org/10.1097/INF.0000000000002783  PMID: 32496407 
  34. van der Hoek W, Backer JA, Bodewes R, Friesema I, Meijer A, Pijnacker R, et al. De rol van kinderen in de transmissie van SARS-CoV-2. [The role of children in the transmission of SARS-CoV-2]. Dutch. Ned Tijdschr Geneeskd. 2020;164(25):D5140. PMID: 32749807 
  35. Zhu Y, Bloxham CJ, Hulme KD, Sinclair JE, Tong ZWM, Steele LE, et al. Children are unlikely to have been the primary source of household SARS-CoV-2 infections. medRxiv. 2020:2020.03.26.20044826. Preprint.
  36. Dub T, Erra E, Hagberg L, Sarvikivi E, Virta C, Jarvinen A, et al. Transmission of SARS-CoV-2 following exposure in school settings: experience from two Helsinki area exposure incidents. medRxiv. 2020:2020.07.20.20156018. Preprint . https://doi.org/10.1101/2020.07.20.20156018 
  37. Heavey L, Casey G, Kelly C, Kelly D, McDarby G. No evidence of secondary transmission of COVID-19 from children attending school in Ireland, 2020. Euro Surveill. 2020;25(21):2000903.  https://doi.org/10.2807/1560-7917.ES.2020.25.21.2000903  PMID: 32489179 
  38. Macartney K, Quinn HE, Pillsbury AJ, Koirala A, Deng L, Winkler N, et al. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study. Lancet Child Adolesc Health. 2020;4(11):807-16.  https://doi.org/10.1016/S2352-4642(20)30251-0  PMID: 32758454 
  39. Stein-Zamir C, Abramson N, Shoob H, Libal E, Bitan M, Cardash T, et al. A large COVID-19 outbreak in a high school 10 days after schools’ reopening, Israel, May 2020. Euro Surveill. 2020;25(29):2001352.  https://doi.org/10.2807/1560-7917.ES.2020.25.29.2001352  PMID: 32720636 
  40. Yoon Y, Kim K-R, Park H, Kim S, Kim YJ. Stepwise school opening and an impact on the epidemiology of COVID-19 in the children. J Korean Med Sci. 2020;35(46):e414.  https://doi.org/10.3346/jkms.2020.35.e414  PMID: 33258334 
  41. Yung CF, Kam KQ, Nadua KD, Chong CY, Tan NWH, Li J, et al. Novel coronavirus 2019 transmission risk in educational settings. Clin Infect Dis. 2021;72(6):1055-8.  https://doi.org/10.1093/cid/ciaa794  PMID: 32584975 
  42. Zhao Z, Zhu Y-Z, Xu J-W, Hu Q-Q, Lei Z, Rui J, et al. A mathematical model for estimating the age-specific transmissibility of a novel coronavirus. medRxiv. 2020:2020.03.05.20031849. Preprint . https://doi.org/10.1101/2020.03.05.20031849 
  43. Dattner I, Goldberg Y, Katriel G, Yaari R, Gal N, Miron Y, et al. The role of children in the spread of COVID-19: Using household data from Bnei Brak, Israel, to estimate the relative susceptibility and infectivity of children. medRxiv. 2020:2020.06.03.20121145. Preprint . https://doi.org/10.1101/2020.06.03.20121145 
  44. James A, Plank MJ, Hendy S, Binny RN, Lustig A, Steyn N. Model-free estimation of COVID-19 transmission dynamics from a complete outbreak. medRxiv. 2020:2020.07.21.20159335. Preprint . https://doi.org/10.1101/2020.07.21.20159335 
  45. Yung CF, Kam K-Q, Wong MSY, Maiwald M, Tan YK, Tan BH, et al. Environment and personal protective equipment tests for sars-cov-2 in the isolation room of an infant with infection. Ann Intern Med. 2020;173(3):240-2.  https://doi.org/10.7326/M20-0942  PMID: 32236490 
  46. Xu XK, Liu XF, Wu Y, Ali ST, Du Z, Bosetti P, et al. Reconstruction of transmission pairs for novel Coronavirus Disease 2019 (COVID-19) in mainland China: estimation of superspreading events, serial interval, and hazard of infection. Clin Infect Dis. 2020;71(12):3163-7.  https://doi.org/10.1093/cid/ciaa790  PMID: 32556265 
  47. Worby CJ, Chaves SS, Wallinga J, Lipsitch M, Finelli L, Goldstein E. On the relative role of different age groups in influenza epidemics. Epidemics. 2015;13:10-6.  https://doi.org/10.1016/j.epidem.2015.04.003  PMID: 26097505 
  48. Ludvigsson JF. Children are unlikely to be the main drivers of the COVID-19 pandemic - A systematic review. Acta Paediatr. 2020;109(8):1525-30.  https://doi.org/10.1111/apa.15371  PMID: 32430964 
  49. Rajmil L. Role of children in the transmission of the COVID-19 pandemic: a rapid scoping review. BMJ Paediatr Open. 2020;4(1):e000722.  https://doi.org/10.1136/bmjpo-2020-000722  PMID: 32596514 
  50. Park YJ, Choe YJ, Park O, Park SY, Kim YM, Kim J, et al. Contact tracing during coronavirus disease outbreak, South Korea, 2020. Emerg Infect Dis. 2020;26(10):2465-8.  https://doi.org/10.3201/eid2610.201315  PMID: 32673193 
  51. Cui X, Zhang T, Zheng J, Zhang J, Si P, Xu Y, et al. Children with coronavirus disease 2019: A review of demographic, clinical, laboratory, and imaging features in pediatric patients. J Med Virol. 2020;92(9):1501-10.  https://doi.org/10.1002/jmv.26023  PMID: 32418216 
  52. Garazzino S, Montagnani C, Donà D, Meini A, Felici E, Vergine G, et al. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020. Euro Surveill. 2020;25(18):2000600.  https://doi.org/10.2807/1560-7917.ES.2020.25.18.2000600  PMID: 32400362 
  53. Rahimzadeh G, Ekrami Noghabi M, Kadkhodaei Elyaderani F, Navaeifar MR, Enayati AA, Manafi Anari A, et al. COVID-19 infection in Iranian children: a case series of 9 patients. J Pediatr Rev.2020;8(2):139-44.  https://doi.org/10.32598/jpr.8.2.139 
  54. Shen Q, Guo W, Guo T, Li J, He W, Ni S, et al. Novel coronavirus infection in children outside of Wuhan, China. Pediatr Pulmonol. 2020;55(6):1424-9.  https://doi.org/10.1002/ppul.24762  PMID: 32259403 
  55. Zhen-Dong Y, Gao-Jun Z, Run-Ming J, Zhi-Sheng L, Zong-Qi D, Xiong X, et al. Clinical and transmission dynamics characteristics of 406 children with coronavirus disease 2019 in China: A review. J Infect. 2020;81(2):e11-5.  https://doi.org/10.1016/j.jinf.2020.04.030  PMID: 32360500 
  56. Leclerc QJ, Fuller NM, Knight LE, Funk S, Knight GM. What settings have been linked to SARS-CoV-2 transmission clusters? Wellcome Open Res. 2020;5:83.  https://doi.org/10.12688/wellcomeopenres.15889.2  PMID: 32656368 
  57. Contejean A, Leporrier J, Canouï E, Alby-Laurent F, Lafont E, Beaudeau L, et al. Comparing dynamics and determinants of severe acute respiratory syndrome coronavirus 2 transmissions among healthcare workers of adult and pediatric settings in central Paris. Clin Infect Dis. 2021;72(2):257-64.  https://doi.org/10.1093/cid/ciaa977  PMID: 33501952 
  58. Link-Gelles R, DellaGrotta AL, Molina C, Clyne A, Campagna K, Lanzieri TM, et al. Limited secondary transmission of SARS-CoV-2 in child care programs - Rhode Island, June 1-July 31, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(34):1170-2.  https://doi.org/10.15585/mmwr.mm6934e2  PMID: 32853185 
  59. Lopez AS, Hill M, Antezano J, Vilven D, Rutner T, Bogdanow L, et al. Transmission dynamics of COVID-19 outbreaks associated with child care facilities - Salt Lake City, Utah, April-July 2020. MMWR Morb Mortal Wkly Rep. 2020;69(37):1319-23.  https://doi.org/10.15585/mmwr.mm6937e3  PMID: 32941418 
  60. The National Collaborating Centre for Methods and Tools (McMaster University). Rapid review update 7: what is the specific role of daycares and schools in COVID-19 transmission? Hamilton: McMaster University; 2020. Available from: https://www.nccmt.ca/knowledge-repositories/covid-19-rapid-evidence-service
  61. Otte Im Kampe E, Lehfeld AS, Buda S, Buchholz U, Haas W. Surveillance of COVID-19 school outbreaks, Germany, March to August 2020. Euro Surveill. 2020;25(38):2001645.  https://doi.org/10.2807/1560-7917.ES.2020.25.38.2001645  PMID: 32975186 
  62. Ehrhardt J, Ekinci A, Krehl H, Meincke M, Finci I, Klein J, et al. Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-Württemberg, Germany. Euro Surveill. 2020;25(36):2001587.  https://doi.org/10.2807/1560-7917.ES.2020.25.36.2001587  PMID: 32914746 
  63. Buonsenso D, De Rose C, Moroni R, Valentini P. SARS-CoV-2 infections in Italian schools: preliminary findings after one month of school opening during the second wave of the pandemic. medRxiv. 2020:2020.10. . https://doi.org/10.1101/2020.10.10.20210328 
  64. Ismail SA, Saliba V, Lopez Bernal JA, Ramsay ME, Ladhani SN. SARS-CoV-2 infection and transmission in educational settings: cross-sectional analysis of clusters and outbreaks in England. medRxiv. 2020:2020.08.21.20178574. Preprint.
  65. Viner RM, Russell SJ, Croker H, Packer J, Ward J, Stansfield C, et al. School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet Child Adolesc Health. 2020;4(5):397-404.  https://doi.org/10.1016/S2352-4642(20)30095-X  PMID: 32272089 
  66. Abdollahi E, Haworth-Brockman M, Keynan Y, Langley JM, Moghadas SM. Simulating the effect of school closure during COVID-19 outbreaks in Ontario, Canada. BMC Med. 2020;18(1):230.  https://doi.org/10.1186/s12916-020-01705-8  PMID: 32709232 
  67. Iwata K, Doi A, Miyakoshi C. Was school closure effective in mitigating coronavirus disease 2019 (COVID-19)? Time series analysis using Bayesian inference. Int J Infect Dis. 2020;99:57-61.  https://doi.org/10.1016/j.ijid.2020.07.052  PMID: 32745628 
  68. Viner R, Waddington C, Mytton O, Booy R, Cruz J, Ward J, et al. Transmission of SARS-CoV-2 by children and young people in households and schools: a meta-analysis of population-based and contact-tracing studies. J Infect. 2021.22:S0163-4453(21)00633-2.
  69. Armann JP, Unrath M, Kirsten C, Lueck C, Dalpke A, Berner R. Anti-SARS-CoV-2 IgG antibodies in adolescent students and their teachers in Saxony, Germany (SchoolCoviDD19): very low seropraevalence and transmission rates. medRxiv. 2020:2020.07.16.20155143. Preprint.
  70. Fontanet A, Grant R, Tondeur L, Madec Y, Grzelak L, Cailleau I, et al. SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission. medRxiv. 2020:2020.06.25.20140178. Preprint . https://doi.org/10.1101/2020.06.25.20140178 
  71. Fontanet A, Tondeur L, Madec Y, Grant R, Besombes C, Jolly N, et al. Cluster of COVID-19 in northern France: A retrospective closed cohort study. medRxiv. 2020:2020.04.18.20071134. Preprint.
  72. Torres JP, Piñera C, De La Maza V, Lagomarcino AJ, Simian D, Torres B, et al. Severe acute respiratory syndrome coronavirus 2 antibody prevalence in blood in a large school community subject to a coronavirus disease 2019 outbreak: a cross-sectional study. Clin Infect Dis. 2021;73(2):e458-65.  https://doi.org/10.1093/cid/ciaa955  PMID: 32649743 
  73. Brown NE, Bryant-Genevier J, Bandy U, Browning CA, Berns AL, Dott M, et al. Antibody responses after classroom exposure to teacher with coronavirus disease, March 2020. Emerg Infect Dis. 2020;26(9):2263-5.  https://doi.org/10.3201/eid2609.201802  PMID: 32597750 
  74. Desmet S, Ekinci E, Wouters I, Decru B, Beuselinck K, Malhotra-Kumar S, et al. No SARS-CoV-2 carriage observed in children attending daycare centers during the intial weeks of the epidemic in Belgium. J Med Virol. 2021;93(3):1828-31.  https://doi.org/10.1002/jmv.26689  PMID: 33230857 
  75. Indenbaum V, Lustig Y, Mendelson E, Hershkovitz Y, Glatman-Freedman A, Keinan-Boker L, et al. Under-diagnosis of SARS-CoV-2 infections among children aged 0-15 years, a nationwide seroprevalence study, Israel, January 2020 to March 2021. Euro Surveill. 2021;26(48):2101040.  https://doi.org/10.2807/1560-7917.ES.2021.26.48.2101040  PMID: 34857069 
  76. Cicero A, Potter C, Kirk Sell T, Rivers C, Schoch-Spana M. Filling in the blanks: national research needs to guide decisions about reopening schools in the United States. Baltimore: Johns Hopkins Center for Health Security; 2020. Available from: https://www.centerforhealthsecurity.org/our-work/pubs_archive/pubs-pdfs/2020/200515-reopening-schools.pdf
  77. Langlois EV, Straus SE, Antony J, King VJ, Tricco AC. Using rapid reviews to strengthen health policy and systems and progress towards universal health coverage. BMJ Glob Health. 2019;4(1):e001178.  https://doi.org/10.1136/bmjgh-2018-001178  PMID: 30899562 
  78. Henry BM, de Oliveira MHS. Preliminary epidemiological analysis on children and adolescents with novel coronavirus disease 2019 outside Hubei Province, China: an observational study utilizing crowdsourced data. medRxiv. 2020:2020.03.01.20029884. Priprint . https://doi.org/10.1101/2020.03.01.20029884 
  79. Liao J, Fan S, Chen J, Wu J, Xu S, Guo Y, et al. Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults. medRxiv. 2020:2020.03. . https://doi.org/10.1101/2020.03.10.20032136 
Transmission of SARS-CoV-2 by children: a rapid review, 30 December 2019 to 10 August 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Barbara+Clyne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Clyne Barbara</a>, <a href="/search?value1=Karen+Jordan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jordan Karen</a>, <a href="/search?value1=Susan+Ahern&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ahern Susan</a>, <a href="/search?value1=Kieran+A+Walsh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Walsh Kieran A</a>, <a href="/search?value1=Paula+Byrne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Byrne Paula</a>, <a href="/search?value1=Paul+G+Carty&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carty Paul G</a>, <a href="/search?value1=Linda+Drummond&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drummond Linda</a>, <a href="/search?value1=Kirsty+K+O%E2%80%99Brien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">O’Brien Kirsty K</a>, <a href="/search?value1=Susan+M+Smith&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Smith Susan M</a>, <a href="/search?value1=Patricia+Harrington&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harrington Patricia</a>, <a href="/search?value1=M%C3%A1ir%C3%ADn+Ryan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ryan Máirín</a>, <a href="/search?value1=Michelle+O%E2%80%99Neill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">O’Neill Michelle</a></span>. Transmission of SARS-CoV-2 by children: a rapid review, 30 December 2019 to 10 August 2020. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(5):pii=2001651. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.5.2001651" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.5.2001651</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Sept 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jan 2021 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.5.2001651
/content/10.2807/1560-7917.ES.2022.27.5.2001651
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