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Abstract

Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.

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/content/10.2807/1560-7917.ES.2022.27.48.2200894
2022-12-01
2024-12-22
/content/10.2807/1560-7917.ES.2022.27.48.2200894
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References

  1. European Centre for Disease Prevention and Control (ECDC). Monkeypox situation update, as of 22 November 2022. Stockholm: ECDC. [Accessed: 29 Nov 2022]. Available from: https://www.ecdc.europa.eu/en/news-events/monkeypox-situation-update
  2. Superior Health Council (SHC). Vaccination strategy against monkeypox (revision). Report 9727. Brussels: SHC; 2022. Available from: https://www.health.belgium.be/sites/default/files/uploads/fields/fpshealth_theme_file/20220907_shc_9727_monkeypox_vaccination_reviewed_vweb.pdf
  3. De Baetselier I, Van Dijck C, Kenyon C, Coppens J, Michiels J, de Block T, et al. Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium. Nat Med. 2022;28(11):2288-92.; Epub ahead of print.  https://doi.org/10.1038/s41591-022-02004-w  PMID: 35961373 
  4. Thy M, Peiffer-Smadja N, Mailhe M, Kramer L, Ferré VM, Houhou-Fidouh N, et al. Breakthrough infections after post-exposure vaccination against Monkeypox. medRxiv2022;2022.08.03.22278233 . https://doi.org/10.1101/2022.08.03.22278233 
  5. Payne AB, Ray LC, Kugeler KJ, Fothergill A, White EB, Canning M, et al. Incidence of monkeypox among unvaccinated persons compared with persons receiving ≥1 JYNNEOS vaccine dose - 32 U.S. jurisdictions, July 31-September 3, 2022. MMWR Morb Mortal Wkly Rep. 2022;71(40):1278-82.  https://doi.org/10.15585/mmwr.mm7140e3  PMID: 36201401 
  6. Hazra A, Rusie L, Hedberg T, Schneider JA. Human monkeypox virus infection in the immediate period after receiving Modified Vaccinia Ankara Vaccine. JAMA. 2022;328(20):2064-7.; Epub ahead of print.  https://doi.org/10.1001/jama.2022.18320  PMID: 36178700 
  7. Frey SE, Winokur PL, Salata RA, El-Kamary SS, Turley CB, Walter EB Jr, et al. Safety and immunogenicity of IMVAMUNE® smallpox vaccine using different strategies for a post event scenario. Vaccine. 2013;31(29):3025-33.  https://doi.org/10.1016/j.vaccine.2013.04.050  PMID: 23664987 
  8. Pittman PR, Hahn M, Lee HS, Koca C, Samy N, Schmidt D, et al. Phase 3 efficacy trial of Modified Vaccinia Ankara as a vaccine against smallpox. N Engl J Med. 2019;381(20):1897-908.  https://doi.org/10.1056/NEJMoa1817307  PMID: 31722150 
  9. Frey SE, Wald A, Edupuganti S, Jackson LA, Stapleton JT, El Sahly H, et al. Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects. Vaccine. 2015;33(39):5225-34.  https://doi.org/10.1016/j.vaccine.2015.06.075  PMID: 26143613 
  10. Fine PE, Jezek Z, Grab B, Dixon H. The transmission potential of monkeypox virus in human populations. Int J Epidemiol. 1988;17(3):643-50.  https://doi.org/10.1093/ije/17.3.643  PMID: 2850277 
  11. Arbel R, Sagy YW, Zucker R, Arieh NG, Markovits H, Abu-Ahmad W, et al. Effectiveness of a single-dose modified vaccinia Ankara in human monkeypox: an observational study. Research Square; 2022. Preprint.  https://doi.org/10.21203/rs.3.rs-1976861/v2 
  12. Zaeck LM, Lamers MM, Verstrepen BE, Bestebroer TM, van Royen ME, Götz H, et al. Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals. Nat Med. 2022; Epub ahead of print.  https://doi.org/10.1038/s41591-022-02090-w  PMID: 36257333 
  13. Welkers M, Jonges M, Van den Ouden A. Monkeypox virus whole genome sequencing using combination of NextGenPCR and Oxford Nanopore. Protocols.io. [Accessed: 9 Nov 2022]. Available from: https://www.protocols.io/private/974ACB78F83911EC998C0A58A9FEAC02?step=5
  14. Treangen TJ, Ondov BD, Koren S, Phillippy AM. The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. Genome Biol. 2014;15(11):524.  https://doi.org/10.1186/s13059-014-0524-x  PMID: 25410596 
Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nicole+Berens-Riha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berens-Riha Nicole</a>, <a href="/search?value1=Tessa+De+Block&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Block Tessa</a>, <a href="/search?value1=Jojanneke+Rutgers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rutgers Jojanneke</a>, <a href="/search?value1=Johan+Michiels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michiels Johan</a>, <a href="/search?value1=Liesbeth+Van+Gestel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Gestel Liesbeth</a>, <a href="/search?value1=Matilde+Hens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hens Matilde</a>, <a href="/search?value1=ITM+monkeypox+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">ITM monkeypox study group</a>, <a href="/search?value1=Chris+Kenyon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kenyon Chris</a>, <a href="/search?value1=Emmanuel+Bottieau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bottieau Emmanuel</a>, <a href="/search?value1=Patrick+Soentjens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Soentjens Patrick</a>, <a href="/search?value1=Johan+van+Griensven&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Griensven Johan</a>, <a href="/search?value1=Isabel+Brosius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brosius Isabel</a>, <a href="/search?value1=Kevin+K+Ari%C3%ABn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ariën Kevin K</a>, <a href="/search?value1=Marjan+Van+Esbroeck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Esbroeck Marjan</a>, <a href="/search?value1=Antonio+Mauro+Rezende&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rezende Antonio Mauro</a>, <a href="/search?value1=Koen+Vercauteren&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vercauteren Koen</a>, <a href="/search?value1=Laurens+Liesenborghs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liesenborghs Laurens</a></span>. Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(48):pii=2200894. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.48.2200894" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.48.2200894</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Nov 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 01 Dec 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.48.2200894
/content/10.2807/1560-7917.ES.2022.27.48.2200894
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