1887
  1. Home
  2. Eurosurveillance
  3. Volume 27, Issue 15, 14/Apr/2022
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years admitted to hospital with severe hepatitis of unknown aetiology. Retrospective investigation identified eight additional cases aged 10 years and younger since 1 January 2022. Two pairs of cases have epidemiological links. Common viral hepatitis causes were excluded in those with available results. Five children were adenovirus PCR-positive. Other childhood viruses, including SARS-CoV-2, have been isolated. Investigations are ongoing, with new cases still presenting.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2022.27.15.2200318
2022-04-14
2024-12-22
/content/10.2807/1560-7917.ES.2022.27.15.2200318
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/27/15/eurosurv-27-15-2.html?itemId=/content/10.2807/1560-7917.ES.2022.27.15.2200318&mimeType=html&fmt=ahah

References

  1. Braccio S, Irwin A, Riordan A, Shingadia D, Kelly DA, Bansal S, et al. Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study. Arch Dis Child. 2017;102(7):624-8.  https://doi.org/10.1136/archdischild-2016-311916  PMID: 28377449 
  2. England K, Thorne C, Pembrey L, Tovo P-A, Newell M-L. Age- and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network. J Pediatr Gastroenterol Nutr. 2009;49(1):71-7.  https://doi.org/10.1097/MPG.0b013e31818fc63b  PMID: 19465871 
  3. Scottish Government. COVID-19 Scotland’s Strategic Framework Update 2022. Edinburgh: Scottish Government. [Accessed: 12 Apr 2022]. Available from: https://www.gov.scot/binaries/content/documents/govscot/publications/strategy-plan/2022/02/coronavirus-covid-19-scotlands-strategic-framework-update-february-2022/documents/covid-19-scotlands-strategic-framework-update-february-2022/covid-19-scotlands-strategic-framework-update-february-2022/govscot%3Adocument/covid-19-scotlands-strategic-framework-update-february-2022.pdf.
  4. Public Health Scotland. COVID-19 statistical report 6 April 2022. Edinburgh: Public Health Scotland. [Accessed: 12 Apr 2022]. Available from: https://publichealthscotland.scot/publications/covid-19-statistical-report/covid-19-statistical-report-6-april-2022/.
  5. Office for National Statistics. Coronavirus (COVID-19) Infection Survey: Scotland. London: Office for National Statistics. [Accessed: 12 Apr 2022]. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/datasets/covid19infectionsurveyscotland.
  6. Public Heath Scotland. Cases of non A to E Hepatitis. Edinburgh: Public Health Scotland; 2022. Available from: https://publichealthscotland.scot/news/2022/april/cases-of-non-a-to-e-hepatitis/.
  7. UK Health Security Agency. Increase in acute hepatitis cases of unknown aetiology in children. London: UK Health Security Agency. Available from: https://www.gov.uk/government/publications/hepatitis-increase-in-acute-cases-of-unknown-aetiology-in-children/increase-in-acute-hepatitis-cases-of-unknown-aetiology-in-children.
  8. Pardinaz-Solis R, Longuere K-S, Moore S, McMullen C, Carson G, Horby P. 20.130 ISARIC–enhancing the clinical research response to epidemics. Int J Infect Dis. 2016;53:137.  https://doi.org/10.1016/j.ijid.2016.11.338 
  9. Munoz FM, Piedra PA, Demmler GJ. Disseminated adenovirus disease in immunocompromised and immunocompetent children. Clin Infect Dis. 1998;27(5):1194-200.  https://doi.org/10.1086/514978  PMID: 9827268 
  10. Rocholl C, Gerber K, Daly J, Pavia AT, Byington CL. Adenoviral infections in children: the impact of rapid diagnosis. Pediatrics. 2004;113(1):e51-6.  https://doi.org/10.1542/peds.113.1.e51  PMID: 14702495 
  11. Kiwan P, Kamel R, Kamel R, Hamod D. Adenoviral hepatitis in an immunocompetent child: case report. J Pediatr Neonatal Care. 2017;7(3):00290. 10.15406/jpnc.2017.07.00290.
Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kimberly+Marsh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marsh Kimberly</a>, <a href="/search?value1=Rachel+Tayler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tayler Rachel</a>, <a href="/search?value1=Louisa+Pollock&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pollock Louisa</a>, <a href="/search?value1=Kirsty+Roy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roy Kirsty</a>, <a href="/search?value1=Fatim+Lakha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lakha Fatim</a>, <a href="/search?value1=Antonia+Ho&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ho Antonia</a>, <a href="/search?value1=David+Henderson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Henderson David</a>, <a href="/search?value1=Titus+Divala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Divala Titus</a>, <a href="/search?value1=Sandra+Currie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Currie Sandra</a>, <a href="/search?value1=David+Yirrell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yirrell David</a>, <a href="/search?value1=Michael+Lockhart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lockhart Michael</a>, <a href="/search?value1=Maria+K.+Rossi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rossi Maria K.</a>, <a href="/search?value1=Nick+Phin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Phin Nick</a></span>. Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(15):pii=2200318. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.15.2200318" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.15.2200318</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 12 Apr 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 14 Apr 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.15.2200318
/content/10.2807/1560-7917.ES.2022.27.15.2200318
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error