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Abstract

Adults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than > 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval: 90.5–98.1 vs 48% (41.0–57.7) but not Comirnaty/Vaxzevria (91.7%; (77.5–98.2 vs 75.0% (57.8–87.9).

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A corrected article has been published for this content:
Erratum for Euro Surveill. 2021;26(28)
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/content/10.2807/1560-7917.ES.2021.26.28.2100634
2021-07-15
2024-12-21
/content/10.2807/1560-7917.ES.2021.26.28.2100634
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Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March−June 2021, England
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Annabel+A+Powell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Powell Annabel A</a>, <a href="/search?value1=Linda+Power&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Power Linda</a>, <a href="/search?value1=Samantha+Westrop&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westrop Samantha</a>, <a href="/search?value1=Kelsey+McOwat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McOwat Kelsey</a>, <a href="/search?value1=Helen+Campbell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Campbell Helen</a>, <a href="/search?value1=Ruth+Simmons&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simmons Ruth</a>, <a href="/search?value1=Mary+E+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary E</a>, <a href="/search?value1=Kevin+Brown&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brown Kevin</a>, <a href="/search?value1=Shamez+N+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez N</a>, <a href="/search?value1=Gayatri+Amirthalingam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amirthalingam Gayatri</a></span>. Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March−June 2021, England. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(28):pii=2100634. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.28.2100634" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.28.2100634</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Jun 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Jul 2021 </span> </p>
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