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Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
- Thomas Harder1 , Judith Koch1 , Sabine Vygen-Bonnet1 , Wiebe Külper-Schiek1 , Antonia Pilic1 , Sarah Reda1 , Stefan Scholz1 , Ole Wichmann1
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Citation style for this article: Harder Thomas, Koch Judith, Vygen-Bonnet Sabine, Külper-Schiek Wiebe, Pilic Antonia, Reda Sarah, Scholz Stefan, Wichmann Ole. Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021. Euro Surveill. 2021;26(28):pii=2100563. https://doi.org/10.2807/1560-7917.ES.2021.26.28.2100563 Received: 04 Jun 2021; Accepted: 14 Jul 2021
Abstract
Evidence on COVID-19 vaccine efficacy/effectiveness (VE) in preventing asymptomatic SARS-CoV-2 infections is needed to guide public health recommendations for vaccinated people. We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80–90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.
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