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Abstract

Introduction

In contrast to countries where carbapenemase-producing Enterobacterales (CPE) are endemic, only sporadic cases were reported in Switzerland until 2013. An aggravation of the epidemiological situation in neighbouring European countries indicated the need for a surveillance study in Switzerland.

Aim

We aimed to describe CPE distributions in Switzerland and identify epidemiological factors associated with changes in incidence.

Methods

Data on all human CPE isolates from 2013 to 2018 were collected by the Swiss Centre for Antibiotic Resistance (ANRESIS) and analysed for temporal and regional trends by Generalised Poisson regression. Isolates associated with infection or colonisation were included in a primary analysis; a secondary analysis included invasive isolates only. Statistical detection of regional clusters was performed with WHONET/SaTScan.

Results

We analysed 731 CPE isolates, of which 325 (44.5%) were associated with screenings and 173 (23.7%) with infections. Yearly detection of CPE isolates increased considerably during the study period from 65 to 212. The most frequently isolated species were (54%) and (28%). The most frequent genotypes were OXA-48 (43%), KPC (21%) and NDM (14%). In contrast to the French-speaking parts of Switzerland (West, Geneva) where OXA-48 were the predominant genotypes (around 60%), KPC was the most frequently detected genotype in the Italian-speaking region (63%). WHONET/SaTScan outbreak detection analysis identified seven clusters in five regions of Switzerland.

Conclusions

In a first continuous surveillance of CPE in Switzerland, we found that the epidemiological situation aggravated nationwide and that regional patterns of CPE genotypes mirrored the situation in neighbouring European countries.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2021-04-15
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.15.1900760
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Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Alban+Ramette&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramette Alban</a>, <a href="/search?value1=Michael+Gasser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gasser Michael</a>, <a href="/search?value1=Patrice+Nordmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nordmann Patrice</a>, <a href="/search?value1=Reinhard+Zbinden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zbinden Reinhard</a>, <a href="/search?value1=Jacques+Schrenzel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schrenzel Jacques</a>, <a href="/search?value1=Damir+Perisa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Perisa Damir</a>, <a href="/search?value1=Andreas+Kronenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kronenberg Andreas</a></span>. Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(15):pii=1900760. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.15.1900760" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.15.1900760</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Dec 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Jun 2020 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.15.1900760
/content/10.2807/1560-7917.ES.2021.26.15.1900760
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