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Abstract

Background

The rapid increase of bacterial antibiotic resistance could soon render our most effective method to address infections obsolete. Factors influencing pathogen resistance prevalence in human populations remain poorly described, though temperature is known to contribute to mechanisms of spread.

Aim

To quantify the role of temperature, spatially and temporally, as a mechanistic modulator of transmission of antibiotic resistant microbes.

Methods

An ecologic analysis was performed on country-level antibiotic resistance prevalence in three common bacterial pathogens across 28 European countries, collectively representing over 4 million tested isolates. Associations of minimum temperature and other predictors with change in antibiotic resistance rates over 17 years (2000–2016) were evaluated with multivariable models. The effects of predictors on the antibiotic resistance rate change across geographies were quantified.

Results

During 2000–2016, for and , European countries with 10°C warmer ambient minimum temperatures compared to others, experienced more rapid resistance increases across all antibiotic classes. Increases ranged between 0.33%/year (95% CI: 0.2 to 0.5) and 1.2%/year (95% CI: 0.4 to 1.9), even after accounting for recognised resistance drivers including antibiotic consumption and population density. For a decreasing relationship of −0.4%/year (95% CI:  −0.7 to 0.0) was found for meticillin resistance, reflecting widespread declines in meticillin-resistant across Europe over the study period.

Conclusion

We found evidence of a long-term effect of ambient minimum temperature on antibiotic resistance rate increases in Europe. Ambient temperature might considerably influence antibiotic resistance growth rates, and explain geographic differences observed in cross-sectional studies. Rising temperatures globally may hasten resistance spread, complicating mitigation efforts.

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Author’s correction for Euro Surveill. 2020;25(45)
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2020-11-12
2024-11-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.45.1900414
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Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000 and 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sarah+F+McGough&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McGough Sarah F</a>, <a href="/search?value1=Derek+R+MacFadden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">MacFadden Derek R</a>, <a href="/search?value1=Mohammad+W+Hattab&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hattab Mohammad W</a>, <a href="/search?value1=K%C3%A5re+M%C3%B8lbak&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mølbak Kåre</a>, <a href="/search?value1=Mauricio+Santillana&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Santillana Mauricio</a></span>. Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000 and 2016. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(45):pii=1900414. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.45.1900414" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.45.1900414</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Jun 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 02 Feb 2020 </span> </p>
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