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Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 – an interval-censored survival analysis
- Sarah Omar1 , Christoph Bartz2 , Sabine Becker2 , Silke Basenach3 , Sandra Pfeifer3 , Corinna Trapp4 , Hildegard Hamm5 , Hans Christoph Schlichting6 , Magdalena Friederichs7 , Ulrich Koch8 , Christian Jestrabek9 , Ernst Hilger10 , Manfred Vogt11 , Klaus Jahn12 , Simiao Chen13,14 , Till Bärnighausen13,15,16 , Philipp Zanger11,12,13,17 , on behalf of the Palatina Public Health Study Group18
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View Affiliations Hide AffiliationsAffiliations: 1 District Public Health Authority, Montabaur, Germany 2 District Public Health Authority, Trier, Germany 3 District Public Health Authority, Neustadt, Germany 4 District Health Authority, Neuwied, Germany 5 District Public Health Authority, Bad Ems, Germany 6 District Public Health Authority, Wittlich, Germany 7 District Public Health Authority, Kirchheimbolanden, Germany 8 District Public Health Authority, Pirmasens, Germany 9 District Public Health Authority, Germersheim, Germany 10 District Public Health Authority, Cochem, Germany 11 Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany 12 Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany 13 Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany 14 Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 15 Harvard Center for Population and Development Studies, Harvard University, Cambridge, United States 16 Department of Global Health and Population, Harvard School of Public Health, Boston, United States 17 Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospitals, Heidelberg, Germany 18 The participating members of the Palatina Public Health Study Group are acknowledged at the end of the articlePhilipp Zangerphilipp.zanger uni-heidelberg.de
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Citation style for this article: Omar Sarah, Bartz Christoph, Becker Sabine, Basenach Silke, Pfeifer Sandra, Trapp Corinna, Hamm Hildegard, Schlichting Hans Christoph, Friederichs Magdalena, Koch Ulrich, Jestrabek Christian, Hilger Ernst, Vogt Manfred, Jahn Klaus, Chen Simiao, Bärnighausen Till, Zanger Philipp, on behalf of the Palatina Public Health Study Group. Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 – an interval-censored survival analysis. Euro Surveill. 2020;25(30):pii=2001292. https://doi.org/10.2807/1560-7917.ES.2020.25.30.2001292 Received: 27 Jun 2020; Accepted: 30 Jul 2020
Abstract
We analysed consecutive RT-qPCR results of 537 symptomatic coronavirus disease (COVID-19) patients in home quarantine. Respectively 2, 3, and 4 weeks after symptom onset, 50%, 25% and 10% of patients had detectable RNA from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In patients with mild COVID-19, RNA detection is likely to outlast currently known periods of infectiousness by far and fixed time periods seem more appropriate in determining the length of home isolation than laboratory-based approaches.
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