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Abstract

We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.

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/content/10.2807/1560-7917.ES.2020.25.23.2000980
2020-06-11
2024-12-21
/content/10.2807/1560-7917.ES.2020.25.23.2000980
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Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Saverio+Caini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caini Saverio</a>, <a href="/search?value1=Federica+Bellerba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bellerba Federica</a>, <a href="/search?value1=Federica+Corso&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Corso Federica</a>, <a href="/search?value1=Ang%C3%A9lica+D%C3%ADaz-Basabe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Díaz-Basabe Angélica</a>, <a href="/search?value1=Gioacchino+Natoli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Natoli Gioacchino</a>, <a href="/search?value1=John+Paget&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paget John</a>, <a href="/search?value1=Federica+Facciotti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Facciotti Federica</a>, <a href="/search?value1=Simone+Pietro+De+Angelis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Angelis Simone Pietro</a>, <a href="/search?value1=Sara+Raimondi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Raimondi Sara</a>, <a href="/search?value1=Domenico+Palli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palli Domenico</a>, <a href="/search?value1=Luca+Mazzarella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mazzarella Luca</a>, <a href="/search?value1=Pier+Giuseppe+Pelicci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pelicci Pier Giuseppe</a>, <a href="/search?value1=Paolo+Vineis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vineis Paolo</a>, <a href="/search?value1=Sara+Gandini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gandini Sara</a></span>. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(23):pii=2000980. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.23.2000980</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 22 May 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Jun 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.23.2000980
/content/10.2807/1560-7917.ES.2020.25.23.2000980
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