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Abstract

Background

Diphtheria is a potentially fatal disease caused by toxigenic strains of or

Aim

Our objective was to review the epidemiology of diphtheria in the United Kingdom (UK) and the impact of recent changes in public health management and surveillance.

Methods

Putative human toxigenic diphtheria isolates in the UK are sent for species confirmation and toxigenicity testing to the National Reference Laboratory. Clinical, epidemiological and microbiological information for toxigenic cases between 2009 and 2017 are described in this population-based prospective surveillance study.

Results

There were 33 toxigenic cases of diphtheria aged 4 to 82 years. Causative species were (n = 18) and (n = 15). Most cases were cutaneous (14/18) while more than half of cases had respiratory presentations (8/15). Two thirds (23/33) of cases were inadequately immunised. Two cases with infections died, both inadequately immunised. The major risk factor for aquisition was travel to an endemic area and for contact with a companion animal. Most confirmed or isolates (441/507; 87%) submitted for toxigenicity testing were non-toxigenic however, toxin positivity rates were higher (15/23) for than (18/469). Ten non-toxigenic toxin gene-bearing (NTTB) were also detected.

Conclusion

Diphtheria is a rare disease in the UK. In the last decade, milder cutaneous cases have become more frequent. Incomplete vaccination status was strongly associated with the risk of hospitalisation and death.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2020.25.11.1900462
2020-03-19
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.11.1900462
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The changing epidemiology of diphtheria in the United Kingdom, 2009 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Charlotte+M+Gower&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gower Charlotte M</a>, <a href="/search?value1=Antonia+Scobie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scobie Antonia</a>, <a href="/search?value1=Norman+K+Fry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fry Norman K</a>, <a href="/search?value1=David+J+Litt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Litt David J</a>, <a href="/search?value1=J+Claire+Cameron&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cameron J Claire</a>, <a href="/search?value1=Meera+A+Chand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chand Meera A</a>, <a href="/search?value1=Colin+S+Brown&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brown Colin S</a>, <a href="/search?value1=Sarah+Collins&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Collins Sarah</a>, <a href="/search?value1=Joanne+M+White&option1=author&noRedirect=true" class="nonDisambigAuthorLink">White Joanne M</a>, <a href="/search?value1=Mary+E+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary E</a>, <a href="/search?value1=Gayatri+Amirthalingam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amirthalingam Gayatri</a></span>. The changing epidemiology of diphtheria in the United Kingdom, 2009 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(11):pii=1900462. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.11.1900462" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.11.1900462</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 17 Jul 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Sept 2019 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.11.1900462
/content/10.2807/1560-7917.ES.2020.25.11.1900462
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