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Abstract

The winter 2018/19 influenza season in Hong Kong has been predominated by influenza A(H1N1)pdm09 as at January 2019. We enrolled 2,016 children in three public hospitals in Hong Kong between 2 September 2018 and 11 January 2019. Using the test-negative approach, we estimated high early season effectiveness of inactivated influenza vaccine against influenza A or B of 90% (95% confidence interval (CI): 80–95%) and 92% (95% CI: 82–96%) against influenza A(H1N1)pdm09.

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/content/10.2807/1560-7917.ES.2019.24.5.1900056
2019-01-31
2024-12-23
/content/10.2807/1560-7917.ES.2019.24.5.1900056
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References

  1. Centre for Health Protection (CHP). Flu Express. Volume 15, Number 52. Hong Kong: CHP; 2019. Available from: https://www.chp.gov.hk/files/pdf/fluexpress_week52_3_1_2019_eng.pdf.
  2. Centre for Health Protection (CHP). Flu Express. Volume 16, Number 01. Hong Kong: CHP; 2019. Available from: https://www.chp.gov.hk/files/pdf/flux_wk1_10_1_2019_eng.pdf
  3. Cowling BJ, Chan K-H, Feng S, Chan EL, Lo JY, Peiris JS, et al. The effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009-2013. Vaccine. 2014;32(41):5278-84.  https://doi.org/10.1016/j.vaccine.2014.07.084  PMID: 25092636 
  4. Feng S, Chiu SS, Chan ELY, Kwan MYW, Wong JSC, Leung C-W, et al. Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study. Lancet Respir Med. 2018;6(12):925-34.  https://doi.org/10.1016/S2213-2600(18)30419-3  PMID: 30442587 
  5. Chiu SS, Kwan MYW, Feng S, Wong JSC, Leung C-W, Chan ELY, et al. Influenza vaccine effectiveness against influenza A(H3N2) hospitalizations in children in Hong Kong in a prolonged season, 2016/2017. J Infect Dis. 2018;217(9):1365-71.  https://doi.org/10.1093/infdis/jiy027  PMID: 29346614 
  6. Jackson ML, Nelson JC. The test-negative design for estimating influenza vaccine effectiveness. Vaccine. 2013;31(17):2165-8.  https://doi.org/10.1016/j.vaccine.2013.02.053  PMID: 23499601 
  7. Sullivan SG, Feng S, Cowling BJ. Potential of the test-negative design for measuring influenza vaccine effectiveness: a systematic review. Expert Rev Vaccines. 2014;13(12):1571-91.  https://doi.org/10.1586/14760584.2014.966695  PMID: 25348015 
  8. Centers for Disease Control and Prevention (CDC). CDC's Advisory Committee on Immunization Practices (ACIP) Recommends Universal Annual Influenza Vaccination. Atlanta: CDC; 2010. Available from: https://www.cdc.gov/media/pressrel/2010/r100224.htm
  9. Sullivan SG, Tchetgen Tchetgen EJ, Cowling BJ. Theoretical Basis of the Test-Negative Study Design for Assessment of Influenza Vaccine Effectiveness. Am J Epidemiol. 2016;184(5):345-53.  https://doi.org/10.1093/aje/kww064  PMID: 27587721 
  10. Centre for Health Protection (HCP). Statistics on 2018/19 Vaccination Programmes / Schemes. Hong Kong: CHP; Last accessed on Jan 18 2019. Available from: https://www.chp.gov.hk/en/features/26734.html.
  11. Rubin R. Is It Possible to Get a Flu Shot Too Early? JAMA. 2018;320(22):2299-301.  https://doi.org/10.1001/jama.2018.18373  PMID: 30477001 
  12. Lipsitch M. Challenges of vaccine effectiveness and waning studies. Clin Infect Dis. 2018.  PMID: 30204853 
  13. Skowronski DM, Leir S, Sabaiduc S, Murti M, Dickinson JA, Olsha R, et al. Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019. Euro Surveill. 2019;24(4):1900055.  https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055 
  14. Greenland S, Mansournia MA, Altman DG. Sparse data bias: a problem hiding in plain sight. BMJ. 2016;352:i1981.  https://doi.org/10.1136/bmj.i1981  PMID: 27121591 
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