-
The re-emergence of highly pathogenic avian influenza H7N9 viruses in humans in mainland China, 2019
- Deshan Yu1,2 , Guofeng Xiang1,3 , Wenfei Zhu1,4 , Xia Lei1,5 , Baodi Li2 , Yao Meng4 , Lei Yang4 , Hongyan Jiao6 , Xiyan Li4 , Weijuan Huang4 , Hejiang Wei4 , Yanping Zhang7 , Yan Hai5 , Hui Zhang2 , Hua Yue5 , Shumei Zou4 , Xiang Zhao4 , Chao Li7 , Deng Ao6 , Ye Zhang4 , Minju Tan4 , Jia Liu4 , Xuemei Zhang6 , George F. Gao4,7 , Lei Meng2,8 , Dayan Wang4,8
-
View Affiliations Hide AffiliationsAffiliations: 1 These authors contributed equally in this study as first authors 2 Gansu Provincial Center for Disease Control and Prevention, Lanzhou China 3 Jiuquan Center for Disease Control and Prevention, Jiuquan, China 4 National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention; WHO Collaborating Center for Reference and Research on Influenza; Key Laboratory for Medical Virology, National Health Commission, Beijing, China 5 Inner Mongolia Center for Disease Control and Prevention, Hohehot, China 6 Alasan League Center for Disease Control and Prevention, Alasan, China 7 Chinese Center for Disease Control and Prevention, Beijing, China 8 These authors contributed equally as last authors in this studyDayan Wangdayanwang cnic.org.cn
-
View Citation Hide Citation
Citation style for this article: Yu Deshan, Xiang Guofeng, Zhu Wenfei, Lei Xia, Li Baodi, Meng Yao, Yang Lei, Jiao Hongyan, Li Xiyan, Huang Weijuan, Wei Hejiang, Zhang Yanping, Hai Yan, Zhang Hui, Yue Hua, Zou Shumei, Zhao Xiang, Li Chao, Ao Deng, Zhang Ye, Tan Minju, Liu Jia, Zhang Xuemei, Gao George F., Meng Lei, Wang Dayan. The re-emergence of highly pathogenic avian influenza H7N9 viruses in humans in mainland China, 2019. Euro Surveill. 2019;24(21):pii=1900273. https://doi.org/10.2807/1560-7917.ES.2019.24.21.1900273 Received: 06 May 2019; Accepted: 23 May 2019
Abstract
After no reported human cases of highly pathogenic avian influenza (HPAI) H7N9 for over a year, a case with severe disease occurred in late March 2019. Among HPAI H7N9 viral sequences, those recovered from the case and from environmental samples of a poultry slaughtering stall near their home formed a distinct clade from 2017 viral sequences. Several mutations possibly associated to antigenic drift occurred in the haemagglutinin gene, potentially warranting update of H7N9 vaccine strains.
Article metrics loading...
Full text loading...
References
-
Ke C, Mok CKP, Zhu W, Zhou H, He J, Guan W, et al. Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China. Emerg Infect Dis. 2017;23(8):1332-40. https://doi.org/10.3201/eid2308.170600 PMID: 28580899
-
Zhu W, Zhou J, Li Z, Yang L, Li X, Huang W, et al. Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017. Euro Surveill. 2017;22(19):30533. https://doi.org/10.2807/1560-7917.ES.2017.22.19.30533 PMID: 28537546
-
Zhu W, Yang L, Shu Y. Did the Highly Pathogenic Avian Influenza A(H7N9) Viruses Emerged in China Raise Increased Threat to Public Health? Vector Borne Zoonotic Dis. 2019;19(1):22-5. https://doi.org/10.1089/vbz.2018.2299 PMID: 30222520
-
Shi J, Deng G, Kong H, Gu C, Ma S, Yin X, et al. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Res. 2017;27(12):1409-21. https://doi.org/10.1038/cr.2017.129 PMID: 29151586
-
Imai M, Watanabe T, Kiso M, Nakajima N, Yamayoshi S, Iwatsuki-Horimoto K, et al. A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets. Cell Host Microbe. 2017;22(5):615-626.e8. https://doi.org/10.1016/j.chom.2017.09.008 PMID: 29056430
-
Zhu W, Dong J, Zhang Y, Yang L, Li X, Chen T, et al. A Gene Constellation in Avian Influenza A (H7N9) Viruses May Have Facilitated the Fifth Wave Outbreak in China. Cell Rep. 2018;23(3):909-17. https://doi.org/10.1016/j.celrep.2018.03.081 PMID: 29669294
-
Shu Y, McCauley J. GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill. 2017;22(13):30494. https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494 PMID: 28382917
-
Henry Dunand CJ, Leon PE, Huang M, Choi A, Chromikova V, Ho IY, et al. Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell Host Microbe. 2016;19(6):800-13. https://doi.org/10.1016/j.chom.2016.05.014 PMID: 27281570
-
Tan GS, Leon PE, Albrecht RA, Margine I, Hirsh A, Bahl J, et al. Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection. PLoS Pathog. 2016;12(4):e1005578. https://doi.org/10.1371/journal.ppat.1005578 PMID: 27081859
-
Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R. Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin. PLoS One. 2013;8(2):e49597. https://doi.org/10.1371/journal.pone.0049597 PMID: 23437033
-
Wang W, Lu B, Zhou H, Suguitan AL Jr, Cheng X, Subbarao K, et al. Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets. J Virol. 2010;84(13):6570-7. https://doi.org/10.1128/JVI.00221-10 PMID: 20427525
-
Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, et al. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science. 2013;342(6155):243-7. https://doi.org/10.1126/science.1242917 PMID: 24009358
-
Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science. 2001;293(5536):1840-2. https://doi.org/10.1126/science.1062882 PMID: 11546875
-
Nguyen HT, Fry AM, Gubareva LV. Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods. Antivir Ther. 2012;17(1 Pt B):159-73. https://doi.org/10.3851/IMP2067 PMID: 22311680
-
Lan Y, Zhang Y, Dong L, Wang D, Huang W, Xin L, et al. A comprehensive surveillance of adamantane resistance among human influenza A virus isolated from mainland China between 1956 and 2009. Antivir Ther. 2010;15(6):853-9. https://doi.org/10.3851/IMP1656 PMID: 20834097
-
Zeng X, Tian G, Shi J, Deng G, Li C, Chen H. Vaccination of poultry successfully eliminated human infection with H7N9 virus in China. Sci China Life Sci. 2018;61(12):1465-73. https://doi.org/10.1007/s11427-018-9420-1 PMID: 30414008
-
Kong W, Liu L, Wang Y, He Q, Wu S, Qin Z, et al. C-terminal elongation of NS1 of H9N2 influenza virus induces a high level of inflammatory cytokines and increases transmission. J Gen Virol. 2015;96(Pt 2):259-68. https://doi.org/10.1099/vir.0.071001-0 PMID: 25326314
Data & Media loading...