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Abstract

An aim of the ECDC point prevalence survey (PPS) in European Union/European Economic Area acute care hospitals was to acquire standardised healthcare-associated infections (HAI) data. We analysed one of the most common HAIs in the ECDC PPS, healthcare-associated pneumonia (HAP). Standardised HAI case definitions were provided and countries were advised to recruit nationally representative subsets of hospitals. We calculated 95% confidence intervals (CIs) around prevalence estimates and adjusted for clustering at hospital level. Of 231,459 patients in the survey, 2,902 (1.3%; 95% CI: 1.2–1.3) fulfilled the case definition for a HAP. HAPs were most frequent in intensive care units (8.1%; 95% CI: 7.4–8.9) and among patients intubated on the day of the survey (15%; 95% CI: 14–17; n = 737 with HAP). The most frequently reported microorganism was (17% of 1,403 isolates), followed by us (12%) and spp. (12%). Antimicrobial resistance was common among isolated microorganisms. The most frequently prescribed antimicrobial group was penicillins, including combinations with beta-lactamase inhibitors. HAPs occur regularly among intubated and non-intubated patients, with marked differences between medical specialities. HAPs remain a priority for preventive interventions, including surveillance. Our data provide a reference for future prevalence of HAPs at various settings.

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2018-08-09
2024-12-21
/content/10.2807/1560-7917.ES.2018.23.32.1700843
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References

  1. Cassini A, Plachouras D, Eckmanns T, Abu Sin M, Blank HP, Ducomble T, et al. Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study. PLoS Med. 2016;13(10):e1002150.  https://doi.org/10.1371/journal.pmed.1002150  PMID: 27755545 
  2. Arefian H, Vogel M, Kwetkat A, Hartmann M. Economic evaluation of interventions for prevention of hospital acquired infections: a systematic review. PLoS One. 2016;11(1):e0146381.  https://doi.org/10.1371/journal.pone.0146381  PMID: 26731736 
  3. Bénet T, Allaouchiche B, Argaud L, Vanhems P. Impact of surveillance of hospital-acquired infections on the incidence of ventilator-associated pneumonia in intensive care units: a quasi-experimental study. Crit Care. 2012;16(4):R161.  https://doi.org/10.1186/cc11484  PMID: 22909033 
  4. Zingg W, Huttner BD, Sax H, Pittet D. Assessing the burden of healthcare-associated infections through prevalence studies: what is the best method? Infect Control Hosp Epidemiol. 2014;35(6):674-84.  https://doi.org/10.1086/676424  PMID: 24799644 
  5. Valinteliene R, Gailiene G, Berzanskyte A. Prevalence of healthcare-associated infections in Lithuania. J Hosp Infect. 2012;80(1):25-30.  https://doi.org/10.1016/j.jhin.2011.09.006  PMID: 22071001 
  6. Reilly J, Cairns S, Fleming S, Hewitt D, Lawder R, Robertson C, et al. Results from the second Scottish national prevalence survey: the changing epidemiology of healthcare-associated infection in Scotland. J Hosp Infect. 2012;82(3):170-4.  https://doi.org/10.1016/j.jhin.2012.07.024  PMID: 23022370 
  7. Lyytikäinen O, Kanerva M, Agthe N, Möttönen T, Ruutu PFinnish Prevalence Survey Study Group. Healthcare-associated infections in Finnish acute care hospitals: a national prevalence survey, 2005. J Hosp Infect. 2008;69(3):288-94.  https://doi.org/10.1016/j.jhin.2008.03.005  PMID: 18439716 
  8. Smyth ET, McIlvenny G, Enstone JE, Emmerson AM, Humphreys H, Fitzpatrick F, et al. . Four country healthcare associated infection prevalence survey 2006: overview of the results. J Hosp Infect. 2008;69(3):230-48.  https://doi.org/10.1016/j.jhin.2008.04.020  PMID: 18550218 
  9. Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. . Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198-208.  https://doi.org/10.1056/NEJMoa1306801  PMID: 24670166 
  10. van der Kooi TI, Manniën J, Wille JC, van Benthem BH. Prevalence of nosocomial infections in The Netherlands, 2007-2008: results of the first four national studies. J Hosp Infect. 2010;75(3):168-72.  https://doi.org/10.1016/j.jhin.2009.11.020  PMID: 20381910 
  11. Segagni Lusignani L, Blacky A, Starzengruber P, Diab-Elschahawi M, Wrba T, Presterl E. A national point prevalence study on healthcare-associated infections and antimicrobial use in Austria. Wien Klin Wochenschr. 2016;128(3-4):89-94.  https://doi.org/10.1007/s00508-015-0947-8  PMID: 26817781 
  12. Litvova S, Rovny I, Hudeckova H, Melus V, Stefkovicova M. A point prevalence survey of healthcare-associated infections in the Slovak Republic - a part of the EU project. Epidemiol Mikrobiol Imunol. 2014;63(2):107-12. Czech.  PMID: 25025674 
  13. Taylor G, Gravel D, Matlow A, Embree J, LeSaux N, Johnston L, et al. . Assessing the magnitude and trends in hospital acquired infections in Canadian hospitals through sequential point prevalence surveys. Antimicrob Resist Infect Control. 2016;5(1):19.  https://doi.org/10.1186/s13756-016-0118-3  PMID: 27213039 
  14. Kofteridis DP, Papadakis JA, Bouros D, Nikolaides P, Kioumis G, Levidiotou S, et al. Nosocomial lower respiratory tract infections: prevalence and risk factors in 14 Greek hospitals. Eur J Clin Microbiol Infect Dis. 2004;23(12):888-91. PMID: 15558346 
  15. Puhto T, Ylipalosaari P, Ohtonen P, Syrjala H. Point prevalence and risk factors for healthcare-associated infections in primary healthcare wards. Infection. 2011;39(3):217-23.  https://doi.org/10.1007/s15010-011-0123-7  PMID: 21573945 
  16. Lanini S, Jarvis WR, Nicastri E, Privitera G, Gesu G, Marchetti F, et al. . Healthcare-associated infection in Italy: annual point-prevalence surveys, 2002-2004. Infect Control Hosp Epidemiol. 2009;30(7):659-65.  https://doi.org/10.1086/597596  PMID: 19496645 
  17. Cairns S, Reilly J, Booth M. Prevalence of healthcare-associated infection in Scottish intensive care units. J Hosp Infect. 2010;76(4):308-10.  https://doi.org/10.1016/j.jhin.2010.05.010  PMID: 20970880 
  18. European Centre for Disease Prevention and Control (ECDC). Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals. Stockholm: ECDC: 2013. Available from: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/healthcare-associated-infections-antimicrobial-use-PPS.pdf
  19. Zingg W, Hopkins S, Gayet-Ageron A, Holmes A, Sharland M, Suetens C, et al. . Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey. Lancet Infect Dis. 2017;17(4):381-9.  https://doi.org/10.1016/S1473-3099(16)30517-5  PMID: 28089444 
  20. Zarb P, Coignard B, Griskeviciene J, Muller A, Vankerckhoven V, Weist K, et al. . The European Centre for Disease Prevention and Control (ECDC) pilot point prevalence survey of healthcare-associated infections and antimicrobial use. Euro Surveill. 2012;17(46):20316.  https://doi.org/10.2807/ese.17.46.20316-en  PMID: 23171822 
  21. McCabe WR, Jackson GG. Gram-negative bacteremia, I. etiology and ecology. Arch Intern Med. 1962;110(6):847-55.  https://doi.org/10.1001/archinte.1962.03620240029006 
  22. European Centre for Disease Prevention and Control (ECDC). Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals – protocol version 4.3. Stockholm: ECDC: 2012.Available from: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/0512-TED-PPS-HAI-antimicrobial-use-protocol.pdf
  23. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61-111.  https://doi.org/10.1093/cid/ciw353  PMID: 27418577 
  24. Montravers P, Harpan A, Guivarch E. Current and future considerations for the treatment of hospital-acquired pneumonia. Adv Ther. 2016;33(2):151-66.  https://doi.org/10.1007/s12325-016-0293-x  PMID: 26861846 
  25. Esperatti M, Ferrer M, Theessen A, Liapikou A, Valencia M, Saucedo LM, et al. Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients. Am J Respir Crit Care Med. 2010;182(12):1533-9.  https://doi.org/10.1164/rccm.201001-0094OC  PMID: 20693381 
  26. Cassini A, Colzani E, Pini A, Mangen MJ, Plass D, McDonald SA, et al. . Impact of infectious diseases on population health using incidence-based disability-adjusted life years (DALYs): results from the Burden of Communicable Diseases in Europe study, European Union and European Economic Area countries, 2009 to 2013. Euro Surveill. 2018;23(16).  https://doi.org/10.2807/1560-7917.ES.2018.23.16.17-00454  PMID: 29692315 
  27. Hansen S, Sohr D, Geffers C, Astagneau P, Blacky A, Koller W, et al. Concordance between European and US case definitions of healthcare-associated infections. Antimicrob Resist Infect Control. 2012;1(1):28.  https://doi.org/10.1186/2047-2994-1-28  PMID: 22958646 
Healthcare-associated pneumonia in acute care hospitals in European Union/European Economic Area countries: an analysis of data from a point prevalence survey, 2011 to 2012
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jan+Walter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Walter Jan</a>, <a href="/search?value1=Sebastian+Haller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haller Sebastian</a>, <a href="/search?value1=Chantal+Quinten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quinten Chantal</a>, <a href="/search?value1=Tommi+K%C3%A4rki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kärki Tommi</a>, <a href="/search?value1=Benedikt+Zacher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zacher Benedikt</a>, <a href="/search?value1=Tim+Eckmanns&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eckmanns Tim</a>, <a href="/search?value1=Muna+Abu+Sin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abu Sin Muna</a>, <a href="/search?value1=Diamantis+Plachouras&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Plachouras Diamantis</a>, <a href="/search?value1=Pete+Kinross&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kinross Pete</a>, <a href="/search?value1=Carl+Suetens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Suetens Carl</a>, <a href="/search?value1=ECDC+PPS+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">ECDC PPS study group</a></span>. Healthcare-associated pneumonia in acute care hospitals in European Union/European Economic Area countries: an analysis of data from a point prevalence survey, 2011 to 2012. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(32):pii=1700843. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.32.1700843" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.32.1700843</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 Dec 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 02 Jul 2018 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.32.1700843
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