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Abstract

Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination.

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/content/10.2807/1560-7917.ES.2018.23.3.17-00838
2018-01-18
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.3.17-00838
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Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Bo+Albinsson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Albinsson Bo</a>, <a href="/search?value1=Sirkka+Vene&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vene Sirkka</a>, <a href="/search?value1=Lars+Rombo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rombo Lars</a>, <a href="/search?value1=Jonas+Blomberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blomberg Jonas</a>, <a href="/search?value1=%C3%85ke+Lundkvist&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lundkvist Åke</a>, <a href="/search?value1=Bengt+R%C3%B6nnberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rönnberg Bengt</a></span>. Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(3):pii=17-00838. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00838" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00838</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Dec 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Jan 2018 </span> </p>
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