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Abstract

For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medical-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.

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/content/10.2807/1560-7917.ES.2018.23.3.17-00163
2018-01-18
2024-12-03
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.3.17-00163
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Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Martin+T.+Jepsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jepsen Martin T.</a>, <a href="/search?value1=Ramona+Trebbien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trebbien Ramona</a>, <a href="/search?value1=Hanne+Dorthe+Emborg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Emborg Hanne Dorthe</a>, <a href="/search?value1=Tyra+G.+Krause&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krause Tyra G.</a>, <a href="/search?value1=Kristian+Sch%C3%B8nning&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schønning Kristian</a>, <a href="/search?value1=Marianne+Voldstedlund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Voldstedlund Marianne</a>, <a href="/search?value1=Jens+Nielsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nielsen Jens</a>, <a href="/search?value1=Thea+K.+Fischer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fischer Thea K.</a></span>. Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(3):pii=17-00163. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Mar 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Jun 2017 </span> </p>
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