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Abstract

Between November 2014 and May 2018, 118 laboratory-confirmed cases of high-level azithromycin resistant were identified in England. Cases emerged among heterosexuals in Leeds but spread across England and into sexual networks of men who have sex with men as the outbreak progressed. The few epidemiological links identified indicate substantial under-diagnosis of cases and this, along with the upturn in cases in 2017, highlights the difficulties in controlling the outbreak.

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/content/10.2807/1560-7917.ES.2018.23.23.1800287
2018-06-07
2024-11-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.23.1800287
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References

  1. Public Health England (PHE). Outbreak of high level azithromycin resistant gonorrhoea in England. Health Protection Report. England: PHE; 2016;10(15). Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/516990/hpr1516_gnrrh.pdf
  2. Public Health England (PHE). Outbreak of high level azithromycin resistant gonorrhoea in England: an update. Health Protection Report. England: PHE; 2016;10(30). Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/552058/hpr3016_hlzrg.pdf
  3. Chisholm SA, Wilson J, Alexander S, Tripodo F, Al-Shahib A, Schaefer U, et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. Sex Transm Infect. 2016;92(5):365-7.  https://doi.org/10.1136/sextrans-2015-052312  PMID: 26601852 
  4. Public Health England (PHE). Resistance Alert: High-level azithromycin resistance in Neisseria gonorrhoeae. England: PHE; 2016. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/518934/HL-Azithromycin-resistant-Neisseria-gonorrhoea_20151110.pdf
  5. Public Health England (PHE). Update on investigation of UK case of Neisseria gonorrhoeae with high-level resistance to azithromycin and resistance to ceftriaxone acquired abroad. Health Protection Report. England: PHE; 2018. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/701185/hpr1418_MDRGC.pdf
  6. Public Health England (PHE). UK case of Neisseria gonorrhoeae with high-level resistance to azithromycin and resistance to ceftriaxone acquired abroad. England: PHE; 2018. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/694655/hpr1118_MDRGC.pdf
  7. Public Health England (PHE). AMR local indicators. England: PHE; 2017. Available from: https://fingertips.phe.org.uk/profile/amr-local-indicators/data#page/0/gid/1938132908/pat/6/par/E39000030/ati/129/are/E38000010
  8. Public Health England (PHE). Surveillance of antimicrobial resistance in Neisseria gonorrhoeae: key findings from the Gonococcal Resistance to Antimicrobials Surveillance Programme. England: PHE; 2017. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/651636/GRASP_Report_2017.pdf
  9. Fifer H, Cole M, Hughes G, Padfield S, Smolarchuk C, Woodford N, et al. Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study. Lancet Infect Dis. 2018;18(5):573-81.  https://doi.org/10.1016/S1473-3099(18)30122-1  PMID: 29523496 
  10. Bignell C, Unemo M, and The, European STI Guidelines Editorial Board. 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults. Int J STD AIDS. 2013;24(2):85-92.  https://doi.org/10.1177/0956462412472837  PMID: 24400344 
  11. World Health Organization (WHO). WHO guidelines for the treatment of Neisseria gonorrhoeae. Geneva: WHO; 2016. Available from: http://apps.who.int/iris/bitstream/10665/246114/1/9789241549691-eng.pdf?ua=1
  12. Lefebvre B, Martin I, Demczuk W, Deshaies L, Michaud S, Labbé A-C, et al. Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017. Emerg Infect Dis. 2018;24(2):381-3.  https://doi.org/10.3201/eid2402.171756  PMID: 29131780 
  13. de Curraize C, Kumanski S, Micaëlo M, Fournet N, La Ruche G, Meunier F, et al. Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing. Antimicrob Agents Chemother. 2016;60(11):6962-4.  https://doi.org/10.1128/AAC.01568-16  PMID: 27600036 
  14. Ohnishi M, Saika T, Hoshina S, Iwasaku K, Nakayama S, Watanabe H, et al. Ceftriaxone-resistant Neisseria gonorrhoeae, Japan. Emerg Infect Dis. 2011;17(1):148-9.  https://doi.org/10.3201/eid1701.100397  PMID: 21192886 
  15. Fifer H, Natarajan U, Jones L, Alexander S, Hughes G, Golparian D, et al. Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea. N Engl J Med. 2016;374(25):2504-6.  https://doi.org/10.1056/NEJMc1512757  PMID: 27332921 
  16. Scharbaai-Vázquez R, González-Caraballo AL, Torres-Bauzá LJ. Ceftriaxone-resistant Neisseria gonorrhoeae, Puerto Rico. Sex Transm Infect. 2015;91(2):99.  https://doi.org/10.1136/sextrans-2014-051716  PMID: 25253760 
  17. Cámara J, Serra J, Ayats J, Bastida T, Carnicer-Pont D, Andreu A, et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother. 2012;67(8):1858-60.  https://doi.org/10.1093/jac/dks162  PMID: 22566592 
  18. Wi T, Lahra MM, Ndowa F, Bala M, Dillon JR, Ramon-Pardo P, et al. Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action. PLoS Med. 2017;14(7):e1002344.  https://doi.org/10.1371/journal.pmed.1002344  PMID: 28686231 
  19. Chisholm SA, Neal TJ, Alawattegama AB, Birley HDL, Howe RA, Ison CA. Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales. J Antimicrob Chemother. 2009;64(2):353-8.  https://doi.org/10.1093/jac/dkp188  PMID: 19468025 
  20. Papp JR, Abrams AJ, Nash E, Katz AR, Kirkcaldy RD, O’Connor NP, et al. Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA. Emerg Infect Dis. 2017;23(5):830-2.  https://doi.org/10.3201/eid2305.170088  PMID: 28418303 
  21. Unemo M, Nicholas RA. Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 2012;7(12):1401-22.  https://doi.org/10.2217/fmb.12.117  PMID: 23231489 
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